Giants Shoulder

Get Jenni Your Intelligent Research Assistant (GIANT20 for 20% off) - http://jenni.ai/?utm_source=youtube&utm_medium=inf&utm_campaign=thegiantsshoulderGet Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10Denis Noble is the physiologist who built the first computer model of the heart in 1960 — and has spent the sixty years since using it to dismantle the gene-centric view of life that dominates modern biology. He took Richard Dawkins's Selfish Gene and rewrote its most famous passage word for word in reverse — and every single experiment still fits.Expect to learn why the central dogma of molecular biology is provably wrong, how your immune system rewrites its own DNA to fight off new viruses, why the peppered moth story in every biology textbook turns out to be false, what happened when Denis told Richard Dawkins "Lamarck is back" to his face, why a cell corrects roughly 800,000 DNA replication errors before it's allowed to divide, how epigenetic inheritance can persist indefinitely if the environment stays changed, whether plants might have a form of experience, and where exactly agency ends and pure chemistry begins.Timestamps0:00:00 Trailer0:02:27 Meet The Man Who Modeled The Heart By Hand0:04:43 Why The Central Dogma Of Biology Is Wrong0:06:39 The 1866 Split Between Darwin And Wallace0:09:02 The Infinite Monkey Theorem, Tested For Real0:17:30 The Peppered Moth Myth Textbooks Still Teach0:20:19 The Nobel Laureate Textbooks Forgot To Cite0:22:53 Telling Richard Dawkins "Lamarck Is Back"0:27:43 Was Lamarck's Giraffe Neck Story Actually Right?0:29:40 How Your Body Talks To Your DNA0:38:17 A New Species Evolved In Two Generations0:44:18 So What's Actually Controversial Here?0:48:09 Cellular Agency: When Cells Act Like Organisms0:53:04 Steelmanning The Case Against Cellular Agency0:55:05 The 17th-Century Prediction That Proved Purpose Works1:04:20 Your Cells Correct 800,000 DNA Errors Per Division1:13:14 Life Lives On The Edge Of Order And Chaos1:15:27 Do Plants Have Experience?1:27:31 How Does Consciousness Fit Into Systems Biology?...... Email for sponsorship enquiries: evan@thegiantsshoulder.comGS Episodes MentionedMichael Levin — Meet the Scientist Creating New Forms of Synthetic Life! Dr Michael Levin: https://www.youtube.com/watch?v=LTBZRVKUwyMPhilip Ball — Philip Ball: "Biology Is Infinitely Weirder Than We Thought": https://www.youtube.com/watch?v=9SseGx0R0fYGuest LinksOxford Faculty Page: https://www.dpag.ox.ac.uk/team/denis-noblePersonal Website: https://www.denisnoble.comGoogle Scholar: https://scholar.google.com/citations?user=J6kLmsIAAAAJ&hl=enUnderstanding Living Systems (Book): https://www.amazon.com/Understanding-Living-Systems-Life/dp/1009277367The Third Way of Evolution: https://www.thethirdwayofevolution.com/people/view/denis-noble

