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Science Savvy

fairleycarmen9
Science Savvy
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  • You will Never Forget this Episode: Science of Memory
    In this episode of Science Savvy, I explore how memory shapes identity and human culture. The episode covers the evolutionary origins of memory, the brain regions involved, how memories are encoded, and how therapies (including MDMA) can help heal traumatic memories. You will also get practical tips to improve your memory! About Science Savvy: My name is Carmen Fairley, I have a background in pharmacology and biomedical engineering, and currently work in medical advisory. Science Savvy is a podcast that makes cutting-edge research accessible, turning complex science into stories that mean something for you. Citations / Bibliography: Chudek, Maciej, and Joseph Henrich. “Culture-gene coevolution, norm-psychology and the emergence of human prosociality.” Trends in cognitive sciences vol. 15,5 (2011): 218-26. doi:10.1016/j.tics.2011.03.003 Brockmeier, Jens. “Memory, Narrative, and the Consequences.” Topics in cognitive science vol. 11,4 (2019): 821-824. doi:10.1111/tops.12412 Sridhar, S., et al. Cognitive neuroscience perspective on memory. PMC 2023 Markowitsch, H. J. Memory and Self–Neuroscientific Landscapes. PMC 2013 D’Argembeau, A., et al. Brains creating stories of selves: the neural basis of autobiographical reasoning. PMC 2013 Martinelli, P., et al. Neural substrates of the self‑memory system: New insights. PMC 2012 Richerson, P. J., & Boyd, R. Gene‑culture coevolution in the age of genomics. PMC 2010 Strikwerda‑Brown, C., et al. “All is not lost” – Rethinking the nature of memory and self in dementia. PMC 2019 Repetto, C., et al. The neuroscience of body memory: Recent findings and implications. PMC 2023 Dégeilh, F., et al. Neural correlates of Self and its interaction with memory in adolescence. PMC 2015 Pais‑Vieira, C., et al. The influence of self‑awareness on emotional memory. PMC 2015
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  • Cris Cancer: Who is funding tomorrow's cancer cure?
    In this episode of Science Savvy, I sit down with Elena Muyo, Scientific Projects & Partnerships Lead at CRIS Cancer UK, to uncover how this unique charity is rewriting the future of cancer research. From dual CAR-T trials in children with leukemia, to a first-in-class lung cancer vaccine, to pioneering treatments for devastating childhood brain tumors, CRIS Cancer is driving science that gives patients options when medicine says “there’s nothing more we can do.” We talk about the incredible story that started it all, how CRIS selects and funds projects that others overlook, and why every pound donated has a multiplying effect on hope and discovery. If you’ve ever wondered how patient-driven science can change the course of cancer treatment, this is the episode for you. About Science Savvy: My name is Carmen Fairley, I have a background in pharmacology and biomedical engineering, and currently work in medical advisory. Science Savvy is the podcast that makes cutting-edge research accessible, turning complex science into stories that mean something for you. Citations / Bibliography: National Cancer Institute. What Is CAR T-Cell Therapy? cancer.gov Maude SL, Frey N, Shaw PA, et al. Chimeric antigen receptor T cells for sustained remissions in leukemia. New England Journal of Medicine. (also available via PMC) Fesnak AD, June CH, Levine BL. Engineering T cells: the intersection of synthetic biology and adoptive cell therapy. Nature Reviews Cancer. June CH, Sadelain M. Chimeric antigen receptor therapy. New England Journal of Medicine. Newick K, Moon E, Albelda SM. CAR T cell therapy for solid tumors. Annual Review of Medicine. Frontiers in Immunology / Frontiers in Oncology. Articles on CAR-T in solid tumors and tumor microenvironment challenges. Cancer Research UK / CRIS Cancer Foundation. LungVax project announcement. news.cancerresearchuk.org Elliott T (et al.). Details of neoantigen-based lung cancer vaccine design (as reported by CRUK) BioNTech / mRNA vaccine clinical trial reports (e.g., BNT116 in lung cancer). PMC articles / reviews on checkpoint inhibitors in lung cancer (e.g. anti‑PD‑1 / anti‑PD‑L1 therapies). Frontiers in Immunology / Frontiers in Oncology – studies combining immunotherapy in thoracic cancers, mechanisms of resistance, tumor microenvironment. National Cancer Institute / NIH press / Cancer Currents. CAR T trial in DMG. Studies on ONC201 in H3K27M mutant gliomas (e.g. University of Michigan / clinical trial reports). Reviews of prognosis and therapeutic challenges in diffuse midline glioma (e.g., clinical trial databases, Pediatric Neuro‑Oncology journals). American Cancer Society / Cancer.org. Overview of Clinical Trial Phases. Cancer Research UK. Explanation of how clinical trials work, purposes of phases I, II, III. Lupus Research / NIH / NCI / adaptive trial methodology sources. Phase I/II and Phase II/III design explanations.
