Proteomics in Proximity

Welcome to the Olink® Proteomics in Proximity podcast! 
 
Below are some useful resources mentioned in this episode: 
 
Reagan-Udall Foundation at FDA Gerotherapeutics in Aging Event Recording available: Affecting the Aging Trajectory:  Regulatory Constructs for Gerotherapeutic Drug, Biologic and Device Development
https://reaganudall.org/news-and-events/events/affecting-aging-trajectory-regulatory-constructs-gerotherapeutic-drug
 
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 
 
UK Biobank Pharma Proteomics Project Full Cohort Study:  Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study
https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx
Organ Ageing and Ageing Clock Publications leveraging Olink Proteomics:
Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1
Goeminne et al (2024). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6
Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7
Additional publication of interest: 
Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. Kardell O (2023). J Proteome Res. 2024 Jan 5;23(1):117-129. https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473
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Welcome to the Olink® Proteomics in Proximity podcast!
Below are some useful resources mentioned in this episode:
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date. https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies
Research articles and news
UK Biobank Pharma Proteomics Project Full Cohort Study:  Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study
https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx
Parabiosis
Conboy et al (2005) Rejuvenation of aged progenitor cells by exposure to a young systemic environment.  Nature 433: 760-764. https://www.nature.com/articles/nature03260
Villeda et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature 477, 90–94 https://doi.org/10.1038/nature10357
Organ Aging/Ageing Clock Publications leveraging Olink Proteomics
Oh, H.SH et al. (2025). Plasma proteomics links brain and immune system aging with healthspan and longevity. Nat Med 31, 2703–2711. https://doi.org/10.1038/s41591-025-03798-1
Goeminne et al (2025). Plasma protein-based organ-specific aging and mortality models unveil diseases as accelerated aging of organismal systems Cell Metabolism, 37, 205-222.e6
https://www.cell.com/cell-metabolism/fulltext/S1550-4131(24)00401-7
Argentieri, M.A et al. (2024). Proteomic aging clock predicts mortality and risk of common age-related diseases in diverse populations. Nat Med 30, 2450–2460. https://doi.org/10.1038/s41591-024-03164-7
Young blood factors infused into young mice
Villeda et al (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice.  Nature Medicine.  20:659-663. https://www.nature.com/articles/nm.3569
Single cell work with Stephen Quake
Pálovics et al (2022). Molecular hallmarks of heterochronic parabiosis at single-cell resolution. Nature 603:309-314.
https://www.nature.com/articles/s41586-022-04461-2
Andrew Yang, Gladstone Institute labeling of hundreds of endogenous plasma proteins
Yang et al (2020). Physiological blood-brain transport is impaired with age by a shift in transcytosis. Nature 583: 425-430.
https://www.nature.com/articles/s41586-020-2453-z
Eric Topol episode with Tony on Ground Truths
https://erictopol.substack.com/p/tony-wyss-coray-the-science-of-aging
Mike Snyder’s team (Stanford) and the concept of Ageotypes
Ahadi S et al. (2020). Personal aging markers and ageotypes revealed by deep longitudinal profiling. Nature Medicine. 2020;26:83–90. https://www.nature.com/articles/s41591-019-0719-5
Preprint ahead of Nature Medicine paper Tony references coming out weeks after podcast episode
Ding et al (2026; preprint). Cellular Aging Signatures in the Plasma Proteome Record Human Health and Disease. bioRxiv
https://www.biorxiv.org/content/10.64898/2026.02.10.704909v1
Vero Biosciences:  Founded with Tony where a consumer can have blood measured, which organs show accelerated aging with clinician input into potential interventions.  https://www.verobioscience.com/
Teal Rise: Founded with Tony, partnering with Olink that has collected a large database to drive model building across diseases and prediction. https://tealrise.com/
Heike A. Bischoff-Ferrari and the Do-Health Trial:
Bischoff-Ferrari et al (2025). Individual and additive effects of vitamin D, omega-3, and exercise on DNA methylation clocks of biological aging in older adults in the Do-Health trial. Nature Aging. 5: 376-385.
https://www.nature.com/articles/s43587-024-00793-y
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Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY
Host:  Cindy Lawley
Co-host: Sarantis Chlamydas
Executive Producer: Cindy Lawley
Editor:  Fredrik Hamfelt, Phosworks
Project Manager: Eva Kellerman, Phosworks
For any questions regarding information Olink Proteomics, please email us at info@olink.com or visit our website: https://www.olink.com/

Welcome to the Olink® Proteomics in Proximity podcast! 
 