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqe
Get Manta Sleep Mask: https://bit.ly/4ilzfBL and Code GIANTSMANTA10
Matthew Johnson is a psychedelic addiction scientist who spent over two decades at Johns Hopkins before becoming the senior researcher at Sheppard Pratt's Center of Excellence for Psilocybin Research. He's personally guided over 100 people through high-dose psilocybin sessions and says the "mystical experience" that shows up in the data predicts recovery even after you strip out how strong the drug felt.Expect to learn how the psilocybin experience changes as the dose climbs from one gram to a full "heroic dose," why a mystical-type experience predicts addiction recovery even after controlling for how intense the drug felt, what separates a mystical experience from personal insight and emotional catharsis as predictors of healing, why DMT users around the world keep reporting the same handful of entity archetypes, the peer-reviewed Rupert Sheldrake experiment testing whether people can sense who's about to call them before the phone rings, why he thinks rigorous telepathy research keeps getting ignored rather than debunked, why a hard-nosed behavioral pharmacologist ends up leaning toward an idealist view of reality, and much more…
Timestamps:
0:00:00 Trailer
0:02:28 Who Matt Johnson Actually Is
0:04:34 How He First Got Into Psychedelics
0:09:07 Did He Sense Addiction Benefits Early On
0:15:03 The First Mystical Experience Trial At Hopkins
0:16:42 What Counts As A High Dose Session
0:22:17 How The Trip Changes From 1 To 5 Grams
0:30:41 Why Mystical Experiences Predict Better Outcomes
0:33:34 Insight And Catharsis As Separate Predictors
0:39:49 DMT Entities And Machine Elves Explained
0:44:02 Why 20% Of DMT Users See The Same Beings
0:52:58 The Peer-Reviewed Telepathy Experiment That Shocked Him
0:59:32 Why No One Has Funded A Real Telepathy Study
1:11:04 Attention Schema Theory And The Illusion Of Self
1:16:00 Could A Single Cell Have Experience
1:17:54 Why He Leans Toward Idealism Over Materialism
...
Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about...
Email for sponsorship enquiries: evan@thegiantsshoulder.com
GS Episodes Mentioned
Michael Graziano — Challenging a Famous Neuroscientist On When Consciousness First Emerged: https://www.youtube.com/watch?v=ZnasmLpY5_8
Guest Links
Sheppard Pratt Profile: https://www.sheppardpratt.org/news-views/story/sheppard-pratt-announces-dr-matthew-w-johnson-as-senior-researcher-for-the-center-of-excellence-for-psilocybin-research-and-treatment/X: https://x.com/drug_researcherGoogle Scholar: https://scholar.google.com/citations?user=fWhYUvwAAAAJ&hl=enResearchGate: https://www.researchgate.net/profile/Matthew-Johnson-57JHU Faculty Bio: https://hub.jhu.edu/experts/profiles/matthew-johnson/

Get One Month Free of Consensus (The Best Ai Science Tool): https://get.consensus.app/we00d2cmjpqe
Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about
Marjorie Woollacott is a neuroscientist who spent three decades as a hard materialist and co-wrote the textbook used to train physiotherapists worldwide. After a meditation experience her own field said was impossible, she hid it from her colleagues for over 25 years before concluding the brain does not produce consciousness — it filters it.
Expect to learn why a career materialist neuroscientist hid her own paranormal experience for 25 years, the prospective hospital studies that corroborate what patients report while clinically dead, how a comatose man with zero brain activity accurately described a nurse hiding his dentures, what terminal lucidity is and why dying Alzheimer's patients regain full clarity minutes before death, the ongoing lab research into non-speaking autistic children who appear to communicate telepathically, why Christof Koch said the data would turn his world upside down, how Bernardo Kastrup's analytic idealism compares to Woollacott's own theory of consciousness, and much more…
Timestamps
0:00:00 Trailer
0:02:46 Where Her Story Really Begins
0:05:05 The Materialist Neuroscientist She Used To Be
0:06:15 The Meditation Retreat That Broke Her Skepticism
0:14:24 What Actually Caused Her Awakening
0:22:59 How Rigorous Is Near-Death Experience Research, Really
0:24:19 The Prospective Studies Skeptics Ignore
0:25:06 The Coma Patient Who Knew Where His Dentures Were
0:35:48 Bernardo Kastrup's Analytic Idealism Explained
0:43:19 Is Terminal Lucidity Just Wishful Interpretation?
0:46:09 The Three-Year-Old's Last Request Before Dying
0:53:07 Can Consciousness Move Physical Objects?
0:58:20 Why Jung And A Nobel Physicist Believed In Idealism
1:02:59 The Telepathy Tapes, Explained
1:19:40 The Autism Vulnerability Problem With This Research
1:21:21 The 5% Above Chance Telepathy Effect
1:35:13 Designing an Experiment Skeptics Can't Dismiss...
...
Email for sponsorship enquiries: evan@thegiantsshoulder.com
GS Episodes Mentioned
Christof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaE
Guest Links
Website: https://marjoriewoollacott.com/
University of Oregon Faculty Page: https://ion.uoregon.edu/about/person-page/459
Book – Infinite Awareness: https://www.amazon.com/Infinite-Awareness-Awakening-Scientific-Mind/dp/144225033X
Academy for the Advancement of Postmaterialist Sciences Bio: https://www.aapsglobal.com/marjorie-woollacott/
ResearchGate: https://www.researchgate.net/profile/Marjorie-Woollacott

