What if now is the best time in decades to start a company?In this episode, taken from Speedrun, a16z’s accelerator for early-stage founders, Marc Andreessen joins games General Partner Jonathan Lai to make the case that we’re entering a once-in-a-generation window for innovation. From the rise of AI to the cultural and policy shifts reshaping the global economy, Marc explains why the next four years present a rare opportunity for builders to seize the moment.Along the way, they discuss market timing, platform shifts, and what sets successful founders apart - including lessons from Steve Jobs, insights into AI’s impact on storytelling and games, and why being “too early” can feel just like being wrong.Timecodes0:00 Lessons from Steve Jobs on Leadership & Innovation2:27 The AI Boom: How It’s Changing Everything5:52 Market Timing: The #1 Factor in Startup Success8:13 Why the Next 4 Years Are Critical for Tech11:30 AI & The Future of Gaming, Storytelling & Virtual Worlds14:28 Why Some Startups Fail While Others Explode17:11 The Role of Founders in the AI EraResources: Find Marc on X: https://x.com/pmarcaFind Jonathan on X: https://x.com/TocelotStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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Katherine Boyle: How Tech Can Rebuild America
Why does seriousness feel radical today? a16z General Partner Katherine Boyle joins The LaBossiere Podcast to explore what it means to build for the national interest—and why that starts with purpose.Katherine, part of the American Dynamism team at a16z, shares how we got to a place where public service became uncool, how tech can help rebuild trust in government, and why suffering, friction, and responsibility are essential ingredients for growth. From the collapse of civic duty to the rise of meme-driven politics, they dig into the cultural forces shaping America—and the opportunity to reclaim a sense of mission.They also discuss why Silicon Valley is more idea than place, what journalists and investors have in common, and why being laughed at might be the clearest sign you’re on the right path.Timecodes: 0:00 - Intro4:48 The Decline in Public Service7:47 Making Government Cool Again10:07 Silicon Valley’s Aversion to National Security13:15 Positive Sum vs Zero Sum Cultures16:27 China, Authoritarianism, and Doing Hard Things19:27 What Makes America Special?23:03 Silicon Valley and the “Real Economy”26:28 Investing in Mature Markets29:08 Vanna White and The Wheel of Fortune30:27 Journalism and Loneliness32:52 - Time and Suffering38:10 - Seriousness and Purpose41:11 - Is Culture Downstream of Technology?42:48 - Propaganda and Coolness as a Strategic Asset44:40 - Florida, Texas, and Regulatory Arbitrage47:51 - DC, Silicon Valley, and Florida50:20 - What Should More People Be Thinking AboutResources: Find Katherine on X: https://x.com/KTmBoyleFind Alex on X: https://x.com/adlabossiereListen to more from The LaBossiere Podcast:YouTube: https://bit.ly/3QDLQFtApple: https://apple.co/478Be6MSpotify: https://spoti.fi/3sfiFiEStay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on X: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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52:37
Where We Are in the AI Cycle
In this episode of ‘This Week in Consumer’, a16z General Partners Anish Acharya and Erik Torenberg are joined by Steven Sinofsky - Board Partner at a16z and former President of Microsoft’s Windows division - for a deep dive on how today’s AI moment mirrors (and diverges from) past computing transitions.They explore whether we’re at the “Windows 3.1” stage of AI or still in the earliest innings, why consumer adoption is outpacing developer readiness, and how frameworks like partial autonomy, jagged intelligence, and “vibe coding” are shaping what gets built next. They also dig into where the real bottlenecks lie, not in the tech, but in how companies, products, and people work. Resources: Find Anish on X: https://x.com/illscienceFind Steven on X: https://x.com/stevesiWatch Andrej Karpathy’s talk: https://www.youtube.com/watch?v=LCEmiRjPEtQ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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30:26
Building Cluely: The Viral AI Startup that raised $15M in 10 Weeks
