The Human Upgrade: Biohacking for Longevity & Performance

What if the real reason you feel stuck, anxious, or unfulfilled has nothing to do with your biohacking stack and everything to do with which half of your brain you're actually using? In this episode, Host Dave Asprey sits down with Harvard professor and bestselling author Arthur Brooks to reveal the neuroscience of meaning, consciousness, and why your left brain's obsession with optimization is quietly destroying your happiness and human performance.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
- Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/

Arthur Brooks is a professor at both the Harvard Kennedy School and Harvard Business School, where he teaches leadership and happiness. He writes the wildly popular "How to Build a Life" column at The Atlantic, hosts the weekly podcast "Office Hours with Arthur Brooks," and has authored 15 books, including two number one New York Times bestsellers: Build the Life You Want with Oprah Winfrey, and From Strength to Strength. His new book, The Meaning of Your Life: Finding Purpose in an Age of Emptiness, releases March 31, 2026. Brooks is one of the world's foremost experts on the science of human happiness.

Dave and Arthur go deep on hemispheric lateralization, the rediscovered neuroscience showing your right brain holds everything that makes life worth living: meaning, mystery, consciousness, and the ineffable experiences that no AI, no nootropic, and no amount of fasting or sleep optimization can manufacture for you. They break down why the depression and anxiety epidemic is really a right-brain deficiency crisis, and why all the supplements, ketosis protocols, and functional medicine hacks in the world won't fix it if you're living entirely in your left hemisphere.

This is a rare episode that bridges hard neuroscience with the deepest questions of human existence. Whether you're deep into anti-aging, neuroplasticity training, or Smarter Not Harder living, this conversation will change how you think about what you're actually optimizing for.

You'll Learn:
Why the mental health crisis is fundamentally a meaning crisis, and what your brain hemispheres have to do with it
How technology, AI, and screen culture are suppressing the right hemisphere and wiring you for anxiety
The six scientifically backed ways to open your right brain and unlock experiences of real meaning
Why self-improvement fails without first understanding the neuroscience of how ideas install in the brain
How suffering, handled correctly, is the single most powerful path to consciousness and purpose
Why romantic love, beauty, and deep conversation are forms of neurological medicine
What Dave's $2.5 million biohacking journey taught him about the limits of optimization
The Buddhist physics of suffering: pain times resistance, and how to lower the resistance instead of the pain


Thank you to our sponsors!
- Danger Coffee | Grab yours at DangerCoffee.com and use code DAVEPOD at checkout for 15% off.
- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.
- Join My Low-Oxalate 30-Day Challenge: daveasprey.com/2026-low-ox-reset
- Calroy | Go to Calroy.com/DAVE for exclusive discounts on Arterosil HP, Vascanox HP and all Calroy products.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Arthur Brooks, Harvard happiness research, meaning of life, hemispheric lateralization, right brain left brain, brain optimization, neuroplasticity, consciousness neuroscience, mental health crisis, depression anxiety solutions, human performance, self-improvement science, longevity mindset, biohacking happiness, Dave Asprey, functional medicine, suffering and purpose, AI limits, meaning and purpose, How to Build a Life

Resources:
• Buy Arthur’s new book “The Meaning Of Your Life” at: https://www.penguinrandomhouse.com/books/724315/the-meaning-of-your-life-by-arthur-c-brooks/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:49 – Introduction
02:09 – Teaching & Learning Science
07:05 – Consciousness & Brain Hemispheres
18:51 – Mental Health & Meaning Crisis
20:08 – 6 Ways to Open the Right Brain
21:44 – Deep Questions & Life's Purpose
27:16 – Romantic Love & Relationships
34:37 – Transcendence & Self
41:18 – Finding Your Calling
49:33 – Beauty
53:41 – Suffering & Meaning
57:20 – Closing
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Your gut microbiome controls your brain chemistry, your stress response, your sleep, your metabolism, and your ability to lose weight, and most people have no idea how broken theirs actually is.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/

In this episode, Host Dave Asprey and microbiome expert Hannah Kleinfeld break down the hidden gut science behind GLP-1 drugs, ADHD, HRV, histamine intolerance, SIBO, and why most probiotics you're taking are probably dead before they even reach your intestines.