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  • Science Savvy Has Great Genes: Genetics of Schizophrenia with Aitana Padilla
    In this episode we talk about "having great genes", but also weird ones, ancient viral ones, and even one named after Sonic Hedgehog (look it up!). W dive into how your DNA is more like a script with a dimmer switch than a fixed destiny. From epigenetics and retroviruses to schizophrenia research, stem cells, and the pitfalls of 23andMe, we explore the science written into your genome. Thank you to Aitana Padilla for coming on the show. Aitana is a neuroscientist in training with a deep focus on the genetics of mental health. She currently investigates how human endogenous retroviruses (remnants of ancient viral infections embedded in our DNA) may influence schizophrenia!   Further reading and references: Human Endogenous Retroviruses as Pathogenic Factors in Schizophrenia: Slokar G, Hasler G. Front Psychiatry. 2016;6:183. doi:10.3389/fpsyt.2015.00183. Implication of human endogenous retroviruses in schizophrenia and bipolar disorder: Ellul P, Groc L, Leboyer M. Med Sci (Paris). 2017;33(4):404-409. doi:10.1051/medsci/20173304010. Heritability of Schizophrenia and Schizophrenia Spectrum Based on the Nationwide Danish Twin Register: Hilker R et al. Biol Psychiatry. 2018;83(6):492-498. doi:10.1016/j.biopsych.2017.08.017. Schizophrenia as a Complex Trait: Evidence from a Meta-analysis of Twin Studies: Sullivan PF et al. Arch Gen Psychiatry. 2003;60(12):1187-1192. doi:10.1001/archpsyc.60.12.1187. Huntington's Disease: A Clinical Review: Roos RA. Orphanet J Rare Dis. 2010;5:40. doi:10.1186/1750-1172-5-40. The Relationship Between Cannabis Use, Schizophrenia, and Bipolar Disorder: A Genetically Informed Study: Cheng W et al. Lancet Psychiatry. 2023;10(6):441-451. doi:10.1016/S2215-0366(23)00143-8. Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors: Takahashi K et al. Cell. 2007;131(5):861-872. doi:10.1016/j.cell.2007.11.019. Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors: Takahashi K, Yamanaka S. Cell. 2006;126(4):663-676. doi:10.1016/j.cell.2006.07.024. Animal Models of CNS Disorders: McGonigle P. Biochem Pharmacol. 2014;87(1):140-149. doi:10.1016/j.bcp.2013.06.016. Advances Toward Precision Medicine for Bipolar Disorder: Haggarty SJ et al. Mol Psychiatry. 2021;26(1):168-185. doi:10.1038/s41380-020-0831-4.
