
Serena Williams and Oprah on Deciding to Take GLP-1 Medications
13-1-2026 | 1 u. 10 Min.
For her most of her adult life, Oprah has struggled with her weight. She never dreamed in her lifetime, there would be medications that could help her as well as millions of others. On this episode of The Oprah Podcast, Oprah is joined by Dr. Ania Jastreboff, leading endocrinologist and associate professor at Yale School of Medicine in front of a live audience in New York City. They discuss Dr. Ania’s new book, Enough: Your Health, Your Weight, and What It's Like To Be Free which delivers a deeply transformational message: there is a path to healing from the blame and shame of obesity to lead the life you have always wanted. Dr. Jastreboff shares the science behind why obesity is a disease and not a question of willpower and why the new medications have been so effective for tens of millions of people. Oprah shares her decades-long public struggle with her weight and reveals how her experience with a GLP-1 medication has given her a freedom and energy she never thought possible. Plus, 23-time grand slam tennis champion Serena Williams joins the conversation and opens up about her own battle with weight calling it “the one opponent she couldn't defeat.” Serena also reveals why - after her initial skepticism - she decided to start a GLP-1 medication. Finally, we hear from guests in the audience about how the GLP-1 medications have changed their lives. One of those guests is Stedman Graham’s nephew Julius who shares with heartbreaking honesty how his weight held him back for decades. He says that after losing 64 pounds on a GLP-1 medication he is now “fully alive.” BUY THE BOOK! https://www.simonandschuster.com/books/Enough/Ania-M-Jastreboff/9781668217283 00:00:00 - Welcome Dr. Ania Jastreboff, author of “Enough” 00:01:30 - 74% of americans are overweight 00:04:30 - Obesity is a disease 00:07:30 - We live in an obesogenic environment 00:09:10 - Genetic link to obesity 00:10:50 - You can’t willpower away obesity 00:13:30 - Defining food noise 00:18:30 - Recalibrating your “enough point” 00:22:30 - Some people have food noise, others don’t 00:23:40 - Welcome Serena Williams 00:27:00 - Why Serena tried GLP-1s 00:29:30 - Everyone responds to GLP-1s differently 00:31:00 - How Serena feels on GLP-1s 00:40:00 - Why your body settles on an unhealthy “enough point” 00:42:00 - Welcome Julius, Stedman’s nephew 00:50:00 - How GLP-1s changed Julius 00:54:00 - Do you stay on GLP-1s forever? 01:02:00 - Can GLP-1s prevent obesity? 01:04:00 - Oprah wants GLP-1s available to all 01:05:40 - Dr. Ania wants people to understand obesity Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

What Is Your Full Potential — with Adam Grant and Oprah
06-1-2026 | 46 Min.
Oprah sits down with renowned organizational psychologist and professor Adam Grant to talk about lessons from his latest #1 New York Times bestselling book "Hidden Potential: The Science of Achieving Greater Things.” Known for his research on human potential, Grant shares how anyone can achieve greatness and unlock potential by cultivating character traits like resilience, curiosity, perseverance and embracing discomfort. He shares personal stories of overcoming his own limitations and insights from people who’ve accomplished the extraordinary. Joining the conversation is the first Black Chess Grandmaster Maurice Ashley and people from around the country via Zoom who desire to harness the power of hidden potential. BUY THE BOOK! 'Hidden Potential: The Science of Achieving Greater Things' by Adam Grant:https://www.penguinrandomhouse.com/books/719611/hidden-potential-by-adam-grant/ Adam Grant 2026 Day-to-Day Calendar: Something to Think About: Daily Insight from the Psychologist and Author https://www.amazon.com/Adam-Grant-2026-Day-Calendar/dp/152489933X Adam Grant: https://adamgrant.net/about/biography/ 00:00:00 - Welcome Adam Grant, author of Hidden Potential 00:04:13 - How character and personality differ 00:06:10 - Action and confidence 00:09:00 - Critics as coaches 00:11:50 - Standing in your values 00:14:15 - What makes a good leader 00:17:18 - First Black Chess Grandmaster Maurice Ashley 00:22:45 - How potential gets overlooked 00:24:10 - How ‘Hidden Potential’ helps educators 00:27:30 - Three priorities for a school to thrive 00:30:25 - Tap into your hidden potential 00:33:28 - Confidence in your ability to learn 00:34:50 - Managing perfectionism 00:38:00 - Appreciate your progress 00:39:30 - What keeps Oprah motivated 'Move by Move: Life Lessons on and Off the Chessboard' by Maurice Ashley:https://mauriceashley.com/move-by-move/ Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