Hannah Kleinfeld is the co-founder and COO of Omni-Biotic US, a Yale and Harvard graduate, and a certified health coach whose personal battle with Lyme disease drove her deep into functional medicine and microbiome science. Omni-Biotic is the number one probiotic brand in Europe, used in hospital systems alongside antibiotic treatment, and is now bringing that clinical-grade research to the US market.

Dave and Hannah go deep on the gut-brain axis, the vagus nerve, and how dysbiosis drives everything from brain fog and poor sleep optimization to inflammation, metabolic dysfunction, and compromised mitochondria. They cover how GLP-1 drugs slow gut transit time and trigger secondary dysbiosis, why most capsule probiotics rehydrate in stomach acid and fail, how short-chain fatty acids like butyrate cross the blood-brain barrier to regulate neuroinflammation, and how your gut bacteria directly control your heart rate variability, hormones, libido, and skin. This is biohacking your biology from the inside out, and it goes far deeper than supplements and fasting.

You'll Learn:
Why GLP-1 drugs like Ozempic create secondary dysbiosis and what to do about it
How gut inflammation suppresses HRV, disrupts sleep, and accelerates aging
Why most probiotics rehydrate in stomach acid and never make it to your intestines
The gut-brain connection behind ADHD, brain fog, anxiety, and mood disorders
How dysbiosis sabotages weight loss by skewing Firmicutes to Bacteroidetes ratios
What the vagus nerve has to do with stress resilience and mitochondria health
How to support your microbiome through antibiotics, travel, and SIBO recovery
The histamine problem hiding inside popular probiotic strains
Why the first 1,000 days of a baby's life shape lifelong immunity and HPA axis function
How targeted probiotic formulations are changing functional medicine

Thank you to our sponsors!
Suppgrade Labs | Grab your DAKE and Minerals 101 duo at shopsuppgradelabs.com and use code DAVEPOD for 15% off today
Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference
Fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE
BrainTap | Go to http://braintap.com/dave to get $100 off the BrainTap Power Bundle

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Hannah Kleinfeld, Omni-Biotic, gut microbiome, probiotics that work, GLP-1 gut damage, Ozempic side effects, secondary dysbiosis, gut brain axis, vagusnerve HRV, SIBO treatment, histamine intolerance probiotics, leaky gut inflammation, butyrate blood brain barrier, ADHD gut connection, probiotic capsules vs powder, antibiotic recovery, gut skin axis, microbiome sleep, Firmicutes Bacteroidetes weight loss, functional medicine gut health

Resources:
• Get 20% off your next purchase of OMNi-BiOTiC with code ‘Dave20’ at: https://omnibioticlife.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 - Trailer
01:10 - Intro
03:12 - Kids & Gas: Gut Imbalance in Children
06:42 - Pills vs. Powder Probiotics
07:28 - Omnibiotic Overview & Dave's Story
10:44 - Probiotics & Heart Rate Variability
14:14 - GLP-1 Drugs & the Microbiome
17:24 - Gut & Sleep Quality
19:13 - Probiotics & SIBO
27:47 - Gut Bacteria & ADHD
29:55 - Gut, Libido & Fertility
36:04 - Gut & Unusual Microbiome Facts
43:22 - Histamine Intolerance & Probiotics
51:58 - Kids' Microbiome vs. Adults'
56:10 - Outro
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Try TrueDark (with my discount): https://truedark.com/discount/DAVETUBE

I transformed my vision from 20/80 to 20/15 by stopping the "management of decline" and starting the "restoration of tissue".

The retina is a metabolically hungry tissue that undergoes a nightly repair program, but modern habits like screen use and late-night blue light exposure suppress the melatonin and mitochondrial energy needed for this cleanup.

To reverse this, I use 7 specific daily habits to flip the self-healing switch:
- Mitochondrial Fuel: I use 670 nm red light to directly fuel retinal mitochondria and increase ATP production.
- Pigment Regeneration: I eat blueberries in the evening to accelerate night-vision pigment (rhodopsin) regeneration exactly when the eye needs it.
- Mechanical Rest: I practice "Eye Fasting"—looking at true distance—to release the mechanical tension of constant near-focus.
- Vascular Tone: I use a gentle cold rinse to improve vascular tone and blood flow around the eye.
- Oxidative Stress: I practice grounding to lower systemic oxidative stress and inflammation.
- Corneal Hydration: I use blink training to rehydrate the cornea and stabilize the protective tear film.
- Circadian Anchoring: Finally, I watch the sunset every day to anchor my circadian rhythm, ensuring my eye's repair enzymes activate on time.

