Addiction Medicine Journal Club

71-80 Round-Up

Quick summaries of our last 10 articles, for busy people.

71. Buprenorphine and Dental Problems

72. Symptom-Triggered Alcohol Withdrawal Management Over
Telemedicine

73. Long-Term Opioid Use After a First Prescription

74. Quick-Start Injectable Buprenorphine

75. Contingency Management for Stimulant Use Disorder and
Mortality

76. Injectable Buprenorphine in Pregnancy

77. Epic’s Opioid Risk Score

78. Treating Alcohol Use Disorder in Patients with Severe Liver Disease

79. Direct-to-Inject Buprenorphine

80. Phenobarbital for Alcohol Withdrawal

Full citations, for those who love references:



Tuan WJ, Clebak KT, Jawadi E, Snyder J, Zgierska AE. Risk of Oral Health Problems in Adults With Opioid Use Disorder Treated With
Transmucosal Buprenorphine. J Addict Med. 2025
Sep-Oct 01;19(5):529-535. doi: 10.1097/ADM.0000000000001453. Epub 2025 Mar 10. PMID: 40062592.



Sloan ME, Ngoy A, Xiao KB, Barker B, Buckley L, Fodor M, Hardy K, Hendershot CS, Kahan M, La Fleur S, Le Foll B, Manicone M, Sanches M, Simpkin E, Quilty LC, Wyman J, Tang VM, Bozinoff N. Symptom-Triggered
Alcohol Withdrawal Management Delivered Over Telemedicine.
J Addict Med. 2025 Nov-Dec 01;19(6):708-715. doi: 10.1097/ADM.0000000000001491.
Epub 2025 May 1. PMID: 40310714; PMCID: PMC12352377.



Smith AM, Shah A, Martin BC. An updated view
on the influence of initial opioid prescription characteristics on long-term
opioid use among opioid naïve patients. Drug Alcohol Depend. 2024
Dec 1;265:112463. doi: 10.1016/j.drugalcdep.2024.112463. Epub 2024 Oct 24. PMID: 39549364; PMCID: PMC11924105.



Shiwach R, Le Foll B, Alho H, Dunn KE, Strafford S, Zhao Y, Dobbins RL. Rapid vs Standard Induction to Injectable Extended-Release Buprenorphine: A Randomized Clinical Trial. JAMA Netw Open. 2025 Oct 1;8(10):e2537319. doi: 10.1001/jamanetworkopen.2025.37319. PMID: 41085986; PMCID: PMC12522003.



Coughlin LN, Tomlinson DC, Zhang L, Kim HM, Frost MC, Khazanov G, McKay JR, DePhilippis D, Lin LA. Contingency Management for Stimulant Use Disorder and Association With Mortality: A Cohort Study. Am J Psychiatry. 2025 Nov 1;182(11):1016-1023. doi: 10.1176/appi.ajp.20250053. Epub 2025 Sep 10. PMID: 40926572.

Winhusen TJ, Lofwall MR, Kropp F, Lewis D, Smid MC, Young JL, Hodgkins C, Krans EE, Hansen Z, Wachman EM, Schiff DM, Guille C, Rudolf V, Chowdhury T, Leeman L, Lewis M, Matthews AG, Cochran G, King J, Wilder C, Rosa C. Extended-Release vs Sublingual Buprenorphine in Pregnancy Through 12 Months Post Partum: A Randomized Clinical Trial. JAMA
Intern Med. 2026 May 1;186(5):533-543. doi: 10.1001/jamainternmed.2026.0057.



Hooker SA, Rossom RC, Haapala J, Crain AL, Miley K, Olson AW, Kane S, Christensen K, O'Connor PJ, Bart G, Wright EA. External
Validation of Epic's Risk of Opioid Abuse and Overdose Model Among Primary Care Patients in Three Health Systems. J Gen Intern Med. 2026 Feb 17. doi: 10.1007/s11606-026-10257-1. Epub ahead of print. PMID: 41703383.



Sundaresh R, Singh J, Meza J, Saab S, Shetty A. Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease. JAMA Netw Open. 2026 Feb 2;9(2):e2559016. doi: 10.1001/jamanetworkopen.2025.59016. PMID: 41670995; PMCID: PMC12895287.



Rosenwohl-Mack S, Heeney M, Samuel L, Anderson E, Herring AA, Sirey LR, Peterson D, Bazazi AR, Snyder H, Suen LW. Outpatient initiation of direct-to-inject buprenorphine. Drug Alcohol Depend. 2026 Jan 1;278:113011. doi: 10.1016/j.drugalcdep.2025.113011. Epub 2025 Dec 19. PMID: 41442975; PMCID: PMC13271074.



Wolpaw BJ, Oren H, Quinnan-Hostein L, Bradley KA, Johnson NJ, Hallgren KA, Gupta A, Kim HN, Granich MA, Steel TL. Hospital-Wide Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal. JAMA Netw Open. 2025 Aug 1;8(8):e2528694. doi: 10.1001/jamanetworkopen.2025.28694. PMID: 40853658; PMCID: PMC12379078.

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This episode does not offer CME, but others do. You can
get category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. Go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

---

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.



The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

Email: addictionmedicinejournalclub@gmail.com

Facebook: @AddictionMedJC

Facebook Group: Addiction Medicine Journal Club

Instagram: @AddictionMedJC

Threads: @AddictionMedJC

YouTube: addictionmedicinejournalclub

Twitter/X: @AddictionMedJC

---

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.
Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 81 we discuss using mirtazapine to treat methamphetamine
use disorder.