Below are some useful resources mentioned in this episode: 
 
Olink tools and software
·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 
 
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 
 
World Health Organization (2003). Adherence to long-term therapies: evidence for action (PDF). 
Geneva: World Health Organisation. ISBN 978-92-4-154599-0
 
Research articles and news
·       Thermo Fisher Scientific’s Olink Platform Selected for World’s Largest Human Proteome Study
https://ir.thermofisher.com/investors/news-events/news/news-details/2025/Thermo-Fisher-Scientifics-Olink-Platform-Selected-for-Worlds-Largest-Human-Proteome-Study/default.aspx
·       Hamilton Se-Hwee Oh et al 2025. Plasma proteomics links brain and immune system aging with healthspan and longevityhttps://www.nature.com/articles/s41591-025-03798-1. Nature Medicine (2025)
·       Song, Y., Abuduaini, B., Yang, X. et al. Identification of inflammatory protein biomarkers for predicting the different subtype of adult with tuberculosis: an Olink proteomic study. Inflamm. Res. 74, 60 (2025). https://doi.org/10.1007/s00011-025-02020-9
·       Ferhan Qureshi et al 2023. Analytical validation of a multi-protein, serum-based assay for disease activity assessments in multiple sclerosis. Proteomics clinical application 2023
·       Dhindsa, R.S., Burren, O.S., Sun, B.B. et al. Rare variant associations with plasma protein levels in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06547-x
https://www.nature.com/articles/s41586-023-06547-x
·       Sun, B.B., Chiou, J., Traylor, M. et al.  Plasma proteomic associations with genetics and health in the UK Biobank. 2023 Nature, DOI: 10.1038/s41586-023-06592-6 
https://www.nature.com/articles/s41586-023-06592-6
 https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehac495/6676779
·       Eldjarn GH, et al. Large-scale plasma proteomics comparisons through genetics and disease associations. Nature. 2023 Oct;622(7982):348-358. doi: 10.1038/s41586-023-06563-x
https://www.nature.com/articles/s41586-023-06563-x#Sec44
·        Carrasco-Zanini et al 2024 Proteomic prediction of common and rare diseases. https://www.nature.com/articles/s41591-024-03142-z . NatureMedicine volume 30,  pages2489–2498 (2024)
·       Watanabe K, Wilmanski T, Diener C, et al. Multiomic signatures of body mass index identify heterogeneous health phenotypes and responses to a lifestyle intervention.https://www.nature.com/articles/s41591-023-02248-0
·       Petrera A, von Toerne C, Behlr J, et al. Multiplatform Approach for Plasma Proteomics: Complementarity of Olink Proximity Extension Assay Technology to Mass Spectrometry-Based Protein Profiling. (2020) Journal of Proteome Research, 
https://pubs.acs.org/doi/pdf/10.1021/acs.jproteome.0c00641
·       Multicenter Collaborative Study to Optimize Mass Spectrometry Workflows of Clinical Specimens. 
Kardell O, von Toerne C, Merl-Pham J, König AC, Blindert M, Barth TK, Mergner J, Ludwig C, Tüshaus J, Eckert S, Müller SA, Breimann S, Giesbertz P, Bernhardt AM, Schweizer L, Albrecht V, Teupser D, Imhof A, Kuster B, Lichtenthaler SF, Mann M, Cox J, Hauck SM. J Proteome Res. 2024 Jan 5;23(1):117-129. doi: 10.1021/acs.jproteome.3c00473. Epub 2023 Nov 28. PMID: 38015820 
https://pubs.acs.org/doi/10.1021/acs.jproteome.3c00473
·       Wei, S., Shen, R., Lu, X. et al. Integrative multi-omics investigation of sleep apnea: gut microbiome metabolomics, proteomics and phenome-wide association study. Nutr Metab (Lond) 22, 57 (2025). https://doi.org/10.1186/s12986-025-00925-0
·       Liu, L., Li, M., Qin, Y. et al. Childhood obesity and insulin resistance is correlated with gut microbiome serum protein: an integrated metagenomic and proteomic analysis. Sci Rep 15, 21436 (2025). https://doi.org/10.1038/s41598-025-07357-z
·       Zhang, Xiaotao et al.Modulating a prebiotic food source influences inflammation and immune-regulating gut microbes and metabolites: insights from the BE GONE trial. eBioMedicine, Volume 98, 104873 (2023.).  10.1016/j.ebiom.2023.104873
·      &nb...

