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Tonny Media
Lang zal je leven
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  • Zweet je jezelf oud? Dit kan de sauna doen voor dementie
    Regelmatig in de sauna? Dan leef je misschien wel langer. In deze aflevering duiken Tom en Alexander in het zweet om te ontdekken of sauneren de kans op dementie én hartproblemen echt verkleint.Tom test vier dagen lang verschillende sauna’s, van Finse hitte tot infrarood licht, terwijl dokter Alexander de claims ontleedt: 🔥 Sauna (infrarood) helpt met spierherstel💧 Afvallen en detoxen door zweten🧠 Sauna verkleint de kans op dementie en Alzheimer❤️ Sauna is goed voor je hartgezondheid Het antwoord hoor je in aflevering 4 van Lang Zal Je Leven. 🎧 Geproduceerd door Tonny Media👉 Volg ons op Instagram, TikTok en YouTube🥼 Alle onderzoeken die in deze aflevering worden besproken vind je hier: Laukkanen T, Kunutsor SK, Zaccardi F, Lee E, Willeit P, Khan H, Laukkanen JA. Acute effects of sauna bathing on cardiovascular function. J Hum Hypertens. 2018 Feb;32(2):129-138. doi: 10.1038/s41371-017-0008-z. Epub 2017 Dec 21. PMID: 29269746. Laukkanen T, Khan H, Zaccardi F, Laukkanen JA. Association between sauna bathing and fatal cardiovascular and all-cause mortality events. JAMA Intern Med. 2015 Apr;175(4):542-8. doi: 10.1001/jamainternmed.2014.8187. PMID: 25705824. Laukkanen T, Kunutsor S, Kauhanen J, Laukkanen JA. Sauna bathing is inversely associated with dementia and Alzheimer's disease in middle-aged Finnish men. Age Ageing. 2017 Mar 1;46(2):245-249. doi: 10.1093/ageing/afw212. PMID: 27932366. Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna bathing is associated with reduced cardiovascular mortality and improves risk prediction in men and women: a prospective cohort study. BMC Med. 2018 Nov 29;16(1):219. doi: 10.1186/s12916-018-1198-0. PMID: 30486813; PMCID: PMC6262976. Kunutsor SK, Khan H, Zaccardi F, Laukkanen T, Willeit P, Laukkanen JA. Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study. Neurology. 2018 May 29;90(22):e1937-e1944. doi: 10.1212/WNL.0000000000005606. Epub 2018 May 2. PMID: 29720543. Imamura, M, Biro, S, Kihara, T. et al. Repeated thermal therapy improves impaired vascular endothelial function in patients with coronary risk factors. JACC. 2001 Oct, 38 (4) 1083–1088. https://doi.org/10.1016/S0735-1097(01)01467-X Lee E, Laukkanen T, Kunutsor SK, Khan H, Willeit P, Zaccardi F, Laukkanen JA. Sauna exposure leads to improved arterial compliance: Findings from a non-randomised experimental study. Eur J Prev Cardiol. 2018 Jan;25(2):130-138. doi: 10.1177/2047487317737629. Epub 2017 Oct 19. PMID: 29048215. Kunutsor, S. K., Khan, H., Laukkanen, T., & Laukkanen, J. A. (2017). Joint associations of sauna bathing and cardiorespiratory fitness on cardiovascular and all-cause mortality risk: a long-term prospective cohort study. Annals of Medicine, 50(2), 139–146. https://doi.org/10.1080/07853890.2017.1387927 Knekt P, Järvinen R, Rissanen H, Heliövaara M, Aromaa A. Does sauna bathing protect against dementia? Prev Med Rep. 2020 Oct 2;20:101221. doi: 10.1016/j.pmedr.2020.101221. PMID: 33088678; PMCID: PMC7560162. Kunutsor SK, Jae SY, Laukkanen JA. Frequent sauna bathing offsets the increased risk of death due to low socioeconomic status: A prospective cohort study of middle-aged and older men. Exp Gerontol. 2022 Oct 1;167:111906. doi: 10.1016/j.exger.2022.111906. Epub 2022 Jul 28. PMID: 35908583. Scoon GS, Hopkins WG, Mayhew S, Cotter JD. Effect of post-exercise sauna bathing on the endurance performance of competitive male runners. J Sci Med Sport. 2007 Aug;10(4):259-62. doi: 10.1016/j.jsams.2006.06.009. Epub 2006 Jul 31. PMID: 16877041. Ahokas EK, Ihalainen JK, Hanstock HG, Savolainen E, Kyröläinen H. A post-exercise infrared sauna session improves recovery of neuromuscular performance and muscle soreness after resistance exercise training. Biol Sport. 2023 Jul;40(3):681-689. doi: 10.5114/biolsport.2023.119289. Epub 2022 Sep 15. PMID: 37398966; PMCID: PMC10286597. Garrett AT, Goosens NG, Rehrer NJ, Patterson MJ, Harrison J, Sammut I, Cotter JD. Short-term heat acclimation is effective and may be enhanced rather than impaired by dehydration. Am J Hum Biol. 2014 May-Jun;26(3):311-20. doi: 10.1002/ajhb.22509. Epub 2014 Jan 28. PMID: 24469986. Pilch W, Pokora I, Szyguła Z, Pałka T, Pilch P, Cisoń T, Malik L, Wiecha S. Effect of a single finnish sauna session on white blood cell profile and cortisol levels in athletes and non-athletes. J Hum Kinet. 2013 Dec 31;39:127-35. doi: 10.2478/hukin-2013-0075. PMID: 24511348; PMCID: PMC3916915. Kissling LS, Akerman AP, Campbell HA, Prout JR, Gibbons TD, Thomas KN, Cotter JD. A crossover control study of three methods of heat acclimation on the magnitude and kinetics of adaptation. Exp Physiol. 