Oprah and Iyanla Vanzant on Daily Care for Your Spiritual Hygiene
30-12-2025 | 58 Min.
Oprah sits down with world-renowned spiritual teacher, bestselling author and “fixer" Iyanla Vanzant for a powerful, soul-shifting conversation about her newest book "Spiritual Hygiene: A Practical Path for Clean Living, for Inner Authority, and for Divine Freedom." In this intimate and deeply personal episode Iyanla explains the transformative concept of spiritual hygiene—the idea that just as we tend to our physical hygiene our mental, emotional and spiritual well-being also require conscious, daily care. Iyanla shares what she’s learned and how she’s healed from her own childhood trauma as well as losing two of her adult daughters, Gemmia in 2003 and Nisa in 2023. Oprah and Iyanla are joined by audience members who bravely ask how they can cleanse their spirits of the pain, heaviness and generational burdens they’ve carried throughout their lives. Together they explore how spiritual hygiene offers clarity, courage and a way forward. This episode is a moving invitation to let go and step into a more grounded, spiritually spacious life. BUY THE BOOK! https://www.simonandschuster.com/books/Spiritual-Hygiene/Iyanla-Vanzant/9781668214121 00:00:00 - Welcome Iyanla Vanzant, author of ‘Spiritual Hygiene’ 00:03:40 - Meaning of spiritual hygiene 00:04:15 - Iyanla’s backstory 00:11:08 - The power of grief 00:13:30 - Parenting with spiritual hygiene 00:14:00 - Iyanla says she was a horrible mother 00:15:25 - The distinction between wrong and bad 00:17:50 - The meaning of divine freedom 00:19:00 - Everything is energy 00:20:30 - Healing the pain of being a daddy-less daughter 00:30:20 - Create your own spiritual hygiene 00:33:15 - How to be expressive with family 00:37:40 - Reorder your story 00:38:10 - The life you signed up for 00:40:00 - Look at far you’ve come 00:41:40 - The guilt of choosing yourself 00:46:15 - Always choose yourself 00:48:02 - A sacred no and a spiritual yes 00:52:00 - Everything has a purpose Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

Oprah with Jeremy Allen White & Scott Cooper on Creating Springsteen: Deliver Me from Nowhere
23-12-2025 | 36 Min.
Oprah sits down with actor Jeremy Allen White and writer-director Scott Cooper for a fascinating conversation about their stirring new film, Springsteen: Deliver Me from Nowhere. The film is a revelatory look at Bruce Springsteen during a personal and professional crossroads; the film explores the mental health struggles and creative reckoning behind the making of his deeply personal album Nebraska. Oprah calls White’s Golden Globe–nominated performance “mesmerizing” and praises Cooper for “elevating quiet struggle into cinematic poetry,” describing the film as “a gift” and a meditation on “what it means to be human.” The film also stars Jeremy Strong, Odessa Young, Stephen Graham, Johnny Cannizzaro, Gaby Hoffman, Paul Walter Hauser and Grace Gummer. SEE THE FILM! Springsteen: Deliver Me from Nowhere, starring Golden Globe nominee Jeremy Allen White, written and directed by Scott Cooper, and distributed by 20th Century Studios is now available on Demand. https://tv.apple.com/us/movie/springsteen-deliver-me-from-nowhere/umc.cmc.44ij3fzlajh43wxngtyxd6ioi 00:00:00 - Oprah introduces the movie Springsteen: Deliver Me From Nowhere 00:03:22 - Oprah, Jeremy Allen White and Scott Cooper at Santa Barbara Film Festival 00:05:00 - Jeremy on getting cast as Bruce Springsteen 00:06:30 - Scott on telling Springsteen’s story 00:08:35 - Scott on asking Bruce to make this film 00:12:00 - How Jeremy prepared to become Bruce Springsteen 00:14:50 - Jeremy on learning guitar 00:18:20 - Scott on using black and white photography for flashbacks 00:25:27 - How playing Springsteen changed Jeremy 00:28:10 - Scott on how making the movie changed him 00:29:10 - Springsteen and mental illness Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices

Oprah with Hugh Jackman & Kate Hudson & Their Movie You Have to See this Christmas
16-12-2025 | 58 Min.
Academy Award-nominated actors Hugh Jackman and Kate Hudson join The Oprah Podcast to discuss their upcoming extraordinary film Song Sung Blue which will be released in theaters on December 25. Song Sung Blue is a deeply moving love story about dreams and second chances. Based on a true story, Hugh and Kate portray the Milwaukee couple Mike and Claire Sardina, who were the legendary Neil Diamond tribute band duo known as "Lightning & Thunder.” The film is also an homage to Neil Diamond’s beloved catalogue of iconic songs. The podcast was recorded with a live audience who screened the film in New York City. The episode also features a surprise guest from Kate Hudson’s past, a Zoom surprise with viewers in Milwaukee and questions from the audience. Song Sung Blue In theaters everywhere Christmas Day. https://www.focusfeatures.com/song-sung-blue 00:00:00 - Welcome Hugh Jackman and Kate Hudson, stars of Song Sung Blue 00:00:00 - Song Sung Blue movie preview 00:04:50 - Hugh Jackman on the Lightning and Thunder documentary 00:08:00 - Hugh and Kate react to reviews 00:10:15 - Oprah shares her love for Neil Diamond 00:11:48 - Movie clip 00:13:06 - How Hugh prepared to be a Neil Diamond impersonator 00:14:00 - Neil Diamond’s reaction to the movie 00:16:35 - Kate on her singing role 00:19:50 - On doing a Wisconsin accent 00:22:22 - Oprah surprises Kate Hudson 00:25:00 - Hugh Jackman on working with Kate Hudson 00:26:30 - Movie clip 00:29:50 - How the movie inspires 00:33:50 - The characters struggle with substance abuse 00:34:45 - How Hugh and Kate developed on-screen chemistry 00:39:20 - Hugh on his performance 00:39:55 - Movie clip 00:44:03 - Oprah surprises Lightning and Thunder fans 00:51:58 - Hugh shares Neil Diamond story Song Sung Blue (2008) A Documentary by Greg Kohs http://watch.songsungblue.com Follow Oprah Winfrey on Social: https://www.instagram.com/oprahpodcast/ https://www.facebook.com/oprahwinfrey/ Listen to the full podcast: https://open.spotify.com/show/0tEVrfNp92a7lbjDe6GMLI https://podcasts.apple.com/us/podcast/the-oprah-podcast/id1782960381 Learn more about your ad choices. Visit megaphone.fm/adchoices



The Oprah Podcast