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  • Genetics: You Are More Viral Than You Think
    Welcome to the Genetics episode, part of Science Savvy with Carmen. In this episode, I am joined by neuroscientist and PhD researcher Aitana Padilla Requerey. Leveraging my background in pharmacology and biomedical engineering, I speak with Aitana to better understand gene expression, viral DNA, and genetic editing. This episode covers the role of ancient viral elements embedded in our genome, how epigenetics acts like a dimmer switch on gene activity, and how genetic tools like CRISPR are changing the future of medicine. Aitana earned her Bachelor of Science in Neuroscience from UCLA, graduating with a perfect 4.0 GPA and conducting research on Multiple Sclerosis using advanced lab techniques. She went on to complete a Master of Science in Clinical Neuroscience at UCL, where she worked on mouse models to investigate molecular systems involved in antiviral responses and their relevance to diseases like Alzheimer’s. Now, as a PhD candidate, she’s investigating how ancient viruses embedded in our DNA may influence the development of schizophrenia, bridging genetics, virology, and psychiatry in her groundbreaking research. Whether you’re curious about DNA, mental health, or how the environment shapes your biology, this episode offers clear and engaging insights grounded in real research. Science Savvy helps you understand the systems shaping your thoughts, health, and behavior. If you're ready to explore your body and brain with a little more clarity, you're in the right place. Further reading and references: Bohacek, J., & Mansuy, I. M. (2015). Epigenetic inheritance of disease and disease risk. Neuropsychopharmacology, 40(1), 245–262. https://pubmed.ncbi.nlm.nih.gov/20643310/ Champagne, F. A., & Curley, J. P. (2009). Epigenetic mechanisms mediating the long-term effects of maternal care on development. Neuroscience & Biobehavioral Reviews, 33(4), 593–600. https://pubmed.ncbi.nlm.nih.gov/20363720/ Feil, R., & Fraga, M. F. (2012). Epigenetics and the environment: Emerging patterns and implications. Nature Reviews Genetics, 13(2), 97–109. https://pubmed.ncbi.nlm.nih.gov/22906839/ Muller, P. A. J., & Vousden, K. H. (2014). Mutant p53 in cancer: New functions and therapeutic opportunities. Cancer Cell, 25(3), 304–317. https://pubmed.ncbi.nlm.nih.gov/30538286/ Mantovani, F., & Collavin, L. (2024). TP53 mutations in cancer: Molecular features and therapeutic implications. Molecular Oncology. https://pubmed.ncbi.nlm.nih.gov/39450536/ Balestrieri, E., et al. (2011). Human endogenous retrovirus type W (HERV-W) in schizophrenia. Current Issues in Molecular Biology, 14(3), 123–130. https://pubmed.ncbi.nlm.nih.gov/21936762/ Frank, O., et al. (2005). Human endogenous retrovirus expression in brains of patients with schizophrenia and bipolar disorders. Journal of Virology, 79(17), 10890–10901. https://pubmed.ncbi.nlm.nih.gov/26793126/ Ripke, S., et al. (2014). Biological insights from 108 schizophrenia-associated genetic loci. Nature, 511(7510), 421–427. https://pubmed.ncbi.nlm.nih.gov/25056061/ Sullivan, P. F., et al. (2018). Genetic architectures of psychiatric disorders. Nature Reviews Genetics, 19(8), 537–551. https://pubmed.ncbi.nlm.nih.gov/31780348/ Chiang, C., et al. (1996). Cyclopia and defective patterning in mice lacking Sonic hedgehog. Nature, 383(6599), 407–413. https://pubmed.ncbi.nlm.nih.gov/9205942/ Briscoe, J., & Small, S. (2015). Sonic Hedgehog signaling in neural tube patterning. Development, 142(21), 3771–3780. https://pubmed.ncbi.nlm.nih.gov/36672161/ Takahashi, K., & Yamanaka, S. (2006). Induction of pluripotent stem cells by defined factors. Cell, 126(4), 663–676. https://pubmed.ncbi.nlm.nih.gov/16904174/ Okita, K., et al. (2011). Integration-free human iPS cell generation. Nature Methods, 8(5), 409–412. https://pubmed.ncbi.nlm.nih.gov/26883003/ Bosley, K. S., et al. (2015). CRISPR germline engineering—The community speaks. Nature Biotechnology, 33(5), 478–486. https://pubmed.ncbi.nlm.nih.gov/28879860/ Brokowski, C., & Adli, M. (2019). CRISPR ethics: Moral considerations. Journal of Molecular Biology, 431(1), 88–101. https://pubmed.ncbi.nlm.nih.gov/29885329/ Hogarth, S., et al. (2008). Direct-to-consumer genetic testing: Legal, ethical, and policy issues. Annual Review of Genomics and Human Genetics, 9, 161–182. https://pubmed.ncbi.nlm.nih.gov/18852208/
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  • Built to Be Mid: The Evolutionary Problem With Happiness