Welcome to the Olink® Proteomics in Proximity podcast! 
 
Below are some useful resources mentioned in this episode: 
 
Olink® Reveal, accessible NGS-based proteomics for every lab: https://olink.com/products/olink-reveal

Olink tools and software
·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 
 
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 
 
 
Subscribe to the podcast on your favorite player or app:
Apple Podcasts: https://apple.co/3T0YbSm 
 
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Player FM: https://player.fm/series/series-3396598 
 
 
In case you were wondering, Proteomics in Proximity refers to the principle underlying Olink technology called the Proximity Extension Assay (PEA). More information about the assay and how it works can be found here: https://bit.ly/3Rt7YiY 
 
For any questions regarding information Olink Proteomics, please email us ...

Welcome to the Olink® Proteomics in Proximity podcast! 
  
Below are some useful resources mentioned in this episode: 
 
Olink tools and software
·       Olink® Explore 3072, the platform utilized by the UK Biobank to measure ~3000 proteins in plasma: https://olink.com/products-services/explore/
·       Olink® Explore HT, Olink’s most advanced solution for high-throughput biomarker discovery, measuring 5400+ proteins simultaneously with a streamlined workflow and industry-leading specificity: https://olink.com/products-services/exploreht/ 
 
UK Biobank Pharma Proteomics Project (UKB-PPP), one of the world’s largest scientific studies of blood protein biomarkers conducted to date, https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies 
 
Press release and news story from UK Biobank:
https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/launch-of-world-s-most-significant-protein-study-set-to-usher-in-new-understanding-for-medicine
 
https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/dataset-of-thousands-of-proteins-marks-landmark-step-for-research-into-human-health
 
https://www.ukbiobank.ac.uk/learn-more-about-uk-biobank/news/uk-biobank-launches-one-of-the-largest-scientific-studies
 
News stories:
Today Programme – Professor Rory Collins live on programme, timestamp 02:36:37   
Times – ‘Game-changing’ study of blood proteins will help fight disease 
Independent – World’s largest proteins study ‘invaluable’ for understanding disease – experts 
Daily Mail – How Alzheimer's could be diagnosed a DECADE earlier following huge study of blood proteins 
Mirror – New blood test reveals risk of developing different diseases in 'new frontier of science' 
Science – Seeking disease insights, UK Biobank launches largest study of human proteins
Technology Networks – UK Biobank Launches Largest Proteomics Study for Disease Research 
Chemical and Engineering News – Pharma firms team up to study UK proteomics data 
 
Links to referred episodes: 
 • Evan – Episode 20:
    https://share.transistor.fm/s/f795811e
    https://open.spotify.com/episode/6lv5GA8hZCgDvujlBltS9f?si=36a29e6cfa4b4fae
    https://podcasts.apple.com/us/podcast/how-proteomics-is-shaping-pharma-strategies/id1645900688?i=1000635040581
• Chris – Episode 16:
    https://share.transistor.fm/s/255ad207 
    https://open.spotify.com/episode/0oe0S6zI8cryUtgZTjGlRq?si=8a7b0323b1364b96 
    https://podcasts.apple.com/us/podcast/interview-about-the-uk-biobank-with-dr-christopher-whelan/id1645900688?i=1000622521524 
 
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Amazon Music: