This Week in Cardiology

Listener feedback, pulmonary embolism intervention, simple vs complex in BiV pacing, exercise in AF, and TAVR for paradoxical low-flow, low-gradient aortic stenosis are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback
LBBP ICD Lead
LEADR LBBAP Trial https://pubmed.ncbi.nlm.nih.gov/41110529/
TRIC-I-HF trial
TRIC-I-HF Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
Growth of Tricuspid Interventions in Germany https://www.jacc.org/doi/10.1016/j.jcin.2025.05.030
II Treatment of Acute Intermediate-High Risk PE – the PRAGUE-26 Trial
PRAGUE-26 Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608012
III Targeting CS leads in CRT devices – DANISH-CRT Trial
DANISH-CRT Trial 10.1016/S0140-6736(26)01597-7
IV Exercise for AF, Especially When There Is LA Disease
Physical Activity and Risk of Incident AF in Atrial Cardiomyopathy https://www.jacc.org/doi/10.1016/j.jacadv.2026.102999
V Paradoxical Low-Flow, Low-Gradient AS – REBOOT-PARADOX
REBOOT-PARADOX trial 10.1016/j.jacc.2026.08.017
ROTAS Trial https://heart.bmj.com/content/110/20/1223
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Another ESC recap, listener feedback on two trials, and a paper on GLP-1 effects on inflammation from the SELECT trial are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Correction on PROFID Trial
II Listener Feedback
III Fifth Universal Definition of MI
Fifth Universal Definition of MI https://doi.org/10.1093/eurheartj/ehag101
Foy/Mandrola Editorial on Troponin Use and Interpretation https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2777967
IV New ESC HF Guidelines
ESC Guidelines for Management of HF https://doi.org/10.1093/eurheartj/ehag100
Sanjay Kaul on X https://x.com/kaulcsmc/status/2094959683215958158?s=20
Geographic Disparities in TOPCAT https://pmc.ncbi.nlm.nih.gov/articles/PMC5065247/
V AIR STEMI Trial
AIR-STEMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2605373
CR Strategies After MI https://www.jacc.org/doi/10.1016/j.jacc.2024.04.051
PRAMI Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1305520
COMPLETE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa1907775
FULL REVASC Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2314149
VI GLP-1 News – A SELECT Trial Secondary Analysis
Semaglutide and hsCRP in Patients with CVD and Obesity https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.125.074482
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

A second ESC recap plus two breaking stories on the failure of an investigational Lp(a) reducing drug and a new FDA approval of an AI-ECG app are covered by John Mandrola, MD
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Lp(a) Disappointment
HORIZON https://clinicaltrials.gov/study/NCT04023552
Press Release https://www.novartis.com/news/media-releases/novartis-announces-lpahorizon-phase-iii-topline-results-pelacarsen-patients-elevated-lpa-and-established-cardiovascular-disease-cvd
Rationale paper https://doi.org/10.1016/j.ahj.2025.03.019
II FDA Clears AI-ECG for Acute MI Detection 
Accuracy of cath lab activation decisions for STEMI-equivalent and mimic ECGs: Physicians vs. AI (Queen of Hearts by PMcardio) 10.1016/j.ajem.2025.07.061
AI-Enabled ECG Analysis Improves Diagnostic Accuracy and Reduces False STEMI Activations: A Multicenter U.S. Registry https://www.jacc.org/doi/10.1016/j.jcin.2025.10.018
Queen of Hearts™ AI ECG App https://www.powerfulmedical.com/pmcardio-stemi/
III TARGET CTCA Trial
Targeted Use of Computed Tomographic Coronary Angiography in Acute Chest Pain https://www.nejm.org/doi/10.1056/NEJMoa2608903
IV CorCal trial
Press release https://www.escardio.org/news/press/press-releases/new-data-presented-on-the-use-of-coronary-artery-calcium-for-cardiovascular-risk-assessment/
CorCal Outcomes: A randomized trial using the pooled cohort equation or coronary artery calcium to select statin therapy in primary prevention patients. Study design and baseline characteristics https://doi.org/10.1016/j.ahj.2026.107473
V AMUNDSEN Trial
LDL Cholesterol Lowering With Evolocumab Before Percutaneous Coronary Intervention for Acute Myocardial InfarctionThe AMUNDSEN Randomized Clinical Trial https://jamanetwork.com/journals/jama/fullarticle/2853274
VI TRIC-I-HF trial
Tricuspid Repair Cuts Death, HF Hospitalization in Severe TR https://www.medscape.com/viewarticle/tricuspid-repair-cuts-death-hf-hospitalization-severe-tr-2026a1000wvk
Tricuspid-Valve Intervention in Heart Failure https://www.nejm.org/doi/full/10.1056/NEJMoa2606934
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The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
 Questions or feedback, please contact news@medscape.net

