Boundless Life

Full show notes: BenGreenfieldLife.com/drtyna
I'm re-airing my conversation with Dr. Tyna Moore about GLP-1s because almost everything she said about them is still being misunderstood, and she was one of the earliest voices advocating for using these drugs at very low doses. When we recorded, the internet had largely decided GLP-1 agonists were terrible: muscle wasting, "Ozempic face," suicidality, and more. Tyna's take was very different, and much of what she discussed has held up surprisingly well. Not everything, though. The big Alzheimer's trials found that GLP-1 treatment did not significantly slow disease progression.
I was the guinea pig for this one. The week before our interview, I injected one-tenth of the standard semaglutide dose, and Dr. Moore told me on air that even that was far too much for me. She was right. It took me three days to get through one porterhouse steak.
You'll hear what dosing for appetite control rather than appetite suppression actually looks like, why a natural GLP-1 stimulator may not do much if the gut cells that release GLP-1 have stopped responding, what the thyroid cancer black box warning is actually based on, what that widely shared suicidality study really measured, and how to protect your muscle while using these drugs. Dr. Tyna Moore also shares where she sends people now that she has stopped taking new patients, and the free GLP-1 Uncovered training she created.
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Full show notes: BenGreenfieldLife.com/AGIpodcast
In this episode, you'll hear how artificial intelligence is actually being pointed at aging right now, including an algorithm picking which Chinese herbs extend a fruit fly's life, plus whether the biological age test you just paid for means anything at all.
My guest is Dr. Ben Goertzel, who popularized the term artificial general intelligence, runs a decentralized AI network, and is chief scientist at Hanson Robotics. We get into the long-lived fruit flies his team works on at Genescient, the roughly five traditional Chinese herbs an AI selected from a database and combined in ways that more than double a middle-aged fly's life, and why the AI mixes them in combinations no Chinese medicine practitioner ever would. You'll also learn why he says today's biological age tests are "a little dodgy," why large language models keep handing you the existing literature instead of generating new science, and what the extracellular matrix has to do with whether your whole body is aging well. We close on the engineered enzymes he thinks will eventually re-sculpt the genome of every tissue in your body, my own follistatin gene therapy result, and the band he plays keyboards in with a humanoid robot lead singer.
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Full show notes: BenGreenfieldLife.com/506
In this episode, you'll discover three things I've been asked about constantly: whether the melatonin heart failure headline is worth worrying about, how much sleep is actually too much or too little, and the shortest route to a higher VO2 max.
I break down what the melatonin study did and did not reveal, why a key prescription detail changes how the findings should be interpreted, and why I still use high-dose melatonin for jet lag. Then I move to VO2 max, including the Norwegian 4x4 explained the way I used to coach it, what the sprint interval research says about doing it faster, and the tools that work beyond exercise, from heat acclimation to altitude to correcting an iron deficiency. You'll also hear what a new Nature study of half a million people found about the 6.4 to 7.8 hour sleep window, and why I still sleep less than that on purpose.
Finally, fertility for men and women. On the male side, scrotal temperature, timing intercourse around ovulation, the lubricant problem nobody mentions, and the supplements with real human data behind them, from L-carnitine and CoQ10 to zinc and shilajit (use code GREENFIELD for free shipping). On the female side, ovulation tracking, acupuncture, CoQ10 before egg retrieval, and inositol. Plus how to preserve fertility if you're on testosterone replacement therapy (TRT).
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Full show notes: BenGreenfieldLife.com/gutsolution
In this episode, you'll meet Josh Dech, a former paramedic turned Crohn's and colitis consultant who argues that all three things Western medicine says about inflammatory bowel disease are wrong: it's not genetic, not classically autoimmune, and not idiopathic. We walk the research trail from a 1988 Swedish twin study through the NOD2 gene to the genome-wide studies that mapped hundreds of risk loci and still explained only a sliver of the disease, and into the numbers that worry him most, where the West has 6% of the world's population but 60% of its bowel disease. You'll also get the practical half: his sequence to help stop the active cause first, then how he suggests opening the seven drainage pathways, why he takes a full history before ordering a single test, where peptides belong, what is really coming out of people during a parasite cleanse, and why $30,000 fecal transplants keep failing. Near the end, it turns personal and a little gross, into my own dairy problem and the biomechanics of a proper bowel movement.
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Full show notes: BenGreenfieldLife.com/limitlessdaily
In this episode, you'll hear repeat guest Jim Kwik talk about cognitive offloading and where the line sits between using your phone as a second brain and letting your own memory go slack. We dig into the MIT study that scanned essay writers' brains and found the ChatGPT group remembered the least of what they wrote, what London cabbies' brains looked like before satellite navigation, why movement drives brain-derived neurotrophic factor (BDNF), and why racket sports and dance sit at the top of the longevity list. You'll also learn Jim's BUILD framework for using AI as a critic rather than an answer machine, how to write an affirmation your brain will not immediately reject, the white bear effect that makes "don't check your phone" the least useful instruction you can give yourself, why the 15 to 45 minutes of sleep inertia after you wake carries more weight than any other window in your day, and the four daily basics Jim ranks above every device in his house. We close with the 40 Hz gamma protocol I now use in the early afternoon, and the surprising effect it's had on how quickly I fall asleep at night. All of this comes straight out of Jim's new book, Limitless Daily, designed to give you one simple, actionable lesson each day for an entire year.
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