McKetin R, Shoptaw S, Saunders L, et al. Mirtazapine for Methamphetamine Use Disorder: A Randomized Clinical Trial. JAMA Psychiatry. 2026;83(6):581–589. doi:10.1001/jamapsychiatry.2026.0159

We also discuss behavioral treatments added to buprenorphine,
and how the FDA is promoting flavored nicotine products.



JAMA Network Open: Adjunctive Psychosocial Interventions and Opioid Abstinence Among Patients Receiving Buprenorphine



NBC News: Some ZYN nicotine pouches can be sold as safer than cigarettes, FDA says

---

This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode
and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

---

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.



The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

Email: addictionmedicinejournalclub@gmail.com

Facebook: @AddictionMedJC

Facebook Group: Addiction Medicine Journal Club

Instagram: @AddictionMedJC

Threads: @AddictionMedJC

YouTube: addictionmedicinejournalclub

Twitter/X: @AddictionMedJC

---

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 80 we discuss phenobarbital for alcohol withdrawal in the hospital.

Wolpaw BJ, Oren H, Quinnan-Hostein L, Et al. Hospital-Wide
Implementation, Clinical Outcomes, and Safety of Phenobarbital for Alcohol Withdrawal. JAMA Netw Open. 2025 Aug 1;8(8):e2528694.

We also discuss DEA scheduling of 7-OH (from kratom) and the Trump administration’s pro-alcohol policies.



The Hill: DEA moves to ban opioid-like kratom compound 7-OH



Stat News: Even with MAHA, Trump administration has gone soft on alcohol

---

This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode
and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

---

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.



The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

Email: addictionmedicinejournalclub@gmail.com

Facebook: @AddictionMedJC

Facebook Group: Addiction Medicine Journal Club

Instagram: @AddictionMedJC

Threads: @AddictionMedJC

YouTube: addictionmedicinejournalclub

Twitter/X: @AddictionMedJC

---

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 79 we discuss an article about starting long-acting injectable buprenorphine without a sublingual test dose.

Rosenwohl-Mack S, Heeney M, Samuel L, Anderson E, Herring AA, Sirey LR, Peterson D, Bazazi AR, Snyder H, Suen LW. “Outpatient initiation of direct-to-inject buprenorphine.” Drug and alcohol dependence vol. 278 (2026): 113011. doi:10.1016/j.drugalcdep.2025.113011

We also discuss keeping up with addiction medicine news from the current administration, and an articlre commendation from one of our listeners.



KFF: The independent source for health policy research, polling, and news.

KFF: View the Latest: Substance Use

KFF: Tracking Key Mental Health and Substance Use Policy Actions Under the Trump Administration

CBS News: New White House drug abuse strategy floats wastewater testing, AI, more treatment and faith-based options
Psychological Medicine: Risk factors for the development of opioid use disorder after first opioid prescription: a Swedish national study
---

This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

---

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.



The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

Email: addictionmedicinejournalclub@gmail.com

Facebook: @AddictionMedJC

Facebook Group: Addiction Medicine Journal Club

Instagram: @AddictionMedJC

Threads: @AddictionMedJC

YouTube: addictionmedicinejournalclub

Twitter/X: @AddictionMedJC

---

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices

In episode 78 we discuss treating alcohol use disorder in patients with severe liver disease.



Sundaresh R, Singh J, Meza J, Saab S, Shetty A. Medications for Alcohol Use Disorder Among Patients With Severe Alcohol-Related Liver Disease. JAMA Netw Open. 2026;9(2):e2559016. doi:10.1001/jamanetworkopen.2025.59016



We also discuss the final dissolution of Perdue Pharma.

The Guardian: Purdue Pharma to be dissolved as judge approves criminal sentence in opioid case

---

This podcast offers category 1 and MATE-ACT CME credits through MI CARES and Michigan State University. To get credit for this episode and others, go to this link to make your account, take a brief quiz, and claim your credit. To learn more about opportunities in addiction medicine, visit MI CARES.

CME: https://micaresed.org/courses/podcast-addiction-medicine-journal-club/

---

Original theme music: composed and performed by Benjamin Kennedy

Audio editing: Michael Bonanno

Executive producer: Dr. Patrick Beeman

A podcast from Ars Longa Media

---

This is Addiction Medicine Journal Club with Dr. Sonya Del Tredici and Dr. John Keenan. We practice addiction medicine and primary care, and we believe that addiction is a disease that can be treated. This podcast reviews current articles to help you stay up to date with research that you can use in your addiction medicine practice.



The best part of any journal club is the conversation. Send us your comments on social media or join our Facebook group.

---

Email: addictionmedicinejournalclub@gmail.com

Facebook: @AddictionMedJC

Facebook Group: Addiction Medicine Journal Club

Instagram: @AddictionMedJC

Threads: @AddictionMedJC

YouTube: addictionmedicinejournalclub

Twitter/X: @AddictionMedJC

---

Addiction Medicine Journal Club is intended for educational purposes only and should not be considered medical advice. The views expressed here are our own and do not necessarily reflect those of our employers or the authors of the articles we review. All patient information has been modified to protect their identities.

Learn more about your ad choices. Visit megaphone.fm/adchoices