2022 Apr;107(4):337-349. doi: 10.1113/EP089993. Epub 2022 Mar 16. PMID: 34957632. Hedley AM, Climstein M, Hansen R. The effects of acute heat exposure on muscular strength, muscular endurance, and muscular power in the euhydrated athlete. J Strength Cond Res. 2002 Aug;16(3):353-8. PMID: 12173948. Kirby NV, Lucas SJE, Cable TG, Armstrong OJ, Weaver SR, Lucas RAI. Sex differences in adaptation to intermittent post-exercise sauna bathing in trained middle-distance runners. Sports Med Open. 2021 Jul 23;7(1):51. doi: 10.1186/s40798-021-00342-6. PMID: 34297227; PMCID: PMC8302716. Hayasaka S, Nakamura Y, Kajii E, Ide M, Shibata Y, Noda T, Murata C, Nagata K, Ojima T. Effects of charcoal kiln saunas (Jjimjilbang) on psychological states. Complement Ther Clin Pract. 2008 May;14(2):143-8. doi: 10.1016/j.ctcp.2007.12.004. Epub 2008 Mar 4. PMID: 18396259. Naumann J, Grebe J, Kaifel S, Weinert T, Sadaghiani C, Huber R. Effects of hyperthermic baths on depression, sleep and heart rate variability in patients with depressive disorder: a randomized clinical pilot trial. BMC Complement Altern Med. 2017 Mar 28;17(1):172. doi: 10.1186/s12906-017-1676-5. PMID: 28351399; PMCID: PMC5371197. Laukkanen T, Laukkanen JA, Kunutsor SK. Sauna Bathing and Risk of Psychotic Disorders: A Prospective Cohort Study. Med Princ Pract. 2018;27(6):562-569. doi: 10.1159/000493392. Epub 2018 Sep 2. PMID: 30173212; PMCID: PMC6422146. https://journals.sagepub.com/doi/10.1177/089198879600900203 Hussain JN, Greaves RF, Cohen MM. A hot topic for health: Results of the Global Sauna Survey. Complement Ther Med. 2019 Jun;44:223-234. doi: 10.1016/j.ctim.2019.03.012. Epub 2019 Apr 24. PMID: 31126560. See omnystudio.com/listener for privacy information.
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  • Hoeveel koffie is te veel?
    Iedereen drinkt het, maar bijna niemand weet: hoeveel koppen koffie zijn nog gezond?Tom test het op de harde manier, van een overdosis aan koffie naar cold turkey helemaal geen koffie en dokter Alexander legt uit wat de wetenschap zegt over de ideale dosis. In deze aflevering bespreken ze: Helpt koffie écht tegen vermoeidheid? Hoeveel koppen koffie zijn goed voor je, en waarom is de timing belangrijk? Is koffie goed voor afvallen en je hartgezondheid? Droogt het je uit, en klopt het dat het je stresshormoon omhoog jaagt? Tom test het in de praktijk, Alexander checkt de wetenschap. 🗣️ Waar zoek jij naar steun? Als grootste online therapieplatform ter wereld biedt Betterhelp toegang tot deskundige therapeuten. Luisteraars van deze podcast krijgen 10% korting op de eerste maand via www.betterhelp.com/langzaljeleven 🎧 Geproduceerd door Tonny Media👉 Volg ons op Instagram, TikTok en YouTubeOnderzoeken die Alexander heeft gebruik voor deze aflevering: Blanchard J, Sawers SJ. The absolute bioavailability of caffeine in man. Eur J Clin Pharmacol. 1983;24(1):93-98. doi:10.1007/bf00613933 Huang ZL, Qu WM, Eguchi N, et al. Adenosine A2A, but not A1, receptors mediate the arousal effect of caffeine. Nat Neurosci. 2005;8(7):858-859. doi:10.1038/nn1491 Reichert CF, Deboer T, Landolt HP. Adenosine, caffeine, and sleep-wake regulation: state of the science and perspectives. J Sleep Res. 2022;31(4):e13597. doi:10.1111/jsr.13597 Alasmari F. Caffeine induces neurobehavioral effects through modulating neurotransmitters. Saudi Pharm J. 2020;28(4):445-451. doi:10.1016/j.jsps.2020.02.005 Tian DD, Natesan S, White JR , Jr, Paine MF. Effects of common CYP1A2 genotypes and other key factors on intraindividual variation in the caffeine metabolic ratio: An exploratory analysis. Clin Transl Sci. 2019;12(1):39-46. doi:10.1111/cts.12598 Faber MS, Jetter A, Fuhr U. Assessment of CYP1A2 activity in clinical practice: why, how, and when? Basic Clin Pharmacol Toxicol. 2005;97(3):125-134. doi:10.1111/j.1742-7843.2005.pto_973160.x Low JJL, Tan BJW, Yi LX, Zhou ZD, Tan EK. Genetic susceptibility to caffeine intake and metabolism: a systematic review. J Transl Med. 2024;22(1):961. doi:10.1186/s12967-024-05737-z Matthaei J, Tzvetkov MV, Strube J, et al. Heritability of caffeine metabolism: Environmental effects masking genetic effects on CYP1A2 activity but not on NAT2. Clin Pharmacol Ther. 2016;100(6):606-616. doi:10.1002/cpt.444 Parsons WD, Neims AH. Effect of smoking on caffeine clearance. Clin Pharmacol Ther. 1978;24(1):40-45. doi:10.1002/cpt197824140 Gunes A, Ozbey G, Vural EH, et al. Influence of genetic polymorphisms, smoking, gender and age on CYP1A2 activity in a Turkish population. Pharmacogenomics. 2009;10(5):769-778. doi:10.2217/pgs.09.22 Kall MA, Clausen J. Dietary effect on mixed function P450 1A2 activity assayed by estimation of caffeine metabolism in man. Hum Exp Toxicol. 