The Giants Shoulder

Andrew Gallimore is a neurobiologist, pharmacologist and chemist who developed the DMTx protocol — a technology that extends the most intense psychedelic experience known to science from minutes to hours. He is the author of Alien Information Theory, Reality Switch Technologies and Death by Astonishment, and is Director of Noonautics, a nonprofit dedicated to the scientific exploration of consciousness. He currently lives and works in Tokyo.Expect to learn why your brain builds alien worlds on DMT, what thalamocortical loops and attractor states actually are, why DMT may have once been an ancient neurotransmitter, why 94% of users encounter non-human entities, what Jungian archetypes can and can't explain about DMT, where Andrew disagrees with Robin Carhart-Harris on the reality of entities, what the DMTx extended state protocol is and how it works, why DMT is the only psychedelic that doesn't produce tolerance, what happens when entities deny you access to the DMT world, what darkness retreats and breathwork have to do with endogenous DMT, and much more...Timestamps:0:00 Trailer2:11 What Is the Building Alien Worlds Thesis?4:06 What Makes DMT Unique Among Psychedelics?6:57 World Space Landscape and Consensus Reality8:11 DMT Entities — Prevalence and Types11:04 Consistency of Entity Interactions13:31 Is the DMT World Real or a Hallucination?17:34 Thalamocortical Loops and World-Model Construction20:34 Attractor States Explained24:21 Why DMT’s Stability Suggests an Evolutionary Role27:25 Parallel Lives — The DMT Sleep Cycle Hypothesis28:36 What Was the Evolutionary Purpose of the DMT World?33:35 Melatonin, Serotonin and DMT — Pharmacological Cousins35:57 Is DMT Still Doing Something Important in the Brain?36:36 Noonautics and Endogenous DMT Research38:43 Debunking DMT Breathwork Courses and Pineal Myths40:45 What Does a Stable Pattern of Brain Activity Actually Look Like?43:53 Order Within Chaos — Chris Timmermann’s DMTx Findings47:16 Robin Carhart-Harris and the Jungian Archetype Debate48:37 What Jungian Archetypes Actually Are53:36 Why Archetypes Can’t Explain Alien Entities54:32 The Directed World Model — Do Entities Control Access?56:55 DMT Lockout — When Entities Deny You Entry58:30 Can You See Entities in Brain Scans?1:00:06 Future Brain Scanning Technology1:01:24 The Speed of the Switch as Evidence1:04:40 Dimensionality and Topology of the DMT World1:06:39 DMTx — What Is the Extended State Protocol?1:09:03 Target-Controlled Intravenous Infusion Explained1:11:23 Sending Specialists Into DMT Space1:13:35 Time Perception on DMT1:16:16 Surprises from DMTx Experiments1:18:15 The Future of DMT Consciousness Research1:19:12 Andrés Gómez Emilsson and the Mathematics of DMT Space...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

Dr. Matt Hill is one of the world’s leading cannabis neuroscientists, former president of the International Cannabinoid Research Society, and a researcher with over 21,000 citations studying how the endocannabinoid system regulates the brain and body.Cannabis affects different people in completely opposite ways — calming one person while causing crippling anxiety in another — and Hill explains why the biology makes this inevitable, why both sides of the cannabis debate are getting it wrong, and why legalisation in Canada accidentally destroyed the very research that could have answered our biggest questions.Expect to learn why CB1 is the most widely distributed receptor in the brain yet almost nobody has heard of it, how endocannabinoids work backwards across the synapse unlike any other signalling system, why low-dose THC calms the amygdala but high-dose THC causes paranoia and anxiety, why women get higher than men on the same dose of cannabis due to a liver enzyme difference, why only a third of people genuinely benefit from medical cannabis while a third get nothing, how cannabis triggers schizophrenia in genetically vulnerable people without actually causing the disease, why Canadian legalisation killed cannabis clinical trials through a bureaucratic GMP-versus-GPP standoff, what the real cardiovascular risks of chronic cannabis use are, why cannabis users paradoxically have lower obesity rates, and much more…Timestamps: 00:00 Trailer02:00 Dr. Matt Hill — Cannabis Neuroscientist02:25 The Endocannabinoid System: Your Body’s Own Cannabis04:23 Every Biological Function It Controls06:30 The Most Distributed Receptor Nobody’s Heard Of07:20 Why Cannabis Science