From the Spectrum: Finding Superpowers with Autism

• Spindle Neurons, Salience Network, & Social Behaviors

  In this episode we explore spindle neurons, also known as von Economo neurons (VENs), discovered by Constantine von Economo in the 1920s. These large, cylinder-shaped cells, found in the anterior cingulate cortex (ACC), anterior (or called frontoinsula) insula, and rarely the dorsolateral prefrontal cortex (DLPFC), are crucial for rapid communication in social behaviors. Three key points stand out: first, spindle neurons are located exclusively in the ACC and insula, the core hubs of the salience network, which is disrupted in autism as early as six weeks of age, as shown in a UCLA study. Second, these neurons are primarily involved in social behaviors, underpinning complex interactions in humans and other social species. Third, they are rare, found only in highly social animals like great apes, cetaceans, and possibly elephants, highlighting their evolutionary significance. In autism, increased spindle neuron density in the insula of children aged 4–14 is linked to early brain overgrowth, though this normalizes in adulthood due to pruning.The salience network, driven by the ACC and anterior insula, relies on spindle neurons to process relevant stimuli, integrate sensory data, and guide social-emotional responses. In autism, hyper-connectivity between the insula and sensory regions causes sensory hypersensitivity, while hypo-connectivity with prefrontal areas, including the DLPFC, impairs social cognition and adaptive behaviors. This disrupts the network’s ability to switch between the default mode network and executive functions, often trapping autistic individuals in an internal world. Spindle neurons are also linked to disorders like frontotemporal dementia, schizophrenia, Alzheimer’s, and emotional dysregulation.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism0:00 Chroma Light Devices, use "autism" for 10% discount3:10 Spindle Neurons; Interesting Point #1: Salience Network6:03 Interesting Point #2: Rapid Communication & Social Behaviors7:11 "rediscovery" of Spindle Neurons in 1990s by John Allman8:30 Interesting Point #3: Highly Social Species10:57 Neuropeptide Y & Monoamine- Dopamine & Serotonin11:45 Morphology of Spindle Neurons & In Utero-Children; Social Learning12:54 Species with Spindle Neurons14:47 Small Clusters within the dlPFC15:08 Salience Network, ACC, Anterior Insula; Fulcrum for Default Mode and Executive Networks22:48 Daylight Computer Company, use "autism" for $25 discount27:08 Diseases/Conditions associated with Spindle Neurons29:26 The Autistic Phenotype (!!) -- The Whole Reason for the Podcast32:25 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  33:20
• (Re-Release) Dr. Catherine Lord: The Evolution of Autism Assessment, Challenges with Understanding the Spectrum of Autism, and Barriers in the Medical and Education Systems for Autism

  In this episode, we discuss Autism with Dr. Catherine Lord. Dr. Lord is a Distinguished Professor of Psychiatry and Education at UCLA and one of the foremost researchers in Autism. Dr. Lord provides tremendous insights into her roles in Autism and Autism Assessment.Dr. Lord discusses her journey into Autism, the evolution of the Assessment including the ADOS growing from her basement and being overran by demand to the Gold Standard, the Challenges with understanding the Spectrum, updates on the Lancet Commission and Profound Autism, and Barriers in the Medical and Educational Systems.https://www.semel.ucla.edu/autism/team/catherine-lord-phdhttps://childmind.org/bio/catherine-lord-phd/https://labs.dgsom.ucla.edu/lord/pages/our_teamAutism and Education https://podcasts.apple.com/us/podcast/from-the-spectrum-finding-superpowers-with-autism/id1737499562?i=1000656055638The mention of a recent article on Predicting Profound Autism and Cell Biology and me shying away from saying "Organoids" in real-time https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11127428/Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism(0:00) Intro(3:22) Dr. Lord's journey into Autism and Recognizing a Spectrum(11:25) The Evolution of Autism Assessment and Discussion on the ADI and ADOS- from making the ADOS in her Basement and being Overran by Demand to the Gold Standard; Revisions of Assessment Instruments(16:36) Gaps in the Autism Assessment(23:15) The Challenges with Understanding the Spectrum of Autism(29:32) Updates on the Lancet Commission and Profound Autism(35:19) Barriers with Autism and the Medical Field(39:29) Barriers with Autism and Education- Four Strikes against the Autistic Phenotype: Sensory-Processing, Speech and Language, Social Communication/Interaction, and Subject Switching (understand B3: Fixated Interests)(44:25) The Future of Autism and Helping Autistics Across the Life Span(51:03) Reviews/Ratings and Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  51:39
• Leptin, Biophotons, & Autism's Development

