How End-to-End Learning Created Autonomous Driving 2.0: Wayve CEO Alex Kendall
Alex Kendall founded Wayve in 2017 with a contrarian vision: replace the hand-engineered autonomous vehicle stack with end-to-end deep learning. While AV 1.0 companies relied on HD maps, LiDAR retrofits, and city-by-city deployments, Wayve built a generalization-first approach that can adapt to new vehicles and cities in weeks. Alex explains how world models enable reasoning in complex scenarios, why partnering with automotive OEMs creates a path to scale beyond robo-taxis, and how language integration opens up new product possibilities. From driving in 500 cities to deploying with manufacturers like Nissan, Wayve demonstrates how the same AI breakthroughs powering LLMs are transforming the physical economy.
Hosted by: Pat Grady and Sonya Huang
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41:36
How Google’s Nano Banana Achieved Breakthrough Character Consistency
When Google launched Nano Banana, it instantly became a global phenomenon, introducing an image model that finally made it possible for people to see themselves in AI-generated worlds. In this episode, Nicole Brichtova and Hansa Srinivasan, the product and engineering leads behind Nano Banana, share the story behind the model’s creation and what it means for the future of visual AI.
Nicole and Hansa discuss how they achieved breakthrough character consistency, why human evaluation remains critical for models that aim to feel right, and how “fun” became a gateway to utility. They explain the craft behind Gemini’s multimodal design, the obsession with data quality that powered Nano Banana’s realism, and how user creativity continues to push the technology in unexpected directions—from personal storytelling to education and professional design. The conversation explores what comes next in visual AI, why accessibility and imagination must evolve together, and how the tools we build can help people capture not just reality but possibility.
Hosted by: Stephanie Zhan and Pat Grady, Sequoia Capital
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OpenAI Sora 2 Team: How Generative Video Will Unlock Creativity and World Models
The OpenAI Sora 2 team (Bill Peebles, Thomas Dimson, Rohan Sahai) discuss how they compressed filmmaking from months to days, enabling anyone to create compelling video. Bill, who invented the diffusion transformer that powers Sora and most video generation models, explains how space-time tokens enable object permanence and physics understanding in AI-generated video, and why Sora 2 represents a leap for video. Thomas and Rohan share how they're intentionally designing the Sora product against mindless scrolling, optimizing for creative inspiration, and building the infrastructure for IP holders to participate in a new creator economy. The conversation goes beyond video generation into the team’s vision for world simulators that could one day run scientific experiments, their perspective on co-evolving society alongside technology, and how digital simulations in alternate realities may become the future of knowledge work.
Hosted by: Konstantine Buhler and Sonya Huang, Sequoia Capital
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Nvidia CTO Michael Kagan: Scaling Beyond Moore's Law to Million-GPU Clusters
Recorded live at Sequoia’s Europe100 event: Michael Kagan, co-founder of Mellanox and CTO of Nvidia, explains how the $7 billion Mellanox acquisition helped transform Nvidia from a chip company into the architect of AI infrastructure. Kagan breaks down the technical challenges of scaling from single GPUs to 100K and eventually million-GPU data centers. He reveals why network performance—not just compute power—determines AI system efficiency. He discusses the shift from training to inference workloads, and his vision for AI as humanity's "spaceship of the mind," and why he thinks AI may help us discover laws of physics we haven’t yet imagined.
Hosted by Sonya Huang and Pat Grady
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Securing the AI Frontier: Irregular Co-founder Dan Lahav
Irregular co-founder Dan Lahav is redefining what cybersecurity means in the age of autonomous AI. Working closely with OpenAI, Anthropic, and Google DeepMind, Dan, co-founder Omer Nevo and team are pioneering “frontier AI security”—a proactive approach to safeguarding systems where AI models act as independent agents.
Dan shares how emergent behaviors, from models socially engineering each other to outmaneuvering real-world defenses like Windows Defender, signal a coming paradigm shift. Dan explains why tomorrow’s threats will come from AI-on-AI interactions, why anomaly detection will soon break down, and how governments and enterprises alike must rethink defenses from first principles as AI becomes a national security layer.
Hosted by: Sonya Huang and Dean Meyer, Sequoia Capital
00:00 Introduction
03:07 The Future of AI Security
03:55 Thought Experiment: Security in the Age of GPT-10
05:23 Economic Shifts and AI Interaction
07:13 Security in the Autonomous Age
08:50 AI Model Capabilities and Cybersecurity
11:08 Real-World AI Security Simulations
12:31 Working with AI Labs
32:34 Enterprise AI Security Strategies
40:03 Governmental AI Security Considerations
43:41 Final Thoughts
Join us as we train our neural nets on the theme of the century: AI. Sonya Huang, Pat Grady and more Sequoia Capital partners host conversations with leading AI builders and researchers to ask critical questions and develop a deeper understanding of the evolving technologies—and their implications for technology, business and society.
The content of this podcast does not constitute investment advice, an offer to provide investment advisory services, or an offer to sell or solicitation of an offer to buy an interest in any investment fund.
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