ESC recaps on the SINGLE-AF trial, CMR Guide trial, two ATTR studies, PVI-SHAM-AF, STAREE, and an observational study of ICD benefit over the past decades are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I SINGLE-AF Trial
To Anticoagulate or Not in Intermediate-Risk AF: The SINGLE-AF Trial https://www.medscape.com/viewarticle/anticoagulate-or-not-intermediate-risk-af-single-af-trial-2026a1000uko
SINGLE-AF https://www.nejm.org/doi/10.1056/NEJMoa2607978
II Scar as an ICD risk stratifier
Is Scar on CMR an Indication for ICD? CMR Guide Leaves Doubts
https://www.medscape.com/viewarticle/scar-cmr-indication-icd-cmr-guide-leaves-doubts-2026a1000ukq
CMTR GUIDE Trial https://jamanetwork.com/journals/jama/fullarticle/2853395
MADIT II Trial https://www.nejm.org/doi/full/10.1056/NEJMoa013474
III Single vs Dual Therapy in ATTR-CM
HELIOS-B Trial Sub-analysis https://www.sciencedirect.com/science/article/pii/S0735109726072086
HELIOS-B Sub-analysis Editorial https://www.sciencedirect.com/science/article/pii/S0735109726073766#bib8
HELIOS-B main trial https://www.nejm.org/doi/10.1056/NEJMoa2409134
CARDIO-TTRansform Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2608510
IV A Stunning Result of another Sham-controlled AF ablation trial
Does AF Ablation Work? That's in Question After PVI-SHAM-AF https://www.medscape.com/viewarticle/does-af-ablation-work-s-question-after-sham-pvi-af-2026a1000uli
PVI-SHAM-AF Trial 10.1016/S0140-6736(26)01558-8 External Link
SHAM-PVI Trial https://jamanetwork.com/journals/jama/fullarticle/2823283
PFA-Sham Trial https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079484
V Should Older Adults Take Statins: The STAREE trial.
STAREE Strengthens Case for Over-the-Counter Statins https://www.medscape.com/viewarticle/staree-strengthens-case-over-counter-statins-2026a1000vrw
STAREE Trial https://www.nejm.org/doi/full/10.1056/NEJMoa2607314
VII Declining ICD Benefit After MI  
Mortality Reduction with ICD for Prevention of SCD Post-MI  https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag706/8768943 
CONTEMP-ICD Trial https://clinicaltrials.gov/study/NCT06543446 
PROFID-EHRA Trial https://profid-project.eu/profid-ehra-trial/ 
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net

Listener feedback on mechanical CPR devices, PFA and stroke, the Lindy effect in adopting new technology, and an ESC preview are the topics John Mandrola, MD, discusses in this week's podcast.
This podcast is intended for healthcare professionals only.
To read a partial transcript or to comment, visit:
https://www.medscape.com/twic
I Listener Feedback on Mechanical Compression Devices for OHCA
 
Mechanical CPR Device Use and Cardiac Arrest Survival
https://www.ahajournals.org/doi/10.1161/CIRCULATIONAHA.126.079272
PARAMEDIC trial https://www.thelancet.com/article/S0140-6736(14)61886-9/fulltext
CIRC trial https://www.resuscitationjournal.com/article/S0300-9572(14)00128-2/fulltext
LINC trial https://jamanetwork.com/journals/jama/fullarticle/1774037
Cochrane Review – Mechanical vs Manual Chest Compressions for Cardiac Arrest https://pmc.ncbi.nlm.nih.gov/articles/PMC6953326/
II PFA and Stroke
Risk of Stroke and TIA With PFA vs RF Ablation https://www.ahajournals.org/doi/epub/10.1161/CIRCULATIONAHA.126.081092
AVANT GUARD Trial https://www.nejm.org/do/10.1056/NEJMdo008538/full/
EMBOL-AF Registry https://academic.oup.com/eurheartj/advance-article/doi/10.1093/eurheartj/ehag217/8566008
III A New ICD Lead
LEADR LBBAP Trial https://doi.org/10.1016/j.hrthm.2026.08.030
IV ESC Preview
Mandrola's Preview of the European Society of Cardiology 2026 https://www.medscape.com/viewarticle/mandrolas-preview-european-society-cardiology-2026-2026a1000tfi
You may also like:
The Bob Harrington Show with the Stephen and Suzanne Weiss Dean of Weill Cornell Medicine, Robert A. Harrington, MD. https://www.medscape.com/author/bob-harrington
Questions or feedback, please contact news@medscape.net