1995;14(10):801-807. doi:10.1177/096032719501401004 Vistisen K, Poulsen HE, Loft S. Foreign compound metabolism capacity in man measured from metabolites of dietary caffeine. Carcinogenesis. 1992;13(9):1561-1568. doi:10.1093/carcin/13.9.1561 Abernethy DR, Todd EL. Impairment of caffeine clearance by chronic use of low-dose oestrogen-containing oral contraceptives. Eur J Clin Pharmacol. 1985;28(4):425-428. doi:10.1007/bf00544361 Gunes A, Dahl ML. Variation in CYP1A2 activity and its clinical implications: influence of environmental factors and genetic polymorphisms. Pharmacogenomics. 2008;9(5):625-637. doi:10.2217/14622416.9.5.625 Lane JD, Steege JF, Rupp SL, Kuhn CM. Menstrual cycle effects on caffeine elimination in the human female. Eur J Clin Pharmacol. 1992;43(5):543-546. doi:10.1007/bf02285099 Tracy TS, Venkataramanan R, Glover DD, Caritis SN, National Institute for Child Health and Human Development Network of Maternal-Fetal-Medicine Units. 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Effects of a single, oral 60 mg caffeine dose on attention in healthy adult subjects. J Psychopharmacol. 2017;31(2):222-232. doi:10.1177/0269881116668593 Liu C, Wang L, Zhang C, et al. Caffeine intake and anxiety: a meta-analysis. Front Psychol. 2024;15:1270246. doi:10.3389/fpsyg.2024.1270246 Březinová V. Effect of caffeine on sleep: EEG study in late middle age people. Br J Clin Pharmacol. 1974;1(3):203-208. doi:10.1111/j.1365-2125.1974.tb00237.x Gardiner CL, Weakley J, Burke LM, et al. Dose and timing effects of caffeine on subsequent sleep: A randomised clinical crossover trial. Sleep. Published online October 8, 2024. doi:10.1093/sleep/zsae230 Quiquempoix M, Drogou C, Erblang M, et al. Relationship between habitual caffeine consumption, attentional performance, and individual alpha frequency during total sleep deprivation. Int J Environ Res Public Health. 2023;20(6). doi:10.3390/ijerph20064971 Glaister M, Gissane C. 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Effect of caffeine ingestion on muscular strength and endurance: a meta-analysis. Med Sci Sports Exerc. 2010;42(7):1375-1387. doi:10.1249/MSS.0b013e3181cabbd8 Grgic J, Trexler ET, Lazinica B, Pedisic Z. Effects of caffeine intake on muscle strength and power: a systematic review and meta-analysis. J Int Soc Sports Nutr. 2018;15:11. doi:10.1186/s12970-018-0216-0 Grgic J, Grgic I, Pickering C, Schoenfeld BJ, Bishop DJ, Pedisic Z. Wake up and smell the coffee: caffeine supplementation and exercise performance-an umbrella review of 21 published meta-analyses. Br J Sports Med. 2020;54(11):681-688. doi:10.1136/bjsports-2018-100278 Ferreira TT, da Silva JVF, Bueno NB. Effects of caffeine supplementation on muscle endurance, maximum strength, and perceived exertion in adults submitted to strength training: a systematic review and meta-analyses. Crit Rev Food Sci Nutr. 2021;61(15):2587-2600. doi:10.1080/10408398.2020.1781051 Lopes-Silva JP, Choo HC, Franchini E, Abbiss CR. Isolated ingestion of caffeine and sodium bicarbonate on repeated sprint performance: A systematic review and meta-analysis. J Sci Med Sport. 2019;22(8):962-972. doi:10.1016/j.jsams.2019.03.007 Collegiate and Professional Sports Dietitians Association. Caffeine and Athletic Performance. National Collegiate Athletic Association; 2014. Koot P, Deurenberg P. Comparison of changes in energy expenditure and body temperatures after caffeine consumption. Ann Nutr Metab. 1995;39(3):135-142. doi:10.1159/000177854 Acheson KJ, Zahorska-Markiewicz B, Pittet P, Anantharaman K, Jéquier E. Caffeine and coffee: their influence on metabolic rate and substrate utilization in normal weight and obese individuals. Am J Clin Nutr. 1980;33(5):989-997. doi:10.1093/ajcn/33.5.989 Acheson KJ, Gremaud G, Meirim I, et al. Metabolic effects of caffeine in humans: lipid oxidation or futile cycling? Am J Clin Nutr. 2004;79(1):40-46. doi:10.1093/ajcn/79.1.40 Gavrieli A, Karfopoulou E, Kardatou E, et al. Effect of different amounts of coffee on dietary intake and appetite of normal-weight and overweight/obese individuals. Obesity (Silver Spring). 2013;21(6):1127-1132. doi:10.1002/oby.20190 Tabrizi R, Saneei P, Lankarani KB, et al. The effects of caffeine intake on weight loss: a systematic review and dos-response meta-analysis of randomized controlled trials. Crit Rev Food Sci Nutr. 2019;59(16):2688-2696. doi:10.1080/10408398.2018.1507996 Phung OJ, Baker WL, Matthews LJ, Lanosa M, Thorne A, Coleman CI. Effect of green tea catechins with or without caffeine on anthropometric measures: a systematic review and meta-analysis. Am J Clin Nutr. 2010;91(1):73-81. doi:10.3945/ajcn.2009.28157 Hursel R, Westerterp-Plantenga MS. Green tea catechin plus caffeine supplementation to a high-protein diet has no additional effect on body weight maintenance after weight loss. Am J Clin Nutr. 2009;89(3):822-830. doi:10.3945/ajcn.2008.27043 Dulloo AG, Geissler CA, Horton T, Collins A, Miller DS. Normal caffeine consumption: influence on thermogenesis and daily energy expenditure in lean and postobese human volunteers. Am J Clin Nutr. 1989;49(1):44-50. doi:10.1093/ajcn/49.1.44 Panchal SK, Wong WY, Kauter K, Ward LC, Brown L. Caffeine attenuates metabolic syndrome in diet-induced obese rats. Nutrition. 