The Human Upgrade: Biohacking for Longevity & Performance

This week's stories:

*SNL Roasts the MAHA Movement
Saturday Night Live took direct aim at RFK-adjacent anti-vaccine culture in a sketch that lampoons raw milk, bull semen, energy healers, and "natural immunity" rhetoric — and it landed with a mainstream audience. Dave breaks down what it means when fringe health narratives become national punchlines, and why being a biohacker means staying precise about what you're actually skeptical of.
Sources:
-https://www.nbc.com/saturday-night-live
-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/

*Pistachios Are a Stealth Longevity Stack
New Cornell-linked research shows pistachios are significantly more bioactive than standard nutrition data suggested — hitting Nrf2, AMPK, and gut barrier pathways simultaneously. This is a whole-food hack hiding in plain sight.
Sources:
-https://www.reddit.com/r/Biohackers/comments/1rvcqiy/cornell_university_reveals_pistachios_are_far/
-https://www.instagram.com/p/DViqesBDOZQ/


*40 Million People Are Using ChatGPT as Their Doctor
Industry estimates put daily ChatGPT health queries at roughly 40 million users — making AI the largest informal primary care interface on the planet. Dave lays out the only safe framework for using these tools without getting burned.
Sources:
-https://www.linkedin.com/pulse/month-healthcare-ai-march-2026-gary-monk-ermcf
-https://www.statnews.com/2026/03/03/fda-breakthrough-designation-generative-ai-chatbot-recovryai/
-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/


*Your Microbiome Is a City — and Architecture Matters
New biofilm research shows that how your gut microbes physically organize themselves may matter as much as which strains you have. The next frontier of microbiome hacking is infrastructure, not species.
Sources:
-https://phys.org/news/2026-01-hidden-microbial-communities-health-space.html
-https://astrobiology.com/2026/03/rethinking-the-microbial-future-of-space-travel.html


*Colon Cancer Is Now the Leading Cause of Cancer Death Under 50
This is no longer a retirement problem. Dave breaks down the four drivers behind the spike — and why your gut health protocols are now frontline cancer prevention.
Sources:
-https://pubmed.ncbi.nlm.nih.gov/41754195/
-https://www.washingtonpost.com/wellness/2026/03/03/muscle-strength-longevity-study/


*Measles Is Back — and the Math Is Unambiguous
Over 1,300 confirmed cases across 31 states in 2026 alone, with the US at risk of losing its measles elimination status for the first time since 2000. Dave addresses the "natural immunity" argument directly — and doesn't pull punches.
Sources:
-https://www.cdc.gov/measles/cases-outbreaks.html
-https://bipartisanpolicy.org/issue-brief/fda-oversight-understanding-the-regulation-of-health-ai-tools/


This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on immune resilience, gut health, microbiome optimization, cancer prevention, and how to use AI tools safely. Host Dave Asprey connects emerging science, cultural shifts, and real epidemiological data into practical frameworks you can use to build a resilient, adaptable health stack.


New episodes every Tuesday, Thursday, Friday, and Sunday.


Keywords: MAHA movement biohacking, SNL vaccine sketch, RFK health satire, pistachios polyphenols longevity, pistachio Nrf2 AMPK, ChatGPT health advice AI, AI primary care risks, gut microbiome biofilm architecture, colon cancer under 50, colorectal cancer young adults, colon cancer prevention diet, measles outbreak 2026, measles elimination status, natural immunity measles risk, immune amnesia measles, biohacking news, longevity research 2026


Thank you to our sponsors!
- Dave Asprey's 2026 Clean Nicotine Roadmap | Enroll for free at: daveasprey.com/2026-clean-nicotine-roadmap
- The One Device | Use code DAVE for $10 off at theonedevice.com/dave


Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:41 – SNL Roasts the MAHA Movement
03:20 – Pistachios and Longevity
04:37 – AI as Your Health Advisor
06:12 – Gut Biofilms and Microbiome Architecture
07:44 – Colon Cancer in Young People
09:23 – The Measles Comeback
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Your thyroid controls your energy, your metabolism, your testosterone, your mood, and your ability to think clearly. Most doctors are testing it wrong and treating it wrong, and this episode tells you exactly what to do instead.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with McCall McPherson, a physician associate, TEDx speaker, and founder of Modern Thyroid Clinic, Modern Weight Loss, and the advocacy platform Thyroid Nation. McPherson has been honored on the 2024 and 2025 Inc. 5000 lists and named a 2025 Top 500 Inc. Female Founder. She hosts the Modern Thyroid and Wellness podcast and built her entire practice around thyroid care after being failed by conventional medicine while managing her own hypothyroidism. She treats patients nationwide via telemedicine and has become one of the most trusted voices in functional medicine thyroid care.