  In this episode, we explore the impact of tech use and blue light on circadian biology, exploring how melanopsin and chromophores regulate physiology, mood, and cell functioning. The discussion highlights the leptin-melanocortin pathway, its role in placental physiology, and how ultra-weak biophotons from placental mitochondrial DNA influence fetal development, emphasizing the critical interplay of light and dark cycles in health.We further examine fetal brain development, focusing on mitochondria, neurogenesis, and the effects of UV light and nitric oxide on the thalamus and sensory integration. The episode connects BH4, tryptophan, and melanin deficits to Autism, discussing how environmental light and electromagnetic fields disrupt biological energy, contributing to neurodevelopmental problems and the Autistic phenotype.Daylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 Daylight Computer Company, use "autism" for $25 discount04:17 leptin-melanocortin pathway, biophotons, mitochondria, POMC, nitric oxide, BH4, fetal, placental physiology, fertility, ultra-weak biophotons, maternal blood, quantum biology, melanin, UV08:00 endocannabinoid, UV light, 380 nanometer, melanopsin, photo switch, brain development, leptin, mTOR, mitochondria, thalamus, sensory integration center, neurogenesis, fetal thalamus12:00 nitric oxide, autism, BH4, fetal ATP production, tryptophan, cellular redox, BPA, fluoride, deuterium absorption, electromagnetic fields, semiconduction, brain growth, biological energy16:03 Chroma Lights for Humans, use "autism" for 10% discount20:04 leptin-melanocortin pathway, leptin, adipose tissue, melanopsin, hypothalamus, POMC, placental physiology, ultra-weak biophotons, melanin, semiconductor, antioxidant, maternal physiology, brain volume24:23 biophotons, living cells, mitochondrial activity, cellular communication, electromagnetic waves, UV light wavelengths, energy, mitochondria, reactive oxygen species, TCA cycle, placental efficiency, thalamic timing28:29 mitochondrial DNA, retrograde signaling, gene expression, environmental cues, autism, heteroplasmy, biophoton coherence, calcium release, acetyl coenzyme A, fetal thalamus, neurogenesis, environmental light32:29 leptin-melanocortin pathway, neurodevelopmental problems, biophotons, somnathogenesis, circadian abnormalities, melanin, neural semiconduction, hyper excitability, hyper connectivity, salience network, attention, autistic phenotype36:34 Reviews/Ratings, Contact InfoX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  38:23
• Katie Asher: Understanding Communication, Telepathy, and Spiritual Existence