2012;28(10):1055-1062. doi:10.1016/j.nut.2012.02.013 Martins BC, Soares AC, Martins FF, et al. Coffee consumption prevents obesity-related comorbidities and attenuates brown adipose tissue whitening in high-fat diet-fed mice. J Nutr Biochem. 2023;117(109336):109336. doi:10.1016/j.jnutbio.2023.109336 Whitehead N, White H. Systematic review of randomised controlled trials of the effects of caffeine or caffeinated drinks on blood glucose concentrations and insulin sensitivity in people with diabetes mellitus. J Hum Nutr Diet. 2013;26(2):111-125. doi:10.1111/jhn.12033 Shi X, Xue W, Liang S, Zhao J, Zhang X. Acute caffeine ingestion reduces insulin sensitivity in healthy subjects: a systematic review and meta-analysis. Nutr J. 2016;15(1):103. doi:10.1186/s12937-016-0220-7 van Dam RM, Pasman WJ, Verhoef P. Effects of coffee consumption on fasting blood glucose and insulin concentrations: randomized controlled trials in healthy volunteers. Diabetes Care. 2004;27(12):2990-2992. doi:10.2337/diacare.27.12.2990 Moon SM, Joo MJ, Lee YS, Kim MG. Effects of coffee consumption on insulin resistance and sensitivity: A meta-analysis. Nutrients. 2021;13(11):3976. doi:10.3390/nu13113976 Jiang X, Zhang D, Jiang W. Coffee and caffeine intake and incidence of type 2 diabetes mellitus: a meta-analysis of prospective studies. Eur J Nutr. 2014;53(1):25-38. doi:10.1007/s00394-013-0603-x Mirmiran P, Carlström M, Bahadoran Z, Azizi F. Long-term effects of coffee and caffeine intake on the risk of pre-diabetes and type 2 diabetes: Findings from a population with low coffee consumption. Nutr Metab Cardiovasc Dis. 2018;28(12):1261-1266. doi:10.1016/j.numecd.2018.09.001 Alshahrani SH, Atia YA, Badir RA, et al. Dietary caffeine intake is associated with favorable metabolic profile among apparently healthy overweight and obese individuals. BMC Endocr Disord. 2023;23(1):227. doi:10.1186/s12902-023-01477-1 Guarino MP, Ribeiro MJ, Sacramento JF, Conde SV. Chronic caffeine intake reverses age-induced insulin resistance in the rat: effect on skeletal muscle Glut4 transporters and AMPK activity. Age (Dordr). 2013;35(5):1755-1765. doi:10.1007/s11357-012-9475-x Echeverri D, Montes FR, Cabrera M, Galán A, Prieto A. Caffeine’s vascular mechanisms of action. Int J Vasc Med. 2010;2010:834060. doi:10.1155/2010/834060 Zuchinali P, Souza GC, Pimentel M, et al. Short-term effects of high-dose caffeine on cardiac arrhythmias in patients with heart failure: A randomized clinical trial. JAMA Intern Med. 2016;176(12):1752-1759. doi:10.1001/jamainternmed.2016.6374 Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J. Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies. Heart. 2013;99(19):1383-1389. doi:10.1136/heartjnl-2013-303950 Al-Fadhel JA, Al-Sharidi EM, Alashjaee AA, et al. Does excessive caffeine intake increase the risk of atrial fibrillation? A systematic review and meta-analysis of 1176579 subjects. Journal of Advanced Trends in Medical Research. 2024;1(3):870-875. doi:10.4103/atmr.atmr_165_24 Mattioli AV, Farinetti A, Miloro C, Pedrazzi P, Mattioli G. Influence of coffee and caffeine consumption on atrial fibrillation in hypertensive patients. Nutr Metab Cardiovasc Dis. 2011;21(6):412-417. doi:10.1016/j.numecd.2009.11.003 Ding M, Bhupathiraju SN, Satija A, van Dam RM, Hu FB. Long-term coffee consumption and risk of cardiovascular disease: a systematic review and a dose-response meta-analysis of prospective cohort studies. Circulation. 2014;129(6):643-659. doi:10.1161/CIRCULATIONAHA.113.005925 Rodríguez-Artalejo F, López-García E. Coffee consumption and cardiovascular disease: A condensed review of epidemiological evidence and mechanisms. J Agric Food Chem. 2018;66(21):5257-5263. doi:10.1021/acs.jafc.7b04506 Mesas AE, Leon-Muñoz LM, Rodriguez-Artalejo F, Lopez-Garcia E. The effect of coffee on blood pressure and cardiovascular disease in hypertensive individuals: a systematic review and meta-analysis. Am J Clin Nutr. 2011;94(4):1113-1126. doi:10.3945/ajcn.111.016667 Lebeau PF, Byun JH, Platko K, et al. Caffeine blocks SREBP2-induced hepatic PCSK9 expression to enhance LDLR-mediated cholesterol clearance. Nat Commun. 2022;13(1):770. doi:10.1038/s41467-022-28240-9 Superko HR, Bortz W Jr, Williams PT, Albers JJ, Wood PD. 