Is So Politically Toxic09:35 Both Sides Are Wrong: The Three Blind Men Problem10:23 The Frustrating Polarity of the Cannabis Debate12:37 Your Personal Experience Doesn’t Generalise16:25 Why Cannabis Feels Like a Different Drug for Different People17:52 Retrograde Signalling: How Cannabis Works Backwards20:08 Low Dose Calms, High Dose Causes Paranoia — Here’s Why22:24 Women Produce More 11-Hydroxy-THC Than Men25:52 Why Receptor Distribution Makes Cannabis Unpredictable27:11 The PET Scan Problem: Why We Can’t Map Your Receptors29:04 Why Cannabis Companies Don’t Fund Real Research31:25 How Legalisation Accidentally Killed Cannabis Science34:46 The GMP vs GPP Bureaucratic Disaster38:09 David Nutt: Drug Policy Driven by Politics Not Science43:01 Why You Can’t Standardise Cannabis Dosing Like Alcohol49:44 The Three Thirds Rule: Benefit, Side Effects, or Nothing53:05 The Best Evidence: Where Cannabis Actually Works53:36 Schizophrenia Risk — It’s a Trigger, Not a Cause55:52 Cardiovascular Risk: The Under-Discussed Real Danger57:02 Does Exercise Cancel Out Cannabis Heart Risk?58:14 The Obesity Paradox: Why Cannabis Users Are Thinner01:01:03 Chronic Pain, MS, Epilepsy and PTSD — The Medical Evidence01:03:18 Final Thoughts and a Plea for Billionaire Stoners...Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚 Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜 Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/

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Dr. Elizabeth Margulis is a professor of music cognition at Princeton University and author of Transported: The Everyday Magic of Musical Daydreams.
When strangers listen to the same unfamiliar music, they independently imagine the same vivid stories — down to specific words like "frolic" and "pirates." This may be one of the most surprising findings in modern cognitive science, and it challenges everything we assume about the privacy of our own thoughts.
Expect to learn why strangers imagine the same stories when listening to identical music, how a cross-cultural experiment between the US and rural China revealed completely different imagined worlds to the same sounds, how repeated speech spontaneously transforms into song, the surprising link between psychedelic therapy and modern music therapy, why the Mozart Effect misled state legislatures, what makes certain songs irresistibly groovy, and much more
…
Timestamps:
00:00 Intro
02:45 From Concert Pianist to Cognitive Scientist
06:27 What Does a Brain Look Like Listening to Music?
09:04 How Musical Processing Differs from Speech
10:53 The Irresistible Urge to Dance
16:18 Can Animals Keep a Beat? The Snowball Experiment
23:42 Why Repetition Changes How You Feel About Music
26:31 The Speech-to-Song Illusion
32:05 Is Music Evolutionary? The Case for Social Bonding
36:36 Psychedelics and Music: What's Really Driving the Healing?
42:28 The Mozart Effect Myth
47:42 How to Raise a Musical Prodigy
49:25 Musical Daydreams: Why Strangers Imagine the Same Stories
53:11 The China Experiment: Same Music, Different Stories
1:06:57 Psychedelic Hallucinations and Musical Archetypes
1:16:17 Can Music Teach Us About Consciousness?
...
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Tim Maudlin is a philosopher of physics at NYU and founder of the John Bell Institute for the Foundations of Physics. In 1989 he published a paper proving that consciousness cannot arise from computation — thirty-five years before the world started panicking about whether ChatGPT can think.
Expect to learn why no computer programme will ever be sufficient for consciousness, why large language models operate nothing like human brains, the critical difference between intelligence and consciousness that the AI industry keeps collapsing, why Penrose's arguments about consciousness are wrong, why quantum mechanics has nothing to do with the mind, why the mind-body problem may be the most intractable problem in all of science, and much more…
Timestamps:
00:00 Why Consciousness Is Not Computable
02:35 Maudlin's 1989 Paper: Computation and Consciousness
06:01 The Thought Experiment: Beer Cans, Windmills and Conscious Machines
08:11 Why Running a Programme Can't Be Enough for Consciousness
10:36 Counterfactuals: What the Machine Would Have Done
13:56 The Cog and Wheel Machine: Stripping It Down
16:18 The Strange Anaesthesia: Jamming the Gears
19:10 Why Computational Structure Is the Wrong Level
20:08 Is This For or Against Computationalism?