  My guest today is a special Mother's Day edition with Katie Asher. Katie is a devoted mother of five and founder of Asher House, who shares her inspiring journey of raising her son Houston, who has severe autism. Katie discusses the challenges of navigating trauma, loss, and an abusive past, all while advocating for Houston’s voice through groundbreaking communication methods like letter boards. She recounts the transformative moment when Houston, previously nonverbal, began spelling to communicate, revealing his profound intelligence and telepathic abilities, which reshaped her worldview and deepened their spiritual connection. Their story, detailed in their co-authored book The Book of Heaven, highlights resilience, faith, and the fight for recognition and inclusion for non-speaking individuals.Katie also critiques systemic failures in education and healthcare, exposing how institutions often dismiss the capabilities of those with autism, prioritizing profit over humanity. She passionately advocates for presuming competence, emphasizing the need for trust, love, and proper motor coaching to unlock communication. Through her experiences, Katie calls for a societal shift toward kindness, truth, and justice, urging listeners to value every soul and embrace the spiritual abundance that fosters unity and hope. Join us for an emotional and thought-provoking conversation that challenges assumptions and celebrates the power of connection.Katie Asher X https://x.com/KTAsher5Katie Asher Instagram https://www.instagram.com/asherhousehope/p/DHrUwDtv2R_/?img_index=1Asher House https://www.asher.houseThe Book of Heaven https://www.amazon.com/dp/1737898608DTP Hib https://en.wikipedia.org/wiki/DPT-Hib_vaccineImmune Thrombocytopenic Purpura (ITP) https://en.wikipedia.org/wiki/Immune_thrombocytopenic_purpura0:00 Katie Asher1:33 Katie's Intro into Autism7;24 Challenges with the medical paradigm; Profits over Humanity13:35 Understanding Intelligence & Communication; Telepathy & Sensory Processing25:18 Spelling 2 Communicate31:24 Houston Pops In37:26 Building Trust & Communication Skills46:19 The Instinctual Desire to be Known48:00 Understanding Non-Verbal Communication50:26 The Abundance Mindset51:30 Unity through Truth & Justice52:42 The Struggles of Parents of Autistic Children54:10 The Role of Technology in Communication56:36 The Challenges of Motor Control1:00:00 Eloping & Self-Injurious Behavior; Being drawn to Water1:02:05 The Connection to Water1:03:50 Energy & Spiritual Connection1:05:46 The Role of Humanity in Nature1:07:31 The War between Nature & Machine1:08:35 Telepathy & Communication1:11:43 The Impact of Thoughts on Life1:15:50 Trusting God in Doubt; Contact InformationX: https://x.com/rps47586YT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  1:21:41
• John Coates, RF Safe: The harms of non-native Electromagnetic Fields (nnEMF) and Regulations

  My guest today is John Coates. John is the founder of RFsafe, and he is on a mission from a personal commitment to understand and educate the harms of non-native Electromagnetic Fields. John takes us through a passionate and personal story and educates us on many topics around these modern products. We explore cell phones, microwaves, routers, WIFI, computers, towers, and more. John also educates us about regulation changes such as Section 704 that prevents questioning the health factors related to our modern man-made environment. In addition, John offers a solution to the harms of WIFI by telling us about LIFI, or light fidelity. By the end of this episode, we hope you understand more about health implications related to these non-native EMFs.RF safe https://www.rfsafe.comSection 704 https://www.rfsafe.com/section-704-and-fcc-guidelines-cemented-a-dangerous-wireless-monopoly-at-the-expense-of-health-and-innovation/FCC https://www.fcc.gov/engineering-technology/electromagnetic-compatibility-division/radio-frequency-safety/faq/rf-safetyDaylight Computer Companyuse "autism" for $25 off athttps://buy.daylightcomputer.com/RYAN03139Chroma Iight Devicesuse "autism" for 10% discount athttps://getchroma.co/?ref=autism00:00 John Coates02:20 Personal Mission & Commitment08:14 A fight for change; Policy & Tech11:29 Hidden Dangers of nnEMF14:19 Unconstitutional Laws & Public Health; Protecting Big Tech17:12 The Need for Safer Tech; Section 70420:34 LiFI, Light Fidelity23:20 Environment Emergency in Schools39:37 Evolution of nnEMF & Human Health42:31 nnEMF & Autoimmune Diseases51:45 Bioelectric Dissonance & Development01:03:42 The Role of Natural Environment & Health01:12:48 The Illusion of Safety in Tech01:16:50 Demanding Safer Tech for Children01:21:18 Bioelectric & DNA connection theory01:32:22 The Future of Personalized Health Solutions01:41:00 Scams of SRA; Cancer ratesX: https://x.com/rps47586Hopp: https://www.hopp.bio/fromthespectrumYT: https://www.youtube.com/channel/UCGxEzLKXkjppo3nqmpXpzuAemail: [email protected]

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  1:47:01

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Over From the Spectrum: Finding Superpowers with Autism