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Association of coffee, decaffeinated coffee and caffeine intake from coffee with cognitive performance in older adults: National Health and Nutrition Examination Survey (NHANES) 2011-2014. Nutrients. 2020;12(3):840. doi:10.3390/nu12030840 van Gelder BM, Buijsse B, Tijhuis M, et al. Coffee consumption is inversely associated with cognitive decline in elderly European men: the FINE Study. Eur J Clin Nutr. 2007;61(2):226-232. doi:10.1038/sj.ejcn.1602495 Eskelinen MH, Ngandu T, Tuomilehto J, Soininen H, Kivipelto M. Midlife coffee and tea drinking and the risk of late-life dementia: a population-based CAIDE study. J Alzheimers Dis. 2009;16(1):85-91. doi:10.3233/JAD-2009-0920 Barranco Quintana JL, Allam MF, Serrano Del Castillo A, Fernández-Crehuet Navajas R. Alzheimer’s disease and coffee: a quantitative review. Neurol Res. 2007;29(1):91-95. doi:10.1179/174313206X152546 Costa J, Lunet N, Santos C, Santos J, Vaz-Carneiro A. Caffeine exposure and the risk of Parkinson’s disease: a systematic review and meta-analysis of observational studies. J Alzheimers Dis. 2010;20 Suppl 1(s1):S221-S238. doi:10.3233/JAD-2010-091525 Vila-Luna S, Cabrera-Isidoro S, Vila-Luna L, et al. Chronic caffeine consumption prevents cognitive decline from young to middle age in rats, and is associated with increased length, branching, and spine density of basal dendrites in CA1 hippocampal neurons. Neuroscience. 2012;202:384-395. doi:10.1016/j.neuroscience.2011.11.053 Ruggiero M, Calvello R, Porro C, Messina G, Cianciulli A, Panaro MA. Neurodegenerative diseases: Can caffeine be a powerful ally to weaken neuroinflammation? Int J Mol Sci. 2022;23(21):12958. doi:10.3390/ijms232112958 Londzin P, Zamora M, Kąkol B, Taborek A, Folwarczna J. Potential of caffeine in Alzheimer’s disease-A review of experimental studies. Nutrients. 2021;13(2):537. doi:10.3390/nu13020537 Schepici G, Silvestro S, Bramanti P, Mazzon E. Caffeine: An overview of its beneficial effects in experimental models and clinical trials of Parkinson’s disease. Int J Mol Sci. 2020;21(13):4766. doi:10.3390/ijms21134766 Maughan RJ, Griffin J. Caffeine ingestion and fluid balance: a review. J Hum Nutr Diet. 2003;16(6):411-420. doi:10.1046/j.1365-277x.2003.00477.x Killer SC, Blannin AK, Jeukendrup AE. No evidence of dehydration with moderate daily coffee intake: a counterbalanced cross-over study in a free-living population. PLoS One. 2014;9(1):e84154. doi:10.1371/journal.pone.0084154 Yu T, Campbell SC, Stockmann C, et al. Pregnancy-induced changes in the pharmacokinetics of caffeine and its metabolites. J Clin Pharmacol. 2016;56(5):590-596. doi:10.1002/jcph.632 Jafari A, Naghshi S, Shahinfar H, et al. Relationship between maternal caffeine and coffee intake and pregnancy loss: A grading of recommendations assessment, development, and evaluation-assessed, dose-response meta-analysis of observational studies. Front Nutr. 2022;9:886224. doi:10.3389/fnut.2022.886224 Paula T de MDE, Cardoso LC, Felicioni F, et al. Maternal chronic caffeine intake impairs fertility, placental vascularization and fetal development in mice. Reprod Toxicol. 2023;121(108471):108471. doi:10.1016/j.reprotox.2023.108471 Yadegari M, Khazaei M, Anvari M, Eskandari M. Prenatal caffeine exposure impairs pregnancy in rats. Int J Fertil Steril. 2016;9(4):558-562. doi:10.22074/ijfs.2015.4616 Qian J, Chen Q, Ward SM, Duan E, Zhang Y. Impacts of caffeine during pregnancy. Trends Endocrinol Metab. 2020;31(3):218-227. doi:10.1016/j.tem.2019.11.004 See omnystudio.com/listener for privacy information.
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  • Hoeveel eiwit heb je echt nodig? #2
    Eiwitten: iedereen praat erover, waardoor ook Tom door de bomen het bos niet meer ziet. Daarom duiken dokter Alexander Rakic en proefkonijn Tom van der Kolk in deze aflevering van Lang Zal Je Leven in de wereld van eiwitten. Hoeveel heb je écht nodig, wanneer kun je het het best nemen, en helpt meer eiwit eten eigenlijk bij afvallen? Ze factchecken de populairste eiwitclaims: Moet je direct na het sporten eten vanwege het anabolic window? Hoeveel gram eiwit heb je nodig per kilo lichaamsgewicht? Helpt eiwit eten bij vetverlies? En is vegetarisch eten echt minder effectief dan vlees? Tom test het in de praktijk, Alexander checkt de wetenschap. 