Dave and McCall expose why standard TSH-only testing catches just 1 to 2 percent of actual thyroid variation, why the medication most doctors prescribe (Synthroid/levothyroxine) fails a massive percentage of patients, and why T3 is the active hormone that mainstream medicine has been trained to fear without good reason. They also get into how fluoride in tap water, bromine in American wheat, mold exposure, dairy, gluten, and oxalates directly suppress thyroid function and drive autoimmunity. If you want to optimize your metabolism, protect your mitochondria, support brain optimization, and stop leaving your longevity on the table, thyroid is the first domino.

This is essential listening for anyone serious about biohacking, human performance, anti-aging, functional medicine, supplements, sleep optimization, and using smarter not harder strategies to take control of your biology.

You'll Learn:
Why testing TSH alone misses thyroid dysfunction in the vast majority of people
What a full thyroid panel actually includes and the optimal ranges for T4, T3, and reverse T3
Why T4-only medications like Synthroid fail and what works better
How low thyroid directly tanks testosterone and libido in both men and women
The environmental triggers destroying your thyroid, including fluoride, bromine, mold, and inflammatory foods
How Hashimoto's connects to broader autoimmune risk and what drives it into remission
Why kids are being misdiagnosed with ADHD when the real issue is hypothyroidism
The supplements and cofactors (selenium, zinc, magnesium, ashwagandha, tyrosine) that support thyroid activation
How thyroid optimization connects to metabolism, dementia prevention, cardiovascular health, and economic outcomes
When to use T3 only vs. a T3/T4 combination, and how to know if your dose is off


Thank you to our sponsors!
TRU KAVA | Head to trukava.com and use code DAVE10 for 10% off.
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: McCall McPherson, Modern Thyroid Clinic, thyroid testing wrong, full thyroid panel, free T3, reverse T3, Synthroid failure, T3 vs T4, Hashimoto's remission, fluoride suppresses thyroid, thyroid low testosterone, thyroid ADHD, thyroid depression, hypothyroidism misdiagnosis, thyroid and metabolism, thyroid hair loss, functional medicine thyroid

Resources:
• Learn More About McCall’s Work At: https://www.modernthyroidclinic.com/
• Get McCall's Thyroid Guide: https://gift.modernthyroidclinic.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:05 – Intro & Guest Background
02:26 – Dave & McCall's Thyroid Stories
05:26 – How Thyroid Hormones Work
12:51 – Why T4-Only Meds Fall Short
23:05 – Why Thyroid Dysfunction Is So Common
23:59 – Fluoride, Bromine & Environmental Triggers
26:39 – Thyroid & Low Testosterone
27:31 – Optimal Lab Ranges for TSH, T4 & T3
36:58 – Mold, Hashimoto's & Autoimmunity
44:44 – Thyroid, ADHD & Mental Performance
49:38 – Supplements for Thyroid Support
51:52 – Vitamin D & Circadian Rhythms
56:30 – T3 Safety Myths & Medical Misinformation
1:00:16 – Key Takeaways & Where to Get Help
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What if a glowing pyramid sitting in your living room could restructure your biology, compress decades of meditation into minutes, and shift your brain into an altered state without drugs, breathwork, or effort? This episode reveals the science and experience behind one of the most unusual biohacking technologies Host Dave Asprey has ever encountered.

-Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR
-Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/

Jason Shurka is an author, philanthropist, and founder of Unified Healing, a global network spanning 55 countries and hundreds of wellness centers worldwide. He has written five books on health, consciousness, and human performance, and serves as the driving force behind The Light System, a technology now joined with the Gaia Network. Shurka has spent years documenting firsthand results from people around the world, making him one of the most credible independent voices on emerging light-based healing technologies.

Dave Asprey and Jason Shurka break down exactly how The Light System uses full spectrum biophotonic light and encoded affirmations to create a coherent energy field that the body synchronizes with at a cellular level. They explore how this technology targets the molecular structure of water in your body, increases cellular electrical conductivity by up to 80 percent in under an hour, and creates the conditions your mitochondria need to produce more energy, accelerate recovery, and trigger deep self healing.

You will learn why your body is already a light based organism, how biophotons drive biological communication at the cellular level, and why the geometry of a pyramid amplifies these effects in ways that flat screen technology cannot replicate. They also dig into the nature of consciousness, the ego as a biological operating system, and why the most powerful biohacking interventions are often the ones that work below the threshold of conscious awareness.