Check out Scispace (JNGIANT20: 20% off the monthly plan or JNGIANT40: 40% off the annual plan): https://scispace.com/?via=jun1giantshoulder
Get Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulder
Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about

Rick Doblin is the founder of MAPS and the man who spent 50 years dragging the world's most demonized drug into the doctor's office. He taxed legal ecstasy dealers to fund the first MDMA toxicity studies, sued the DEA with the profits, and got a Harvard PhD in public policy to beat the system from inside — then ran the only completed Phase 3 trials in history showing that two-thirds of severe PTSD patients no longer had the diagnosis after MDMA-assisted therapy.
Expect to learn how he taxed ecstasy dealers to sue the DEA, why MDMA was a couples-therapy drug before it was a party drug, the real reason Nixon criminalized psychedelics in 1970, why 88% of severe PTSD patients responded to MDMA therapy while half dropped out of standard VA treatment, why you can't get addicted to MDMA the way you can to cocaine, why you'll do more jail time for MDMA than for the same weight of cocaine, his plan for "net zero trauma by 2070," and much more…
Timestamps
0:00:00 Trailer
0:03:03 Winning the Generational Lottery After the Holocaust
0:05:27 Dropping Out of College to Study LSD
0:08:15 The Forgotten Golden Era of Psychedelic Research
0:09:33 When the CIA Weaponized LSD for Mind Control
0:13:10 Half a Pound of Mescaline and Ten Years to Recover
0:15:09 The Day a Stranger Said "There's This Drug Called Adam"
0:15:56 MDMA Was a Therapy Drug Before It Was Ecstasy
0:18:39 Sasha Shulgin, the Man Who Invented 200 Psychedelics
0:24:12 How Dealers Tweaked Molecules to Stay Legal
0:27:21 Why Nixon Really Criminalized the Hippies
0:30:04 Going to War With the DEA — and Winning
0:33:56 Founding MAPS and $200 Million Later
0:39:09 Taxing the Ecstasy Dealers to Fund the Lawsuit
0:41:33 The First MDMA Safety Study, Run on a Beach
0:42:43 The 1992 Moment That Reopened Psychedelic Science
0:44:31 The First PTSD Study, Shut Down for Politics
0:48:08 Cannabis Is Palliative, Psychedelics Are Curative
0:50:08 The Veteran Suicide Epidemic Nobody Will Fund
0:53:33 Why MAPS Bet Everything on MDMA
0:58:35 The Effect Sizes That Should Have Changed Everything
1:01:01 Why Half of Veterans Quit Standard PTSD Therapy
1:02:13 Why the Data Alone Was Never Going to Win
1:04:54 The Absurd Reason the FDA Cited: "Euphoria"
1:06:34 Why You Can't Get Hooked on MDMA
1:07:26 More Jail for MDMA Than for Cocaine
1:08:36 Net Zero Trauma by 2070
1:10:47 MDMA for Couples, and Bringing It to the World...
... Email for sponsorship enquiries:evan@thegiantsshoulder.com
Guest Links
Rick Doblin — MAPS: https://maps.org/people/rick-doblin/
Rick Doblin on X: https://x.com/RickDoblin
MAPS: https://maps.org