🗣️ Waar zoek jij naar steun? Als grootste online therapieplatform ter wereld biedt Betterhelp toegang tot deskundige therapeuten. Luisteraars van deze podcast krijgen 10% korting op de eerste maand via www.betterhelp.com/langzaljeleven 🎧 Geproduceerd door Tonny Media👉 Volg ons op Instagram, TikTok en YouTube🥼Alle onderzoeken die in deze aflevering worden besproken vind je hier: Morton RW, Murphy KT, McKellar SR, Schoenfeld BJ, Henselmans M, Helms E, Aragon AA, Devries MC, Banfield L, Krieger JW, Phillips SM. A systematic review, meta-analysis and meta-regression of the effect of protein supplementation on resistance training-induced gains in muscle mass and strength in healthy adults. Br J Sports Med. 2018 Mar;52(6):376-384. doi: 10.1136/bjsports-2017-097608. Epub 2017 Jul 11. Erratum in: Br J Sports Med. 2020 Oct;54(19):e7. doi: 10.1136/bjsports-2017-097608corr1. PMID: 28698222; PMCID: PMC5867436. Nunes EA, Colenso-Semple L, McKellar SR, Yau T, Ali MU, Fitzpatrick-Lewis D, Sherifali D, Gaudichon C, Tomé D, Atherton PJ, Robles MC, Naranjo-Modad S, Braun M, Landi F, Phillips SM. Systematic review and meta-analysis of protein intake to support muscle mass and function in healthy adults. J Cachexia Sarcopenia Muscle. 2022 Apr;13(2):795-810. doi: 10.1002/jcsm.12922. Epub 2022 Feb 20. PMID: 35187864; PMCID: PMC8978023. Tagawa R, Watanabe D, Ito K, Otsuyama T, Nakayama K, Sanbongi C, Miyachi M. Synergistic Effect of Increased Total Protein Intake and Strength Training on Muscle Strength: A Dose-Response Meta-analysis of Randomized Controlled Trials. Sports Med Open. 2022 Sep 4;8(1):110. doi: 10.1186/s40798-022-00508-w. PMID: 36057893; PMCID: PMC9441410. Santini MH, Erwig Leitão A, Mazzolani BC, Smaira FI, de Souza MSC, Santamaria A, Gualano B, Roschel H. Similar effects between animal-based and plant-based protein blend as complementary dietary protein on muscle adaptations to resistance training: findings from a randomized clinical trial. J Int Soc Sports Nutr. 2025 Dec;22(1):2568047. doi: 10.1080/15502783.2025.2568047. Epub 2025 Oct 8. PMID: 41059835; PMCID: PMC12509290. López-Moreno M, Rossi EV, López-Gil JF, Marrero-Fernández P, Roldán-Ruiz A, Bertotti G. Are Plant-Based Diets Detrimental to Muscular Strength? A Systematic Review and Meta-Analysis of Randomized Controlled Trials. Sports Med Open. 2025 Jun 2;11(1):62. doi: 10.1186/s40798-025-00852-7. PMID: 40455307; PMCID: PMC12130401. Tagawa R, Watanabe D, Ito K, Ueda K, Nakayama K, Sanbongi C, Miyachi M. Dose-response relationship between protein intake and muscle mass increase: a systematic review and meta-analysis of randomized controlled trials. Nutr Rev. 2020 Nov 4;79(1):66–75. doi: 10.1093/nutrit/nuaa104. Epub ahead of print. PMID: 33300582; PMCID: PMC7727026. Trommelen J, van Lieshout GAA, Nyakayiru J, Holwerda AM, Smeets JSJ, Hendriks FK, van Kranenburg JMX, Zorenc AH, Senden JM, Goessens JPB, Gijsen AP, van Loon LJC. The anabolic response to protein ingestion during recovery from exercise has no upper limit in magnitude and duration in vivo in humans. Cell Rep Med. 2023 Dec 19;4(12):101324. doi: 10.1016/j.xcrm.2023.101324. PMID: 38118410; PMCID: PMC10772463. Zhao S, Zhang H, Xu Y, Li J, Du S, Ning Z. The effect of protein intake on athletic performance: a systematic review and meta-analysis. Front Nutr. 2024 Nov 6;11:1455728. doi: 10.3389/fnut.2024.1455728. PMID: 39628467; PMCID: PMC11613885. Hudson JL, Iii REB, Campbell WW. Protein Distribution and Muscle-Related Outcomes: Does the Evidence Support the Concept? Nutrients. 2020 May 16;12(5):1441. doi: 10.3390/nu12051441. PMID: 32429355; PMCID: PMC7285146. Møller G, Rikardt Andersen J, Ritz C, P Silvestre M, Navas-Carretero S, Jalo E, Christensen P, Simpson E, Taylor M, Martinez JA, Macdonald I, Swindell N, Mackintosh KA, Stratton G, Fogelholm M, Larsen TM, Poppitt SD, Dragsted LO, Raben A. Higher Protein Intake Is Not Associated with Decreased Kidney Function in Pre-Diabetic Older Adults Following a One-Year Intervention-A Preview Sub-Study. Nutrients. 2018 Jan 9;10(1):54. doi: 10.3390/nu10010054. PMID: 29315212; PMCID: PMC5793282. Cheng Y, Zheng G, Song Z, Zhang G, Rao X, Zeng T. Association between dietary protein intake and risk of chronic kidney disease: a systematic review and meta-analysis. Front Nutr. 2024 Jun 14;11:1408424. doi: 10.3389/fnut.2024.1408424. PMID: 38946781; PMCID: PMC11212527. Davies RW, Lynch AE, Kumar U, Jakeman PM. Characterisation of the Muscle Protein Synthetic Response to Resistance Exercise in Healthy Adults: A Systematic Review and Exploratory Meta-Analysis. Transl Sports Med. 2024 Apr 30;2024:3184356. doi: 10.1155/2024/3184356. PMID: 38716482; PMCID: PMC11074832. Kokura Y, Ueshima J, Saino Y, Maeda K. Enhanced protein intake on maintaining muscle mass, strength, and physical function in adults with overweight/obesity: A systematic review and meta-analysis. Clin Nutr ESPEN. 2024 Oct;63:417-426. doi: 10.1016/j.clnesp.2024.06.030. Epub 2024 Jun 24. PMID: 39002131. Guarneiri LL, Adams CG, Garcia-Jackson B, Koecher K, Wilcox ML, Maki KC. Effects of Varying Protein Amounts and Types on Diet-Induced Thermogenesis: A Systematic Review and Meta-Analysis. Adv Nutr. 2024 Dec;15(12):100332. doi: 10.1016/j.advnut.2024.100332. Epub 2024 Oct 31. PMID: 39486625; PMCID: PMC11625215. See omnystudio.com/listener for privacy information.