23:01 The 2026 AI Consciousness Debate
25:06 Why the Turing Test Is Trivially Defeatable
27:00 Neural Nets Are Nothing Like Brains
29:12 Why the Brain Is Far More Than Neurons
31:01 HAL 9000 and How Children Actually Learn
33:27 The Car Wash Question That Breaks ChatGPT
35:18 Defining Intelligence and Consciousness
37:53 Twin Earth: Why Definitions Don't Work the Way You Think
43:06 Locked-In Syndrome and the Lobster Problem
47:08 Computation Can't Explain Pain Either
48:01 Intelligence vs Consciousness: Why You Must Separate Them
50:45 Can Anything Be Intelligent Without Being Conscious?
53:09 Is the Turing Machine Argument About Intelligence Too?
54:04 What Does Memory Actually Mean?
57:00 Can Mathematics Capture the Structure of Qualia?01:00:02 Scott Aaronson's Demolition of Integrated Information Theory
01:03:26 Why Formalising Consciousness Is a Fetishisation of Maths
01:09:00 Why There Is No Simple State Space for Vision
01:13:22 Does Quantum Mechanics Explain Consciousness?
01:18:25 The Problem with Penrose and Hameroff's Microtubule Theory
01:21:31 How Do We Actually Make Progress on Consciousness?
01:24:45 Does the Body Matter or Is It All in the Brain?
01:27:00 The Mysterian View: Why the Mind-Body Problem May Be Unsolvable
01:29:47 Could Someone Invent a New Explanatory Framework?
01:31:13 Why Pain Hurts: The Evolutionary Story
01:33:12 What Newton Would Think of General Relativity
...
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Dr. György Buzsáki is one of the world’s most influential neuroscientists and the author of The Brain from Inside Out — a radical rethinking of how the brain generates perception, memory, and consciousness.
We’ve been asking the wrong questions about the mind. Memory isn’t storage. Perception isn’t passive. Time and space aren’t sensed — they’re constructed. And the rhythms of our own bodies may be the hidden scaffolding behind everything we think, feel, and remember.
Expect to learn why the brain doesn’t record the world but predicts it, how neural rhythms act like syntax to structure our thoughts, why time is not an input but a product of the brain’s internal cycles, how space and memory emerge from the same temporal code, why consciousness might just be a performance built from nested oscillations, what happens when brain–body rhythms fall out of sync, how we can think about memory as musical replay not archival storage, how rhythm breakdown may underlie mental disorders, and much more
…
Timestamps:
00:00 Intro
01:22 The Evolution of Neuroscience Techniques
05:13 Understanding Feedforward Inhibition
08:13 The Paradigm Shift in Brain Function
12:07 The Role of Rhythms in Prediction
14:28 Overcoming Technological Barriers in Research
16:45 Mapping the Hippocampus and Microcircuitry
25:30 The Complexity of Brain Connectivity
26:24 The Future of Connectomics
34:36 The Inside Out Brain: A New Framework
42:28 The Brain's Survival Mechanism
45:00 Local and Global Brain Interactions
48:47 Evolution of Brain Complexity
52:56 Inside-Out Thinking in Neuroscience
59:32 The Importance of Body Rhythms
01:17:42 The Interconnectedness of Mind and Body
01:26:43 Understanding Brain Dynamics in Psychiatric Disorders
01:29:04 The Future of Diagnosing Mental Health Conditions
01:32:56 The Role of Technology in Neuroscience
01:35:47 Exploring the Nature of Memory
02:06:25 Consciousness and Its Complexities
...

Email for sponsorship enquiries: [email protected] ❤️ Subscribe to our main channel - https://www.youtube.com/@thegiantsshoulder?sub_confirmation=1💚
Follow on Spotify - https://open.spotify.com/show/5m3Gta5MtIYdk59pb2GJ7M?si=Ka2rAQv7TyqiC9wvGwERpA💜
Follow on Apple Podcasts - https://podcasts.apple.com/ie/podcast/the-giants-shoulder/id1752486249
Download my FREE EBook 26 Neuroscience Books for 2026 HERE: https://thegiantsshoulder.com/