Can transcriptional analysis detect efficient remyelination in multiple sclerosis?
Welcome to the 29th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author of the Brain article entitled: Distinct transcriptional changes distinguish efficient and poor remyelination in multiple sclerosis We are joined by Alida Chen for an interesting discussion into detecting transcriptional changes that may identify efficient remyelination in multiple sclerosis. Using brain bank donor tissue, the authors examine donors who show efficient remyelination compared with those who had poorly remyelinating lesions. They discuss interesting findings around the epithelial–mesenchymal transition pathway as well as the MTORC1 signalling pathway. Further, the team discusses how these findings may translate to in vivo understanding of efficient remyelination in patients with MS as well as other experimental models that may help elucidate this. Check out the full article on the Brain website as part of the June 2025 issue: https://doi.org/10.1093/brain/awae414 This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.
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Nephrology Meets Neurology: how kidney health links to neurodegeneration
Welcome to the 28th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with three authors of the Brain article entitled: The relationship between kidney health and neurodegenerative diseases Ms Melody Zuo, Dr Le Chang and Professor Sarah A Gagliano Taliun grace the Brain podcast with an insightful discussion into their recent review examining the connection between kidney disease and neurogeneration. They describe the critical microvascular connection as well as the role of uraemia and small molecules like erythropoetin. Additonally, methodological issues around survival bias, the use of mendelian randomisation and the importance of metadata in the growing age of large available datasets. Check out the full article on the Brain website and will be part of the August 2025 issue: https://doi.org/10.1093/brain/awaf113 This episode was co-hosted, edited and produced by Chaitra Sathyaprakash and Andreas Thermistocleous, edited and produced by Chaitra and Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.
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Understanding traumatic brain injury with high dimensional proteomic analysis
Welcome to the 27th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Lucia M Li of the Brain article entitled: High-dimensional proteomic analysis for pathophysiological classification of traumatic brain injury Listen to the fascinating insights into classifying traumatic brain injury (TBI) using high dimensional proteomic analysis. TBI may start with a head injury but evidence suggests that multiple different underlying pathophysiological pathways can emerge thereafter. Dr Li also describes how she envisages the future of TBI assessment and potential management. Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae305 This episode was co-hosted, edited and produced by David Michael and Adam Handel, co-produced by Xin You Tai and Antonia Johnston, original music by Ammar Al-Chalabi.
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Glymphatic homeostasis in heart failure- more in but not out?
Welcome to the 26th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with first author Dr Marios Kritsilis and senior author Associate Professor Iben Lundgaard of the Brain article entitled: Loss of glymphatic homeostasis in heart failure This academic duo from Lund University discuss their fascinating findings exploring glymphatic homeostasis in a mouse model of heart failure. Counter-intuitively, there may be more influx but not efflux associated with reduced ejection fraction. This has interesting implications on heart failure associated cognitive changes and risk of developing dementia. Check out the full article on the Brain website as part of the March 2025 issue: https://doi.org/10.1093/brain/awae411 This episode was co-hosted, edited and produced by Xin You Tai and Roberto Bellanti, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.
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Adult congenital myasthenic syndromes - discussing the diagnostic dilemma and other findings from a longitudinal cohort
Welcome to the 25th episode of The Brain Podcast - the official podcast of the journals Brain and Brain Communications. This episode features a discussion with senior author Dr Tanya Stojkovic of the Brain article entitled: Congenital myasthenic syndromes in adults: clinical features, diagnosis and long-term prognosis Dr Stojkovic discusses findings from an impressive longitudinal adult cohort of congenital myasthenia syndrome and important issues around accurate diagnosis of congenital myasthenic syndromes and use of electromyography and muscle biopsy. Check out the full article on the Brain website as part of the November 2024 issue: https://doi.org/10.1093/brain/awae124 This episode was co-hosted by David Michael and Roberto Bellanti, edited and produced by Xin You Tai, co-produced by Antonia Johnston, original music by Ammar Al-Chalabi.
A fascinating, informative and digestible podcast highlighting the rich and diverse neuroscience published in the Brain journals.
The episodes will take the format of interviews with article authors and the aim is to produce an informal and enjoyable podcast that appeals to a broad audience including clinicians, researchers, students, neuroscientists, neurologists, neurosurgeons and psychiatrists
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