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  • Helpt een ijsbad echt? #1
    In deze aflevering van Lang Zal Je Leven onderzoeken dokter Alexander Rakic en proefkonijn Tom van der Kolk wat een ijsbad écht doet met je lichaam en brein. Helpt het bij spierherstel na het sporten, versterkt het je immuunsysteem, verhoogt het je dopamine, en kun je er zelfs van afvallen? Of is het vooral een koude hype die lekker klinkt op TikTok? Tom test het zelf, Alexander checkt de wetenschap. 🗣️ Waar zoek jij naar steun? Als grootste online therapieplatform ter wereld biedt Betterhelp toegang tot deskundige therapeuten. Luisteraars van deze podcast krijgen 10% korting op de eerste maand via www.betterhelp.com/langzaljeleven 🎧 Geproduceerd door Tonny Media👉 Volg ons op Instagram, TikTok en YouTube🥼Alle onderzoeken die Alexander heeft gelezen voor deze aflevering vind je hier: Wang H, Wang L, Pan Y. Impact of different doses of cold water immersion (duration and temperature variations) on recovery from acute exercise-induced muscle damage: a network meta-analysis. Front Physiol. 2025 Feb 26;16:1525726. doi: 10.3389/fphys.2025.1525726. PMID: 40078372; PMCID: PMC11897523.Cain T, Brinsley J, Bennett H, Nelson M, Maher C, Singh B. Effects of cold-water immersion on health and wellbeing: A systematic review and meta-analysis. PLoS One. 2025 Jan 29;20(1):e0317615. doi: 10.1371/journal.pone.0317615. PMID: 39879231; PMCID: PMC11778651.Lee, H. J., Alirzayeva, H., Koyuncu, S., Rueber, A., Noormohammadi, A., & Vilchez, D. (2023). Cold temperature extends longevity and prevents disease-related protein aggregation through PA28γ-induced proteasomes. Nature Aging, 3(5), 546–566. https://doi.org/10.1038/s43587-023-00383-4 Roberts, L. A., Raastad, T., Markworth, J. F., et al. (2015). Post-exercise cold water immersion attenuates acute anabolic signalling and long-term adaptations in muscle to strength training. Journal of Physiology, 593(18), 4285–4301. https://doi.org/10.1113/jp270570 Janský, L., Pospíšilová, D., Honzová, S., et al. (1996). Immune system of cold-exposed and cold-adapted humans. European Journal of Applied Physiology, 72(5–6), 445–450. https://doi.org/10.1007/bf00242274 Wang, Y., Li, S., Zhang, Y., et al. (2021). Heat and cold therapy reduce pain in patients with delayed onset muscle soreness: A systematic review and meta-analysis of 32 randomized controlled trials. Physical Therapy in Sport, 48, 177–187. https://doi.org/10.1016/j.ptsp.2021.01.004 Qu, C., Wu, Z., Xu, M., et al. (2020). Cryotherapy models and timing-sequence recovery of exercise-induced muscle damage in middle- and long-distance runners. Journal of Athletic Training, 55(4), 329–335. https://doi.org/10.4085/1062-6050-529-18 Saari, T. J., Raiko, J., U-Din, M., et al. (2020). Basal and cold-induced fatty acid uptake of human brown adipose tissue is impaired in obesity. Scientific Reports, 10, 1–11. https://doi.org/10.1038/s41598-020-71197-2 Brenner, I. K., Castellani, J. W., Gabaree, C., et al. (1999). Immune changes in humans during cold exposure: Effects of prior heating and exercise. Journal of Applied Physiology, 87(2), 699–710. https://doi.org/10.1152/jappl.1999.87.2.699 Duong, H., & Patel, G. (2024). Hypothermia. StatPearls Publishing. https://www.ncbi.nlm.nih.gov/books/NBK545239/ Doets, J. J. R., Topper, M., & Nugter, A. M. (2021). A systematic review and meta-analysis of the effect of whole body cryotherapy on mental health problems. Complementary Therapies in Medicine, 63, 102783. https://doi.org/10.1016/j.ctim.2021.102783 Espeland, D., de Weerd, L., & Mercer, J. B. (2022). Health effects of voluntary exposure to cold water – a continuing subject of debate. International Journal of Circumpolar Health, 81(1). https://doi.org/10.1080/22423982.2022.2111789 Fuchs, C. J., Kouw, I. W. K., Churchward-Venne, T. A., et al. (2020). Postexercise cooling impairs muscle protein synthesis rates in recreational athletes. Journal of Physiology, 598(4), 755–772. https://doi.org/10.1113/jp278996 Pretorius, T., Bristow, G. K., Steinman, A. M., & Giesbrecht, G. G. (2006). Thermal effects of whole head submersion in cold water on nonshivering humans. Journal of Applied Physiology, 101(2), 669–675. https://doi.org/10.1152/japplphysiol.01241.2005 Keramidas, M. E., & Botonis, P. G. (2021). Short-term sleep deprivation and human thermoregulatory function during thermal challenges. Experimental Physiology, 106(5), 1139–1148. https://doi.org/10.1113/EP089467 Bleakley, C. M., Bieuzen, F., Davison, G. W., & Costello, J. T. (2014). Whole-body cryotherapy: Empirical evidence and theoretical perspectives. Open Access Journal of Sports Medicine, 5, 25–36. https://doi.org/10.2147/OAJSM.S41655 Machado, A. F., Ferreira, P. H., Micheletti, J. K., et al. (2016). Can water temperature and immersion time influence the effect of cold water immersion on muscle soreness? A systematic review and meta-analysis. Sports Medicine, 46(4), 503–514. https://doi.org/10.1007/s40279-015-0431-7 Wilson, L. J., Cockburn, E., Paice, K., et al. (2018). Recovery following a marathon: A comparison of cold water immersion, whole body cryotherapy and a placebo control. European Journal of Applied Physiology, 118(1), 153–163. https://doi.org/10.1007/s00421-017-3757-z Degroot, D. W., & Kenney, W. L. (2007). Impaired defense of core temperature in aged humans during mild cold stress. