What's Your Problem?

Circadian rhythm isn’t just controlled by your brain. Every cell in your body runs on a 24-hour cycle, including your muscle cells.
Karyn Esser is the chair of the department of physiology and aging at the University of Florida, and she’s a leading expert on circadian rhythm in muscle cells. Karyn's problem is this: How does the circadian rhythm in muscle cells change as we age, and how does exercise help keep our system in sync?
In this episode, Karyn explains:
How every cell in your body has a clock in it
How muscle clocks prepare cells for work and schedule recovery during rest
How age affects these clocks’ ability to regulate effectively
Why exercise can improve clock function
Why jet lag and late-night eating can put your body clocks out of sync
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Throughout the next few weeks, every Monday we'll be sharing some of our favorite episodes from Jacob's other show Business History. We hope you enjoy them and if you want to hear more, subscriber to Business History on Apple, Spotify or wherever you get your podcasts.
William Shockley was an electronics genius - he even won a Nobel Prize - but he was an awful boss. Shockley was a cruel, paranoid micromanager. And this annoyed the staff of brilliant young engineers he'd assembled in a quiet town in Northern California. In fact, they quit and set up a company of their own inventing silicon chips.
Robert Noyce, Gordon Moore and the rest of "The Traitorous Eight" transformed computing, but also blazed a trail for the tech founders who would flock to Silicon Valley and change the world. Members of "The Traitorous Eight" set up Intel and AMD, while also funding businesses such as Google and Slack.
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Email us at businesshistory@pushkin.fm
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Note: Today’s show is sponsored by PayPal.
Kartik Hosanagar is a professor at the Wharton School. The problems he studies include: What will it take for people to trust AI agents to buy stuff for them? And how should businesses prepare for a world where their customers include AI agents?
In this episode, Kartik explains:
Why trust in agentic shopping will arrive category by category, not all at once
How a single old Reddit post erased a thriving brand from ChatGPT’s recommendations
Why someone needs to take on the liability risk when purchases go wrong
How treating AI as just another sales channel is the mistake the movie studios made with Netflix
How to get a language model to pay attention to your brand
Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram
Email us at problem@pushkin.fm
Follow Pushkin on Instagram, LinkedIn or X
Listen to Jacob’s other show, Business History
To listen to the show ad free, sign up for Pushkin+
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Jason Ballard is the co-founder and CEO of ICON. Jason's problem is this: Can you use 3-D printing to build houses that are cheaper, better and more interesting than the houses we build now?
In this episode, Jason explains:
Why construction methods are so slow to change
How 3D printing opens up new designs for houses
How building on the Moon shaped the way Icon builds on Earth
The challenge of scaling to printing thousands of houses
Connect with us:
Follow Jacob Goldstein on LinkedIn, X and Instagram
Email us at problem@pushkin.fm
Follow Pushkin on Instagram, LinkedIn or X
Listen to Jacob’s other show, Business History
To listen to the show ad free, sign up for Pushkin+
See omnystudio.com/listener for privacy information.

Celebrated novelists, countless students and at least one billionaire have recently been accused of using AI in their writing. The most commonly cited AI detector in these cases is called Pangram.
Max Spero is the co-founder and CEO of Pangram. His problem is this: Can you build tools that reliably detect AI-generated text and images? And a few years from now, will anybody care?
In this episode, Max explains:
Why AI prose so often sounds the same
How often Pangram makes mistakes
How detectors like Pangram compete with humanizer tools
Why the big AI companies may not be interested in detection
The shifting norms around AI-generated writing
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