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From First Principles

Lester Nare and Krishna Choudhary
From First Principles
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  • FFP EP. 9 | China’s AI Breakthrough, Time Crystals, Hidden Viruses, & Brightest Cosmic Signal
    Lester Nare and Krishna Choudhary return for Episode 9 of From First Principles, breaking down the latest breakthroughs across AI, physics, biology, and astronomy. From China’s stunning AI leap with DeepSeek to time crystals you can actually see, hidden viruses in our DNA, and the brightest fast radio burst ever detected—this episode spans the cutting edge of science and its global implications.Summary• China’s DeepSeek AI model: geopolitics, open science, and the future of AI competition• Time crystals at room temperature: from theoretical physics to practical cryptography• Hidden viruses in our DNA: new structures decoded with potential for cancer & autoimmune therapies• Brightest fast radio burst: unraveling cosmic mysteries with new telescopes and James WebbShow Notes• Nature: China’s DeepSeek AI paper (1)• Nature: China’s DeepSeek AI paper (2)• Nature: Time crystals with liquid crystals• Science Advances: Viral protein structure discovery• Astrophysical Journal Letters: Brightest FRB
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  • FFP Story — JWST Detects Signs of Atmospheres on Earth-Sized Exoplanets (EP. 8)
    Hosted by Lester Nare and Krishna Choudhary, this story unpacks brand-new Astrophysical Journal Letters results from JWST hinting at atmospheres on TRAPPIST-1’s Earth-sized planets. We explain how transit spectroscopy works, why TRAPPIST-1 is the perfect laboratory, and what tentative signals of CO₂ and methane could mean for the search for life beyond our solar system.Summary• JWST papers show potential atmospheres on TRAPPIST-1 exoplanets• Transit spectroscopy 101: starlight filtering through atmospheres• Why TRAPPIST-1’s compact system is ideal for repeated measurements• Hints of CO₂ and methane amid noise and systematics• What this implies for habitability and biosignatures• What’s next: better data, better models, and future observatoriesShow Notes• Astrophysical Journal Letters — JWST TRAPPIST-1 Atmosphere Study (Paper 1)• Astrophysical Journal Letters — JWST TRAPPIST-1 Atmosphere Study (Paper 2)
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  • FFP Story — This Exoplanet Made Headlines as the “Strongest Evidence Yet For Life” (EP. 8)
    Hosted by Lester Nare and Krishna Choudhary, this story revisits the April headlines claiming the “strongest evidence yet” for life on exoplanet K2-18b. Cambridge researchers reported dimethyl sulfide (DMS) in the planet’s atmosphere using JWST data and atmospheric retrieval models. We unpack why DMS is exciting on Earth, what Bayesian retrieval actually does, and why multiple teams pushed back—arguing the evidence isn’t at the 5-sigma gold standard and could be explained by other gases or model assumptions.Summary• BBC-style headline: “Strongest evidence yet” for life on K2-18b• Cambridge team reports DMS/DMDS signatures via JWST transit spectra• What DMS means on Earth vs. what it could mean 120 light-years away• How atmospheric retrieval works (and its limits)• Why 3-sigma isn’t enough—calls for caution and alternative fits• Follow-ups suggest a water world; DMS may be abiotic or ambiguous• Big picture: contrast remote spectral “barcodes” with in-situ rover dataShow Notes• Cambridge — K2-18b Atmosphere Study
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  • FFP Story — NASA Finds Potential Biosignatures on Mars (EP. 8)
    Hosted by Lester Nare and Krishna Choudhary, this story covers NASA’s announcement of potential biosignatures on Mars. Perseverance rover data from Jezero Crater revealed unusual nodules containing iron phosphates and iron sulfides, chemical fingerprints often linked to biological activity. While not definitive evidence of life, the finding represents a huge step forward in astrobiology, highlighting why Mars Sample Return is critical for confirmation — and sparking debates in both the scientific community and pop culture.Summary• NASA press conference announces potential biosignatures on Mars• Perseverance rover at Jezero Crater, Bright Angel Formation site• Organic search is difficult — radiation + perchlorates destroy compounds• Scientists instead look for inorganic “life-adjacent” proxies• Discovery: iron phosphates + iron sulfides linked to carbon gradients• Instruments PIXL & SHERLOC confirm unusual mineral chemistry• Debate in Nature peer review: cautious language vs. hype• Historical context: 1996 ALH84001 “life on Mars” meteorite controversy• Why sample return is essential for proof• Funding debate: government + private aerospace collaborationShow Notes• NASA — Mars Biosignature Claim
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  • FFP EP. 8 — Strongest Evidence for Alien Life? (Mars, K2-18b & JWST)
    NASA just dropped what they’re calling the strongest evidence yet for biosignatures on Mars, so we spun up an emergency pod. We break down what the rover actually found in Jezero Crater, why geochemical “life-adjacent” reactions matter, revisit April’s hyped K2-18b claim from Cambridge, and close with brand-new JWST hints of atmospheres on Earth-sized exoplanets. Hosted by Lester Nare and Krishna Choudhary.Summary• NASA’s Mars result — Perseverance, Jezero, Bright Angel Formation, and inorganic proxies for life (iron phosphates/sulfides) plus how instruments like PIXL actually read rocks.• The April headline on K2-18b (“strongest evidence yet”) and what atmospheric retrieval really does and doesn’t prove.• Fresh JWST papers hinting at atmospheres on TRAPPIST-1 worlds — why that’s huge and how transit spectroscopy underpins it.Show Notes• NASA — Mars Biosignature Claim• Cambridge — K2-18b Atmosphere Study• Astrophysical Journal Letters — JWST TRAPPIST-1• Atmosphere Study (Paper 1)• Astrophysical Journal Letters — JWST TRAPPIST-1 Atmosphere Study (Paper 2)
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