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 292(1), R103–R108. https://doi.org/10.1152/ajpregu.00074.2006 Blondin, D. P., Labbé, S. M., Tingelstad, H. C., et al. (2014). Increased brown adipose tissue oxidative capacity in cold-acclimated humans. Journal of Clinical Endocrinology & Metabolism, 99(3), E438–E446. https://doi.org/10.1210/jc.2013-3901 Hanssen, M. J. W., Hoeks, J., Brans, B., et al. (2015). Short-term cold acclimation improves insulin sensitivity in patients with type 2 diabetes mellitus. Nature Medicine, 21(8), 863–865. https://doi.org/10.1038/nm.3891 Johnson, J. M., Minson, C. T., & Kellogg, D. L., Jr. (2014). Cutaneous vasodilator and vasoconstrictor mechanisms in temperature regulation. Comprehensive Physiology, 4(1), 33–89. https://doi.org/10.1002/cphy.c130015 Westpac Marine. (2024). Hypothermia chart. Retrieved September 14, 2024, from https://westpacmarine.com/samples/hypothermia_chart.php Adnan, H., William, J. R., & Anthony, W. B. (2018). Enhancing the physiology and effectiveness of whole-body cryotherapy treatment for sports recovery by establishing an optimum protocol: A review of recent perspectives. Journal of Physical Medicine, 1(1). https://doi.org/10.36959/942/338 Gibas-Dorna, M., Checinska, Z., Korek, E., et al. (2016). Variations in leptin and insulin levels within one swimming season in non-obese female cold water swimmers. Scandinavian Journal of Clinical and Laboratory Investigation, 76(6), 486–491. https://doi.org/10.1080/00365513.2016.1201851 Blondin, D. P., Tingelstad, H. C., Mantha, O. L., Gosselin, C., & Haman, F. (2014). Maintaining thermogenesis in cold exposed humans: Relying on multiple metabolic pathways. Comprehensive Physiology, 4(4), 1383–1402. https://doi.org/10.1002/cphy.c130043 Eglin, C. M., & Tipton, M. J. (2005). Repeated cold showers as a method of habituating humans to the initial responses to cold water immersion. European Journal of Applied Physiology, 93(5–6), 624–629. https://doi.org/10.1007/s00421-004-1239-6 Srámek, P., Simecková, M., Janský, L., Savlíková, J., & Vybíral, S. (2000). Human physiological responses to immersion into water of different temperatures. European Journal of Applied Physiology, 81(5), 436–442. https://doi.org/10.1007/s004210050065 Pawłowska, M., Mila-Kierzenkowska, C., Boraczyński, T., et al. (2021). The effect of submaximal exercise followed by short-term cold-water immersion on the inflammatory state in healthy recreational athletes: A cross-over study. Journal of Clinical Medicine, 10(18), 4239. https://doi.org/10.3390/jcm10184239 Rymaszewska, J., Lion, K. M., Pawlik-Sobecka, L., et al. (2020). Efficacy of the whole-body cryotherapy as add-on therapy to pharmacological treatment of depression: A randomized controlled trial. Frontiers in Psychiatry, 11. https://doi.org/10.3389/fpsyt.2020.00522 Kunutsor, S. K., Lehoczki, A., & Laukkanen, J. A. (2024). The untapped potential of cold water therapy as part of a lifestyle intervention for promoting healthy aging. GeroScience. https://doi.org/10.1007/s11357-024-01295-w Fink, W. J., Costill, D. L., & Van Handel, P. J. (1975). Leg muscle metabolism during exercise in the heat and cold. European Journal of Applied Physiology and Occupational Physiology, 34(3), 183–190. https://doi.org/10.1007/BF00999931 Bergh, U., & Ekblom, B. (1979). 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C., & Fyfe, J. J. (2021). Post-exercise cold water immersion effects on physiological adaptations to resistance training and the underlying mechanisms in skeletal muscle: A narrative review. Frontiers in Sports and Active Living, 3, 660291. https://doi.org/10.3389/fspor.2021.660291 Ikäheimo, T. M. (2018). Cardiovascular diseases, cold exposure and exercise. Temperature (Austin), 5(2), 123–146. https://doi.org/10.1080/23328940.2017.1414014 Swift, R. W. (1932). The effects of low environmental temperature upon metabolism. Journal of Nutrition, 5(3), 227–249. https://doi.org/10.1093/jn/5.3.227 Paulsen, G., Mikkelsen, U. R., Raastad, T., & Peake, J. M. (2012). Leucocytes, cytokines and satellite cells: What role do they play in muscle damage and regeneration following eccentric exercise? Exercise Immunology Review, 18, 42–97. https://www.ncbi.nlm.nih.gov/pubmed/22876722 Zhang, B., Xiao, R., Ronan, E. A., et al. (2015). Environmental temperature differentially modulates C. elegans longevity through a thermosensitive TRP channel. Cell Reports, 11(9), 1414–1424. https://doi.org/10.1016/j.celrep.2015.04.066 Hankenson, F. C., Marx, J. O., Gordon, C. J., & David, J. M. (2018). Effects of rodent thermoregulation on animal models in the research environment. Comparative Medicine, 68(6), 425–438. https://doi.org/10.30802/aalas-cm-18-000049 Moore, E., Fuller, J. T., Buckley, J. D., et al. (2022). Impact of cold-water immersion compared with passive recovery following a single bout of strenuous exercise on athletic performance in physically active participants: A systematic review with meta-analysis and meta-regression. Sports Medicine, 52(7), 1667–1688. https://doi.org/10.1007/s40279-022-01644-9 Espeland, D., de Weerd, L., & Mercer, J. B. (2022). Health effects of voluntary exposure to cold water – a continuing subject of debate. International Journal of Circumpolar Health, 81(1). https://doi.org/10.1080/22423982.2022.2111789 See omnystudio.com/listener for privacy information.
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  • Trailer
    Klei drinken reinigt je lichaam, intermittent fasting helpt met afvallen en koffieklysma's zijn goed voor je darmen. Het wemelt tegenwoordig van de trends en hypes, die je zouden helpen om gezonder oud te worden. Maar hoe weet je wat klopt? Je kunt er eindeloos over lezen of alles zelf testen. Of je besteedt het allebei uit door deze podcast te luisteren. In Lang Zal Je Leven voorziet dokter Alexander je van de theorie over gezondheidsclaims. Praktijkexpert Tom ondervindt alles aan den lijve. Allemaal zodat jij kan vieren dat je alle kennis op een presenteerblaadje krijgt. Lang Zal Je Leven!See omnystudio.com/listener for privacy information.
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    0:45

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Klei drinken reinigt je lichaam, intermittent fasting helpt met afvallen en koffieklysma's zijn goed voor je darmen. Het wemelt tegenwoordig van de trends en hypes, die je zouden helpen om gezonder oud te worden. Maar hoe weet je wat klopt? Je kunt er eindeloos over lezen of alles zelf testen. Of je besteedt het allebei uit door deze podcast te luisteren. In Lang Zal Je Leven voorziet dokter Alexander je van de theorie over gezondheidsclaims. Praktijkexpert Tom ondervindt alles aan den lijve. Allemaal zodat jij kan vieren dat je alle kennis op een presenteerblaadje krijgt. Lang Zal Je Leven!
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