Optispan is a vision for what health should be.
The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. ...
Cold Plunge & Brown Fat, Different Types of Stress, and The Power of The Mind | 85
Subscribe to our channel: https://www.youtube.com/@optispan
In this episode with our guest Dr. Thomas Seager, we delve into the transformative power of cold plunge therapy and its profound effects on resilience and longevity. We explore real-life case studies, including lessons learned from infrastructure failures like Hurricane Katrina and the Oroville Dam crisis. Discover how psychological resilience shapes our responses to stress, the importance of hormesis in health, and the role of brown fat in metabolism. We also discuss the impact of fasting, caloric restriction, and the relationship between mitochondrial health and aging.
00:00 - Introduction to Cold Plunge and Resilience
03:33 - Types of Stress & Responses
14:18 - Mitochondrial Health, Caloric Restriction & Metabolism
23:05 - Cold Therapy and Brown Fat
54:10 - Conclusions & Final Thoughts
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
More places to find us:
Twitter: https://twitter.com/optispanpodcast
Twitter: https://twitter.com/optispan
Twitter: https://twitter.com/mkaeberlein
Linkedin: https://www.linkedin.com/company/optispan
Instagram: https://www.instagram.com/optispanpodcast/
TikTok: https://www.tiktok.com/@optispan
https://www.optispan.life/
Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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1:07:49
Bryan Johnson Stopped Taking THIS & It DOESN'T Make Sense... | 84
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40:03
Doctor of Naturopathy: Microbiome & SIBO, Platelet-Rich Plasma Therapy, BPC-157, Dieting Advice | 83
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1:00:28
I Took 4 Different Biological Age Tests & Compared the Results... | 82
Subscribe to our channel: https://www.youtube.com/@optispan
Related Episode(s):Biological Age & what it REALLY means | 9 - Longevity Science #3: https://youtu.be/DcxgEwQKx8Q?si=y1iF4RviJc0n__gW
In this deep dive, Matt examines the growing trend of direct-to-consumer biological (epigenetic) age testing kits, exploring their purpose, popularity, and limitations. He outlines his experimental design to evaluate the accuracy and precision of these tests, addressing important questions about what they truly measure and how reliable they are. Matt unpacks the difference between biological and chronological age, discusses the co-marketing strategies employed by these companies, and reflects on his own results to provide a critical perspective on the value of these kits.
0:00 Introduction
2:17 Experimental Design
3:03 Key Questions
5:15 Marketing Strategies of Bio-Age Companies
6:15 Biological Age vs. Chronological Age
6:49 Measuring Biological Age
8:32 Limitations of Epigenetic Clocks
13:23 Accuracy and Precision
15:49 Data Analysis
19:22 Matt’s Biological Age Results
22:53 Key Takeaways
24:50 Sanity Checks
31:58 Conclusions
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
More places to find us:
Twitter: https://twitter.com/optispanpodcast
Twitter: https://twitter.com/optispan
Twitter: https://twitter.com/mkaeberlein
Linkedin: https://www.linkedin.com/company/optispan
Instagram: https://www.instagram.com/optispanpodcast/
TikTok: https://www.tiktok.com/@optispan
https://www.optispan.life/
Hi, I'm Matt Kaeberlein. I spent the first few decades of my career doing scientific research into the biology of aging, trying to understand the finer details of how humans age in order to facilitate translational interventions that promote healthspan and improve quality of life. Now I want to take some of that knowledge out of the lab and into the hands of people who can really use it.
On this podcast I talk about all things aging and healthspan, from supplements and nutrition to the latest discoveries in longevity research. My goal is to lift the veil on the geroscience and longevity world and help you apply what we know to your own personal health trajectory. I care about quality science and will always be honest about what I don't know. I hope you'll find these episodes helpful!
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37:49
Dr Seager: Rethinking Health for Longevity | 81
Subscribe to our channel: https://www.youtube.com/@optispan
In this episode, Matt sits down with Thomas Seager, an associate professor at Arizona State University (ASU), to explore the challenges and future directions of healthcare. Drawing from his background in environmental engineering and public health, Thomas discusses the pressing health issues affecting longevity in Americans and a potential shift from a reactive healthcare model to one that emphasizes proactive health management. Together, Matt and Thomas examine the complexities of early disease detection, the promise and limitations of AI in analyzing biomarkers, and the difficulties of separating reliable information from misinformation in today’s digital landscape. Thomas shares his personal experiences with biomarkers and resilience practices, such as cold exposure therapy, while he and Matt discuss the biases in medical research and differing approaches to health.
Thomas is an Associate Professor at ASU in the School of Sustainable Engineering and the Built Environment. His research focuses on sustainable engineering and resilience, addressing topics such as infrastructure resilience, sustainable energy systems, and environmental ethics. He is also the co-founder of Morozko Forge, a company that promotes cold immersion therapy as a means of supporting metabolic resilience.
0:00 Introduction
2:34 Environmental engineering and public health
6:29 Major health crises affecting longevity
10:30 Public’s evolving views on modern healthcare
11:45 “Repair Shop” mentality in medicine
12:59 Two key questions: Advancing proactive medicine and filtering out misinformation
16:00 Understanding biomarkers
18:35 Weighing the risks and rewards of early detection
25:10 Japan’s 1991 Cold Stimulation Study
31:10 Bias and skepticism in medical research—different perspectives
39:12 The positivist approach to hypothesis-driven work
Producers: Tara Mei, Nicholas Arapis
Video Editor: Jacob Keliikoa
DISCLAIMER: The information provided on the Optispan podcast is intended solely for general educational purposes and is not meant to be, nor should it be construed as, personalized medical advice. No doctor-patient relationship is established by your use of this channel. The information and materials presented are for informational purposes only and are not a substitute for professional medical advice, diagnosis, or treatment. We strongly advise that you consult with a licensed healthcare professional for all matters concerning your health, especially before undertaking any changes based on content provided by this channel. The hosts and guests on this channel are not liable for any direct, indirect, or other damages or adverse effects that may arise from the application of the information discussed. Medical knowledge is constantly evolving; therefore, the information provided should be verified against current medical standards and practices.
More places to find us:
Twitter: https://twitter.com/optispanpodcast
Twitter: https://twitter.com/optispan
Twitter: https://twitter.com/mkaeberlein
Linkedin: https://www.linkedin.com/company/optispan
Instagram: https://www.instagram.com/optispanpodcast/
TikTok: https://www.tiktok.com/@optispan
https://www.optispan.life/
Optispan is a vision for what health should be.
The typical person gives up 10-20 years of quality life in exchange for disability, frailty, and early death. We call this "the lost decade". Time that should be spent with loved ones doing the activities you enjoy are instead spent suffering from multiple diseases and taking a cabinet full of medications that probably do as much harm as good.
We believe that the current practice of medicine is disease care, not health care. We believe that everyone can get closer to their own optimal healthspan.