Biomed Unleashed

• Commercialization of Regenerative Medicine Research – Prof. Marianne van der Steen

  How do you commercialize regenerative medicine, and why is it so challenging? What does it take to build a successful biotech startup? And are revolutionary regenerative medicine solutions closer than we think?In this episode, our guest is Marianne van der Steen, Professor of Entrepreneurship in Healthcare and Chief Business Development Officer at the MERLN Institute for Technology-Inspired Regenerative Medicine in the Netherlands. Prof. van der Steen is a founding director of REGMED XB, a translational institute with an investment of 250 million euros, which translates groundbreaking regenerative medicine technologies into commercial products and companies.Her expertise spans across not only research in biomedical entrepreneurship, but also translation of regenerative medicine into market-ready solutions, co-founding of game-changing ventures, and bridging the gap between scientists, businesspeople, and policymakers. With over 15 years of experience in scaling regenerative medicine startups, mentoring entrepreneurs, and making transatlantic collaboration possible, she is the one shaping the future of regenerative medicine.If you want to learn more about the companies and institutes mentioned in the episode, please follow the links below:MERLN Institute for Technology-Inspired Regenerative Medicine –https://merlninstitute.comRegMed XB –https://regmedxb.comCalifornia Institure for Regenerative Medicine (CIRM) –https://www.cirm.ca.gov MIRA University of Twente –https://www.utwente.nl/en/news/2010/3/116725/mira-ambitious-plan-for-the-future Hummingbird Biomedical –https://www.hummingbirdbiomedical.com ReGen Biomedical – https://www.regenbiomedical.com Vertex Pharmaceuticals –https://www.vrtx.com/home/Mayo Clinic –https://www.mayoclinic.orgNextkidney –https://nextkidney.comTimestamps:00:00 Introduction to Biomed unleashed00:39 Guest Introduction01:32 Welcome01:45 What has inspired you to focus on valorization of scientific knowledge?03:35 Why valorization of specifically regenerative medicine projects?05:14 Why is it challenging to commercialize regenerative medicine compared to other fields?07:23 What is the idea behind the RegMed XB company that you co-founded?09:34 What are the Moonshots in RegMed XB company, and why these specific Moonshots were chosen?12:00 How do you foster international and public-private collaborations within regenerative medicine field?14:29 What stage of product development are you typically involved in?17:05 Do you teach scientists entrepreneurial skills?20:08 What advice would you give to scientists who aspire to bring their knowledge to commercial applications?22:34 How do you tackle failures, and what is a failure?27:30 Why and how transatlantic collaboration between US and the Netherlands is important in the regenerative medicine field?32:08 Looking into the future, how close are we to treating patients with engineered/artificial/lab-grown human tissues?36:47 Future of in-silico trials38:34 How can we measure success?41:06 What is the most successful project you helped to upscale?43:14 Last question!45:15 Final thoughts46:09 Meet Biomed Unleashed Team46:37 Biomed Unleashed Outro

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• Genetic Approach to Regenerative Medicine – Prof. David Schaffer

  How do you get hold of the viruses and, with their help, cure some of the deadliest diseases known to humanity? In this episode, David Schaffer, Professor of Chemical and Bioengineering, and Cell and Molecular Biology at the University of California, Berkeley, who was the first scientist to apply the directed evolution to engineer viruses for gene therapy, will share with us some of the most exciting parts of his academic journey in chemical and biomolecular engineering! What is the process of directed evolution and how did it advance the field of gene therapy? Were there any unexpected findings at David Schaffer’s Laboratory that led to groundbreaking discoveries? How did the experience in founding and leading biotech companies affect his approach to academic research? In this episode, discover the answers to these questions and get more insights into David Schaffer’s academic life! Hosts and writers: Alisa Ovsiannikova, Misha Bagirov Editors: Alisa Ovsiannikova, Misha Bagirov Promotion: Amaliya Bagdasaryan Coordinator: Alisa Ovsiannikova

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• Bioengineering meets personalized medicine – Prof. Ali Khademhosseini

  What is personalised medicine and how it revolutionizes our understanding of classic medical approaches? In this Episode, Professor Ali Khademhosseini, the CEO, and Terasaki Distinguished Professor at the Terasaki Institute in Los Angeles, USA, guides us through his scientific journey in bioengineering and personalized medicine. Prof. Ali Khademhosseini was cited more than 133.000 times and has an H-index of 190. He has been honored by more than 70 major awards at both national and international levels. What motivated Prof. Ali Khademhosseini to join Terasaki institute and reform it into a new research organisation, focusing on real-life applications of tissue engineering? How did Ali Khademhosseini’s successful transition from academia to industry unleash? How are hydrogels and organs-on-a-chip revolutionizing the field of personalized medicine? Which personalized biomedical device has the highest potential to come next to clinical application? You will find the answers to these questions and many more groundbreaking and inspiring insights on Ali Khademhosseini’s career in this episode! Hosts and writers: Alisa Ovsiannikova, Misha Bagirov Editors: Alisa Ovsiannikova, Misha Bagirov Promotion: Amaliya Bagdasaryan Coordinator: Alisa Ovsiannikova

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• Path to Innovation - Prof. Robert Langer

  In our new episode, tune in to one of the most influential figures in biomedical engineering, Professor Robert Langer! This summer, Alisa Ovsiannikova and Misha Bagirov travelled all the way from the Netherlands to the US and visited MIT to conduct an incredible interview with Professor Robert Langer! As the most cited engineer in history, with over 430,000 citations and an h-index of 326, Professor Langer's contributions to the fields of tissue engineering and drug delivery systems are unmatched. His work has created countless innovations with over 1,400 patents under Prof Langer’s name. Join us as Professor Langer shares the journey that led him from a childhood chemistry kit to a groundbreaking career in chemical and biomedical engineering. In this episode, Professor Langer opens up about the critical moments when his work began gaining acceptance, the challenges and triumphs of founding biotech companies like Moderna, and how his father’s wisdom shaped his unbeatable pursuit of innovation. We also dive into the cutting-edge research happening at Langer Lab, the largest biomedical engineering lab in the world, as well as exciting advances in drug delivery systems and tissue engineering. You can find all of that and many other exciting insights in our new episode! Hosts and writers: Alisa Ovsiannikova, Misha Bagirov Editors: Rossana Serlenga, Alisa Ovsiannikova, Misha Bagirov Promotion: Amaliya Bagdasaryan Coordinator: Alisa Ovsiannikova

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• Computational Modeling - Aurélie Carlier

  What is computational modeling and how is it used in regenerative medicine? In this episode, our guest Dr. Aurélie Carlier, a tenure track associate professor at the MERLN Institute at Maastricht University, shares insights from her academic journey and sheds light on how computational modeling contributes to more effective and optimized research in regenerative medicine.What are the various methods used to model biological processes? How do different disciplines converge within the biomedical engineering field? What essential skills and knowledge are recquired for computational modeling? What is the concept of virtual patients, and is it our potential future?Find answers to these questions and more in our new episode!Hosts and Writers: Elisey Melnikov and Alisa OvsiannikovaEditor: Rossana Serlenga

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