Seconds out! Round one! Ding ding! And other boxing terms. We’ve found a topic on which Tom and Stuart actually disagree. Kind of. In this episode of The Studies Show, they use the examples of “the worm wars” (does deworming kids in developing countries help them stay in school?) and a new craze for “tooth bacteria” (can colonizing your mouth with a genetically-modified bacterium stop you getting cavities?) to argue about how we should make our minds up about uncertain—but potentially promising—medical treatments.The Studies Show is brought to you by Works in Progress magazine. On the show this week we discuss one of the articles in their newest issue, on “the end of lead”—the history of countries slowly removing lead from pipes, paint, and the rest, and how much work still needs to be done. Find it, and a wealth of other fascinating free articles, at worksinprogress.co.Show notes* Tom’s Unherd article about the Worm Wars* The famous 2004 paper that sparked the wars* “Deworming Debunked”, from the BMJ* The 2014 follow-up of the original dewormed Kenyan kids* GiveWell’s re-analysis of both studies* And another more recent analysis by the same org* The third study in the same kids, from 2020* 2019 paper on “resolving the worm wars”* Scott Alexander’s article on “defying cavity”—on the Lumina bacteria* Guy who claims the Lumina bacteria made him go blind* Saloni Dattani’s useful thread on Lumina* 90% of drugs in preclinical trials don’t make it to become medicine* Tom’s frankly cruel tweet where he refers to Stuart as “Goofus”CreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe
--------
1:15:56
--------
1:15:56
Paid-only Episode 21: Psychological sex differences
This is a free preview of a paid episode. To hear more, visit www.thestudiesshowpod.comInspired by a new Nature paper on how the “maths gap” emerges between girls and boys in school, Tom and Stuart look into the evidence for psychological sex differences: in maths, in mental rotation, and, yes—in whether they like pink or blue.To listen to the full episode and read the show notes, you’ll need to become a paid subscriber at www.thestudiesshowpod.com/subscribe.
--------
10:31
--------
10:31
Episode 77: Anti-ageing, part 1
Whether it’s people giving themselves goat blood transfusions in an effort to maintain their youth, or yet another influencer telling you to buy XYZ miracle supplements, anti-ageing is big business. In the first part of what will surely become a longer Studies Show series, Tom and Stuart look at the evidence for a few supposed “breakthrough” treatments that can slow down ageing: rapamycin, metformin, winding back the epigenetic clock, and calorie restriction.The Studies Show is brought to you by Works in Progress magazine. This week we talked about their new article on “through running”—the deceptively simple idea of not having trains stop at the edge of town and instead running them right through the centre. It seems obvious if you live in London, but it wasn’t always this way. Check out the article for a detailed, nerdy discussion about how we can make trains—and therefore citites—better.Show notes* New meta-analysis on rapamycin and ageing* Website for Bryan “n = 1” Johnson and his related health claims* Our World In Data on life expectancy and about the reasons why it increased* Meta-analysis on methylation and the “biological clock” as a predictor of longevity* The STAP stem cell debacle* 2016 study using Yamanaka factors to slow down ageing in mice* 2023 study of the same idea on wild-type mice, showing a 109% increase in life expectancy* 2014 Scottish study on diabetes, metformin, and life expectancy* Critical letter noting the study’s flaws* Failed replication from Denmark in 2022* The NIH’s Interventions Testing Program* Older review of calorie restriction and ageingCreditsWe’re grateful to Andrew Steele for talking to us for this episode. The Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe
--------
1:05:46
--------
1:05:46
Episode 76: The four-day week
Would you like to do 80% of your current job but for 100% of the pay? Well, of course you would. But would it be good for the economy? It’s been suggested that companies who move to four-day working weeks have happier, less frazzled employees and no noticeable loss in productivity. Some people even claim their productivity goes up!In this episode of The Studies Show, Tom and Stuart explore the theory and the evidence on the four-day week. There are some ridiculously overblown claims here, but is there any realistic stuff left over?The Studies Show is brought to you by Works in Progress magazine. As of last week there’s a new issue of the magazine, and it’s full of the usual mix of remarkable historical, technological, and scientific topics (and sometimes all three together). Find it all completely free at worksinprogress.co.Show notes* Pedro Gomes’ book Friday is the New Saturday* The Chinese city considering giving everyone Friday afternoons off* One of a few pro-4-day-week websites* 2019 Guardian report claiming that Microsoft Japan increased productivity by 40% after implementing the 4-day-week…* …and a World Economic Forum report claiming the same thing…* …debunked by Microsoft Japan’s own press release* Henry Ford: Why I Favor Five Days’ Work With Six Days’ Pay (from 1926)* Evidence that after a certain point, extra hours become counterproductive* 2023 UK trial into the 4-day week* Four-year trial of the 4-day week in Iceland* 4-day week trial (with control group) in PortugalCreditsWe’re grateful to Prof. Pedro Gomes for talking to us for this episode. The Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe
--------
49:58
--------
49:58
Episode 75: Broken windows theory
We all hate “urban decay”—graffiti, litter, boarded-up buildings. But does urban decay cause crime? That’s the premise of the “broken windows” theory: seeing a dilapidated and poorly-maintained physical environment emboldens criminals.In this episode of The Studies Show, Tom and Stuart discuss the history of, and the evidence for, broken windows theory. The theory has inspired social psychologists, criminologists, and others to do an awful lot of studies—and as we’ll discover in this episode, it seems to have inspired scientists to commit a few crimes themselves…The Studies Show is brought to you by Works in Progress magazine. In particular, it’s brought to you by this recent article on the world’s first electric grid, which is representative of the thoughtful, data-rich, well-written articles on human progress that you’ll find everywhere on the main site and its associated Substack.Show notes* Robert Jenrick confronts fare-dodgers on the London Tube…* …and talks about “broken windows” in an interview afterwards* The original “broken windows” article from The Atlantic in 1982* Philip Zimbardo’s 1969 article, including the “Bronx vs. Palo Alto” study* Diederik Stapel’s 2011 Science article on “coping with chaos”* …and an article about him after his fraud was revealed* The famous Keizer et al. study from 2008 (also in Science)* 2014 article that’s highly critical of Keizer’s research* 2017 failed replication of Keizer et al.* Useful 2020 review article on the empirical evidence for broken windows theory* 2018 Australian panel study on informal social control and crime* Article arguing NYC had a major crime decline in the 1990s, but that it wasn’t through broken-windows policing* Data on homicides in NYC by yearCreditsThe Studies Show is produced by Julian Mayers at Yada Yada Productions. This is a public episode. If you'd like to discuss this with other subscribers or get access to bonus episodes, visit www.thestudiesshowpod.com/subscribe
Netherlands