You will Learn:
Why cellular electrical conductivity increases by 80 percent after one hour of exposure to The Light System
How encoded light affirmations restructure the molecular formation of water in your body without conscious effort
What biophotons are and why your mitochondria, gut bacteria, and DNA are already producing and receiving them
How full spectrum visible light maps directly onto the body's energy centers and organ systems
Why the metamatrix font used in The Light System produces stronger biological effects than standard text
How this technology was invented by a programmer combining transcendental meditation with software development
What happens to your brain state when you stare at encoded light and why it resembles deep meditation without the effort
How geometry, specifically the pyramid shape, amplifies photonic output and room coverage
Why altered states accessed through light may be one of the most underexplored frontiers in brain optimization and neuroplasticity
How to use The Light System for sleep optimization, pain relief, and cellular recovery

Thank you to our sponsors!
Pre-order Arthur Brook's new book today at themeaningofyourlife.com. You can also see Arthur speak live at the 2026 Beyond Biohacking Conference
Go to timeline.com/dave and save 20% with code DAVE20
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: The Light System, Jason Shurka, Unified Healing, Robert Religa, biophotons, metamatrix font, encoded affirmations, water structuring, electrical impedance spectroscopy, cellular conductivity, full spectrum visible light, pyramid geometry, transcendental meditation, Masaru Emoto, water crystals, morphogenic field, quantum biology, Gaia Network, Dr. Glenn Ryan, biofield, meditation technology, hair regrowth, autism light therapy, Dave Asprey, biohacking, mitochondria, smarter not harder

Resources:
• Get $250 off from The Light System by using code ‘daveasprey’ at: https://www.thelightsystems.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:20 – Intro
03:50 – What Is The Light System?
05:39 – Encoded Affirmations & Metamatrix Font
08:10 – Dr. Emoto's Water Experiment
10:13 – Light Restructures Body Water
13:09 – Skeptics & Quantum Science
18:43 – 80% Conductivity Study
20:45 – The Body Heals Itself
23:40 – Ego & Certainty
26:37 – Real-World Testimonials
36:43 – Reversing Asperger's
38:24 – Light System & Autism
41:14 – Why Not a Phone?
43:39 – Biophotons Are Real
56:37 – Color Settings & Programs
58:35 – Wrap-Up & Discount Code
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Is aging an inevitable decline, or just a "repair backlog" your body hasn't cleared yet?. In this episode, Dave breaks down the 2016 Nobel Prize-winning science of autophagy—the body's internal recycling system discovered by Dr. Yoshinori Ohsumi.

Most people are stuck in a state of "biological debt," where cellular junk piles up like trash in a factory, leading to brain fog, fatigue, and chronic inflammation. Standard 16-hour fasts aren't enough to reach the deep-cleaning phase. You will learn the exact 3-day protocol to trigger a "Deep Reset," where ketones peak, inflammation falls, and stem cells wake up to rebuild your immune system from scratch.

Join my FREE Fasting Challenge: https://daveasprey.com/fast-this-way-challenge/

Timestamps:
00:00 - The Anti-Aging Switch
01:30 - Chronological vs. Biological Age
02:32 - How Aging Works at the Cellular Level
04:58 - 43 Ways to Upgrade Your Mitochondria
07:37 - What Is Autophagy
09:17 - The Stages of Fasting
10:46 - What Happens During a 3-Day Fast
13:04 - How to Fast Correctly
14:42 - Breaking the Fast
15:58 - The Power of Subtraction

Thank you to our sponsors!
-KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off
-Join My Low-Oxalate 30-Day Challenge: https://daveasprey.com/2026-low-ox-reset/

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Danger Coffee: https://dangercoffee.com/DAVE15
Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

This week’s stories:

Smartphone App Catches What Sleep Trackers Miss
A 2026 trial found that suvorexant, a popular prescription sleep drug, improves sleep quality scores — but worsens morning alertness and cognitive function while improving afternoon and evening performance. The study used a smartphone app to pulse users throughout the day, revealing a split-time-of-day signal that traditional sleep scales miss entirely. Optimizing your sleep dashboard and optimizing your waking performance are not the same thing.
Sources:
https://jamanetwork.com/journals/jama/fullarticle/suvorexant-ema-trial-2026
https://www.ncbi.nlm.nih.gov/pmc/articles/suvorexant-daytime-performance

Bats Are Breaking the Telomere Model
A 2026 bioRxiv preprint on the tropical bat species Molossus molossus found that these animals live unusually long lives with almost no telomere shortening — challenging the assumption that telomere erosion is a universal driver of mammalian aging. Instead, the bats maintain genome integrity through superior DNA repair and oxidative stress management driven by the metabolic demands of flight. Telomere length may be a symptom, not the cause — and the longevity industry has been measuring the wrong thing.
Sources:
https://www.biorxiv.org/content/molossus-molossus-telomere-longevity-2026
https://www.nature.com/articles/telomere-bat-aging-2026