What if virality wasn’t a tactic — but the entire product?In this episode, a16z General Partners Erik Torenberg and Bryan Kim sit down with Roy Lee, cofounder and CEO of Cluely, one of the most talked-about consumer AI startups of 2025. Cluely didn’t raise a mega round or drop a feature suite to get traction - it broke through by turning distribution into design: launching viral short-form videos, pushing polarizing product drops, and building in public with speed and spectacle.We cover:– Why virality is Cluely’s moat– Building a brand-native AI interface– The Gen Z founder mindset– What most startups get wrong about attention– Why creators are the new product managers– Cluely’s long-term vision for ambient AICluely is a glimpse at the next generation of startups, where the line between product and performance is disappearing. Timecodes: 00:00 Introduction 01:07 Early Success02:02 Roy's Journey: From College Kid to Tech Universe04:37 The Turning Point: Harvard and Beyond06:57 Building Cluey: The Early Days08:27 The Viral Strategy: Mastering Algorithms13:56 The 50 Interns Experiment15:30 The Investment Journey: Roy and Bryan's Partnership19:20 Momentum as a Moat: The Future of AI Companies20:32 The Evolution of Product Strategy in the AI Era21:19 The Importance of Speed and Adaptability22:48 The Role of Distribution in Modern Startups24:26 Roy's Journey and Product Development25:25 The Power of User Data and Feedback26:58 Innovative Marketing and Distribution Tactics28:25 The Future of AI Integration and Translucent Overlays32:15 Controversial Marketing and Authenticity34:01 The Impact of Radical Transparency36:42 The Changing Landscape of Professionalism38:26 Concluding Thoughts and Future VisionResources: Find Roy on X: https://x.com/im_roy_leeFind Bryan on X: https://x.com/kirbyman01Learn more about Cluely: http://cluely.com/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
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38:24
Chris Dixon & Tyler Cowen on Crypto, AI, and Philosophy
In this episode, general partner Chris Dixon joins economist and author Tyler Cowen to explore the themes behind Chris’s book, Read, Write, Own: Building the Next Era of the Internet.They trace the internet’s evolution from open, decentralized beginnings to today’s consolidated platforms—and ask: how can we build something better? From stablecoins, tokenized payments, and open blockchains to AI's impact on coding, media, and politics, this wide-ranging conversation dives deep into how technologies like crypto and AI could help redistribute power online and reshape the future of ownership and innovation.The two also debate:Whether banks and legacy institutions will adopt stablecoinsThe long-term role of NFTs and digital property rightsHow AI might rewrite venture capital, education, and economic planningWhether we're heading toward a creative renaissance—or a world of AI-generated monocultureListen to similar conversations, listen to web3 with a16z: https://web3-with-a16z.simplecast.com/ Resources: Listen to Conversations with Tyler: https://conversationswithtyler.com/Find Chris on X: https://x.com/cdixonFind Tyler on X: https://x.com/tylercowenJoin a16z’s Crypto Substack:https://a16zcrypto.substack.com/ Stay Updated: Let us know what you think: https://ratethispodcast.com/a16zFind a16z on Twitter: https://twitter.com/a16zFind a16z on LinkedIn: https://www.linkedin.com/company/a16zSubscribe on your favorite podcast app: https://a16z.simplecast.com/Follow our host: https://x.com/eriktorenbergPlease note that the content here is for informational purposes only; should NOT be taken as legal, business, tax, or investment advice or be used to evaluate any investment or security; and is not directed at any investors or potential investors in any a16z fund. a16z and its affiliates may maintain investments in the companies discussed. For more details please see a16z.com/disclosures.
The a16z Podcast discusses tech and culture trends, news, and the future – especially as ‘software eats the world’. It features industry experts, business leaders, and other interesting thinkers and voices from around the world. This podcast is produced by Andreessen Horowitz (aka “a16z”), a Silicon Valley-based venture capital firm. Multiple episodes are released every week; visit a16z.com for more details and to sign up for our newsletters and other content as well!
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