Timestamps:
00:00 – Intro
01:05 – The Problem with Traditional Vision Care
02:48 – How Your Eyes Repair Themselves at Night
05:03 – How Modern Life Breaks the Repair Cycle
05:53 – The 7 Habits to Activate Your Eye's Self-Healing Switch
06:07 – Habit 1: Red Light Therapy
07:18 – Habit 2: Blueberries and Rhodopsin
09:22 – Habit 3: Cold Exposure for Blood Flow
11:10 – Habit 4: Grounding to Reduce Oxidative Stress
13:38 – Habit 5: Eye Fasting (Distance Viewing)
15:45 – Habit 6: Deliberate Blinking
17:53 – Habit 7: Sunset Light and Circadian Repair

Thank you to our sponsors!

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week's stories:

*SNL Roasts the MAHA Movement
Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of.
Sources:
-https://www.nbc.com/saturday-night-live
-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/

*Pistachios Are a Stealth Longevity Stack
New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight.
Sources:
-https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/
-https://www.instagram.com/p/DViqesBDOZQ/


*40 Million People Are Using ChatGPT as Their Doctor
Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned.
Sources:
-https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf
-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/
-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/


*Your Microbiome Is a City — and Architecture Matters
New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species.
Sources:
-https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html
-https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html


*Colon Cancer Is Now the Leading Cause of Cancer Death Under 50
This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention.
Sources:
-https://pubmed.ncbi.nlm.nih.gov/41754195/
-https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/


*Measles Is Back — and the Math Is Unambiguous
Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches.
Sources:
-https://www.cdc.gov/measles/cases-outbreaks.html
-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/


This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack.


New episodes every Tuesday, Thursday, Friday, and Sunday.


Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026


Thank you to our sponsors!
- Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap
- The One Device | Use code DAVE for $10 off at theonedevice.com/dave


Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:41 – SNL Roasts the MAHA Movement
03:20 – Pistachios and Longevity
04:37 – AI as Your Health Advisor
06:12 – Gut Biofilms and Microbiome Architecture
07:44 – Colon Cancer in Young People
09:23 – The Measles Comeback
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care.

Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino.

This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology.

You'll Learn:
Why testing TSH alone misses thyroid dysfunction in the vast majority of people
What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3
Why T4-only medications like Synthroid fail and what works better
How low thyroid directly tanks testosterone and libido in both men and women
The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods
How Hashimoto's connects to broader autoimmune risk and what drives it into remission
Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism
The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation
How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes
When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off


Thank you to our sponsors!
TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.
BEYOND Biohacking Conference 2026 | Register with code DAVE300 for $300 off https://beyondconference.com
Our Place | Stop cooking with toxic cookware and upgrade to Our Place today. With a 100-day risk-free trial, plus free shipping and returns, you can experience this game-changing cookware with zero risk. Visit: fromourplace.com/DAVE Use code: DAVE for 10% off sitewide
Puori | Go to Puori.com/DAVE or use code DAVE at checkout to get 32% off your Puori Fish Oil subscription. You save more than $18.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid

Resources:
• Learn More About McCall’s Work At: https://www.modernthyroidclinic.com/
• Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:05 – Intro & Guest Background
02:26 – Dave & McCall's Thyroid Stories
05:26 – How Thyroid Hormones Work
12:51 – Why T4-Only Meds Fall Short
23:05 – Why Thyroid Dysfunction Is So Common
23:59 – Fluoride, Bromine & Environmental Triggers
26:39 – Thyroid & Low Testosterone
27:31 – Optimal Lab Ranges for TSH, T4 & T3
36:58 – Mold, Hashimoto's & Autoimmunity
44:44 – Thyroid, ADHD & Mental Performance
49:38 – Supplements for Thyroid Support
51:52 – Vitamin D & Circadian Rhythms
56:30 – T3 Safety Myths & Medical Misinformation
1:00:16 – Key Takeaways & Where to Get Help
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.