    Welcome to this Science Savvy episode on Happiness. In this episode, I explore what happiness really is from a neuroscience & evolutionary perspective, and explain why it’s a biological miracle that we feel joy at all. I have a background in pharmacology and biomedical engineering, and in this episode I cover why dopamine gets all the hype (but shouldn’t), how gratitude rewires your brain, why you’re not supposed to be happy all the time, and what Tibetan monks can teach us about brain waves and contentment. Science Savvy helps you understand the systems shaping your thoughts, health, and behavior. If you're ready to explore your body and brain with a little more clarity, you're in the right place. Further reading and references: Farhud, D. D., Malmir, M., & Khanahmadi, M. (2014). Happiness & Health: The Biological Factors – Systematic Review. Iranian Journal of Public Health, 43(11), 1468–1477. (Overview of genetic, neurochemical, hormonal, and health correlates of happiness)​ Machado, L., & Cantilino, A. (2017). A systematic review of the neural correlates of positive emotions. Brazilian Journal of Psychiatry, 39(2), 172–179. (Review finding increased left frontal and decreased right frontal activity, among other regions, during happiness)​ Tan, J. J. X., Kraus, M. W., Carpenter, N. C., & Adler, N. E. (2020). The association between objective and subjective socioeconomic status and subjective well-being: A meta-analytic review. Psychological Bulletin, 146(11), 970–1020. (Meta-analysis of 335 studies; reports an average income-happiness correlation of ~0.23)​ Killingsworth, M. A. (2021). Experienced well-being rises with income, even above $75,000 per year. Proceedings of the National Academy of Sciences, 118(4), e2016976118. (Large experience-sampling study showing no plateau in happiness up to ~$200k, though marginal gains diminish at higher incomes)​ Diener, E., & Seligman, M. E. P. (2002). Very happy people. Psychological Science, 13(1), 81–84. (Study of characteristics of extremely happy individuals – they had strong social relationships as the most notable common feature) Fredrickson, B. L. (2001). The role of positive emotions in positive psychology: The broaden-and-build theory of positive emotions. American Psychologist, 56(3), 218–226. (Seminal theory paper proposing that positive emotions broaden cognitive-behavioral repertoires and build lasting resources)​ Coles, N. A., Larsen, J. T., & Lench, H. C. (2019). A meta-analysis of the facial feedback literature: Effects of facial feedback on emotional experience are small and variable. Psychological Bulletin, 145(6), 610–651. (Meta-analysis confirming that while facial expressions do influence feelings, the effects are modest)​ Cregg, D. R., & Cheavens, J. S. (2021). Gratitude interventions: Effective self-help? A meta-analysis of the impact on symptoms of depression and anxiety. Journal of Happiness Studies, 22(2), 413–445. (Meta-analysis of 27 studies showing gratitude exercises reliably improve well-being and reduce depressive symptoms)​ Moll, J., et al. (2006). Human fronto–mesolimbic networks guide decisions about charitable donation. Proceedings of the National Academy of Sciences, 103(42), 15623–15628. (fMRI study demonstrating that donating to charity activates the brain’s reward circuits similarly to receiving a monetary reward)​ Lutz, A., Greischar, L. L., Rawlings, N. B., Ricard, M., & Davidson, R. J. (2004). Long-term meditators self-induce high-amplitude gamma synchrony during mental practice. Proceedings of the National Academy of Sciences, 101(46), 16369–16373. (Research on Buddhist monks showing meditation can produce intense gamma wave synchrony, linked to positive emotional states)​ Helliwell, J. F., Huang, H., Wang, S., & Norton, M. (2023). World Happiness Report 2023. New York: Sustainable Development Solutions Network. (Annual report that uses Gallup data to rank countries by happiness and analyzes factors like GDP, social support, healthy life expectancy, freedom, generosity, and corruption)​ ​ Young, S. N. (2007). How to increase serotonin in the human brain without drugs. Journal of Psychiatry & Neuroscience, 32(6), 394–399. (Review of the relation between serotonin and mood, noting that positive mood is associated with higher serotonin function and discussing non-pharmacological ways to boost serotonin, like sunlight and exercise)​ And my personal fave: worldhappiness.report
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Welcome to Science Savvy, where I, Carmen Fairley, leverage my background in Pharmacology and Biomedical Engineering to explore the extraordinary science behind everyday life. I want you to fall in love with science like I did, and realise it doesn't have to be inaccessible jargon. We cover topics from interviews with researchers at the forefront of healthcare, through to mental health, and even topics around love, friendship, and family, to help YOU see that cool science is EVERYWHERE. New episodes every two Fridays. Follow now and never miss an episode!
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