Check out Scispace (Use Code JNGIANT20: 20% OFF MONTHLY): https://scispace.com/?via=jun1giantshoulder
Get Muse EEG Headband (15% off): https://choosemuse.com/giantsshoulder
Want a full breakdown of your own conscious inner experience? Join the Giant's Shoulder community: https://www.skool.com/the-giants-shoulder-6526/about
Manoj Doss is a cognitive neuroscientist and one of the only people studying what psychedelics actually do to memory — trained inside the field's most prestigious lab at Johns Hopkins, he's now its most rigorous internal sceptic. His claim is heretical: the profound sense of revelation you get on a trip may be a memory glitch — a familiarity signal firing without the detail that would normally justify it, so the trip feels like downloading the truth while your brain quietly degrades what it's actually recording.
Expect to learn why the profound insights you get on psychedelics might be a memory glitch, why the entire default mode network story "needs to go to hell", what a 250-subject mega-analysis revealed that small studies missed, why salvia melts you into the couch while DMT builds whole worlds, whether DMT entities and mantises are real contact or just a brain built to see faces, why blocking a single receptor proves psychedelics aren't "keys to reality", the flaw Doss says sinks the entropic brain and REBUS, how you'd ever tell a true revelation from a beautiful lie, and much more…
Timestamps
0:00:00 Trailer
0:02:24 The One Thing Psychedelic Science Ignores: Memory
0:05:38 Why Your Worst Beliefs Feel Like Hard Facts
0:07:38 The "Sense of Knowing" That Fools Everyone
0:09:00 How Psychedelics Rewire What You Remember
0:16:11 Why Yoga Feels Better on Psilocybin
0:20:27 "The Default Mode Network Story Needs to Go to Hell"
0:27:26 How Neuroscience Invents Stories From Noise
0:35:42 Why Psychedelic Studies Are Too Small to Trust
0:40:31 Salvia: Becoming a Sentient Piece of Corn
0:44:13 The Kappa-Opioid Door Into Another Reality
0:48:00 Why Salvia Is Heaven and Ibogaine Is Hell
0:53:03 Does the Brain Have Two Reality Generators?
0:59:24 Has 20 Years of Psychedelics Taught Us Anything?1:05:18 Are DMT Entities Real? The Mantis Problem
1:13:28 Why You See Machine Elves (But His Mum Wouldn't)
1:24:29 Tearing REBUS and the Entropic Brain Apart
1:36:21 "Do Stuff in the Scanner, Stuff Happens in the Brain"
1:44:25 The Debate Robin Was Warned Not to Do...
...
Email for sponsorship enquiries: evan@thegiantsshoulder.com

GS Episodes Mentioned
Karl Friston — Meet The Neuroscientist Who Created The Best Universal Theory Of Brain Function: https://www.youtube.com/watch?v=R-IZOFs4qmY
Robin Carhart-Harris — No. 1 Psychedelic Scientist: The Entropic Brain Hypothesis, Consciousness & DMT Entities: https://www.youtube.com/watch?v=t-GkE4YtLRk
Michael Levin — Michael Levin: Bioelectricity, Morphogenesis, Platonic Spaces & Xenobots: https://www.youtube.com/watch?v=LTBZRVKUwyM
Christof Koch — The Psychedelic Trip that Convinced Christof Koch Consciousness is Fundamental: https://www.youtube.com/watch?v=kJlV-b2bvaE
David Luke — Meet the Professor of Paranormal Consciousness - DMT Entities, Telepathy Tapes & OBE's: https://www.youtube.com/watch?v=qLKD1gt1X5o
Guest Links
Manoj Doss — Dell Medical School: https://dellmed.utexas.edu/directory/manoj-dossX (Twitter): https://x.com/manojdossGoogle Scholar: https://scholar.google.com/citations?user=KFo44R0AAAAJORCID: https://orcid.org/0000-0003-2939-2522