The Fenugreek Hack That Cuts Glucose Spikes by Up to 20%
Soaking fenugreek seeds overnight and consuming them before meals has been shown across multiple small human trials to reduce fasting glucose and post-meal glucose spikes by 5 to 20 percent. The mechanism is dual — soluble galactomannan fibers slow carbohydrate absorption while bioactive compounds improve insulin receptor sensitivity in muscle and liver. It's a cheap, food-grade, CGM-trackable lever that most people have never tried.
Sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/fenugreek-glucose-clinical-review
https://pubmed.ncbi.nlm.nih.gov/fenugreek-insulin-sensitivity-trial

The First Longevity Supplement to Move Vascular Age Like Exercise
A randomized, double-blind, placebo-controlled trial out of the University of Surrey found that a multi-ingredient longevity stack targeting NAD metabolism, glycation control, and mitochondrial function improved three independent vascular aging markers simultaneously in healthy adults over 40. Arterial stiffness improved by 1.18 meters per second — equivalent to reversing roughly a decade of age-related decline. Blood pressure dropped 6.1 millimeters of mercury, outperforming aerobic exercise, HIIT, the DASH diet, omega-3s, and magnesium in head-to-head comparisons.
Sources:
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=6241278
https://clinicaltrials.gov/study/NCT06145087
https://novoslabs.com/blog/supplements/novos-core-clinical-trial-results-longevity-supplement
https://www.medicalnewstoday.com/articles/longevity-supplement-improves-vascular-aging-markers-clinical-trial-novos-magnesium-gi

Carbon Monoxide Exposure Is Up 50% in 2026 — And Most People Won't Know Until It's Too Late
Maryland state data reported by CBS News shows emergency room and urgent care visits for carbon monoxide exposure jumped from 167 cases in 2025 to 251 so far in 2026 — a nearly 50 percent increase. CO binds to hemoglobin more tightly than oxygen, quietly starving your brain, heart, and muscles while producing symptoms that mimic fatigue, brain fog, and the flu. The CDC estimates more than 400 Americans die from unintentional CO poisoning every year — and most of them never saw it coming.
Sources:
https://kffhealthnews.org/morning-briefing/friday-march-6-2026
https://www.cdc.gov/niosh/topics/co/default.html
https://www.cbsnews.com/news/carbon-monoxide-exposure-maryland-spike-2026


Fat Plus Carbs Around Training May Actually Be the Metabolic Move
A 2026 study found that combining fat with a carbohydrate-rich period during or around exercise improves insulin sensitivity and fat oxidation in the recovery phase — directly challenging the long-held "never stack fat and carbs" rule. The mechanism appears to be a mixed-fuel training effect: the liver and muscle learn to manage glucose and fat concurrently when both are present during high metabolic demand. Context changes the calculus, and the workout itself may be the variable that flips the equation.
Sources:
https://www.ncbi.nlm.nih.gov/pmc/articles/fat-carb-exercise-metabolism-2026
https://pubmed.ncbi.nlm.nih.gov/fat-carbohydrate-insulin-sensitivity-training


All source links are provided for direct access to the original reporting and research.

This episode is designed for biohackers, longevity seekers, and high-performance listeners who want mechanism-level clarity on circadian biology, neurodegeneration signals, cognitive training, caffeine strategy, and supplement regulation. Host Dave Asprey connects emerging science, behavioral data, and policy shifts into practical frameworks you can use to build a resilient, adaptable health stack.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: sleep medication daytime performance, suvorexant alertness, sleep score vs performance, telomere aging myth, bat longevity telomeres, DNA repair aging, fenugreek blood glucose, fenugreek insulin sensitivity, CGM glucose hack, longevity supplement clinical trial, vascular aging markers, arterial stiffness reversal, pulse wave velocity supplement, carbon monoxide poisoning 2026, CO detector home safety, environmental toxin biohacking, fat and carbs exercise, macronutrient timing training, insulin sensitivity workout, metabolic flexibility training, biohacking news, longevity research 2026

Thank you to our sponsors!
- The One Device | Use code DAVE for $10 off at theonedevice.com/dave
- Screenfit | Get your at-home eye training program for 40% off using code DAVE at https://www.screenfit.com/dave.

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Intro
00:20 – Trailer
00:57 - Story #1: Sleep Meds & Morning Performance
02:42 - Story #2: Bats & the Telomere Model
04:33 - Story #3: Fenugreek & Glucose Spikes
06:00 - Story #4: Multi-Ingredient Longevity Stack Trial
07:51 - Story #5: Carbon Monoxide: The Silent Threat
09:45 - Story #6: Fat + Carbs Around Exercise
11:25 - Weekly Roundup
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.